Landscape of HER2-low breast cancer: Insights from a six-year study on prevalence and clinicopathological characteristics

Human epidermal growth factor receptor 2 (HER2)-low breast cancer has emerged as a subtype of breast cancer, defined by HER2 1+/2+ in immunohistochemistry (IHC) and absence of ERBB2 gene amplification on fluorescence in situ hybridization (FISH). Recent trials showed marked response of HER2-low brea...

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Veröffentlicht in:	Annals of diagnostic pathology 2024-10, Vol.72, p.152326, Article 152326
Hauptverfasser:	Khalil, Michel Abou, Habibian, Lea, Martin, Christine, Semaan, Karl, Khaddage, Abir, El Kassis, Nadine, Kesserouani, Carole, Kourie, Hampig Raphael, Atallah, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Clinicopathologic features Female France - epidemiology Gene Amplification HER2-low HER2-zero Humans Immunohistochemistry - methods In Situ Hybridization, Fluorescence - methods Middle Aged Prevalence Receptor, ErbB-2 - genetics Receptor, ErbB-2 - metabolism Receptors, Estrogen - metabolism Receptors, Progesterone - metabolism Retrospective Studies Trastuzumab-deruxtecan
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