Effect of Ambient Conditions on Acoustic Activation of the Perfluoropropane Droplets Within the Infarct Zone
Acoustically activated perfluoropropane droplets (PD) formulated from lipid encapsulated microbubble preparations produce a delayed myocardial contrast enhancement that preferentially highlights the infarct zones (IZ). Since activation of PDs may be temperature sensitive, it is unclear what effect b...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2024-08, Vol.50 (8), p.1232-1239 |
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| creator | Li, Shouqiang Chen, Cheng Lof, John Stolze, Elizabeth A. Sklenar, Jiri Chen, Xucai Pacella, John J. Villanueva, Flordeliza S. Matsunaga, Terry O. Everbach, E. Carr Radio, Stanley J. Westphal, Sherry Xie, Feng Leng, Xiaoping Porter, Thomas R. |
| description | Acoustically activated perfluoropropane droplets (PD) formulated from lipid encapsulated microbubble preparations produce a delayed myocardial contrast enhancement that preferentially highlights the infarct zones (IZ). Since activation of PDs may be temperature sensitive, it is unclear what effect body temperature (BT) has on acoustic activation (AA).
We sought to determine whether the microvascular retention and degree of myocardial contrast intensity (MCI) would be affected by BT at the time of intravenous injection.
We administered intravenous (IV) PD in nine rats following 60 min of ischemia followed by reperfusion. Injections in these rats were given at temperatures above and below 36.5°C, with high MI activation in both groups at 3 or 6 min following IV injection (IVI). In six additional rats (three in each group), IV PDs were given only at one temperature ( |
| doi_str_mv | 10.1016/j.ultrasmedbio.2024.04.011 |
| format | Article |
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We sought to determine whether the microvascular retention and degree of myocardial contrast intensity (MCI) would be affected by BT at the time of intravenous injection.
We administered intravenous (IV) PD in nine rats following 60 min of ischemia followed by reperfusion. Injections in these rats were given at temperatures above and below 36.5°C, with high MI activation in both groups at 3 or 6 min following IV injection (IVI). In six additional rats (three in each group), IV PDs were given only at one temperature (<36.5°C or ≥36.5°C), permitting a total of 12 comparisons of different BT. Differences in background subtracted MCI at 3-6 min post-injection were compared in the infarct zone (IZ) and remote zone (RZ). Post-mortem lung hematoxylin and eosin (H&E) staining was performed to assess the effect potential thermal activation on lung tissue.
Selective MCI within the IZ was observed in 8 of 12 rats who received IVI of PDs at <36.5°C, but none of the 12 rats who had IVI at the higher temperature (p < 0.0001). Absolute MCI following droplet activation was significantly higher in both the IZ and RZ when given at the lower BT. H&E indicated significant red blood extravasation in 5/7 rats who had had IV injections at higher BT, and 0/7 rats who had IV PDs at <36.5°C.
Selective IZ enhancement with AA of intravenous PDs is possible, but temperature sensitive. Thermal activation appears to occur when PDs are given at higher temperatures, preventing AA, and increasing unwanted bioeffects.]]></description><identifier>ISSN: 0301-5629</identifier><identifier>ISSN: 1879-291X</identifier><identifier>EISSN: 1879-291X</identifier><identifier>DOI: 10.1016/j.ultrasmedbio.2024.04.011</identifier><identifier>PMID: 38760280</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Acoustic activation ; Acoustics ; Animals ; Body Temperature ; Contrast Media ; Droplets ; Fluorocarbons ; Imaging ; Male ; Microbubbles ; Myocardial Infarction - physiopathology ; Perfluoropropane ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Ultrasound in medicine & biology, 2024-08, Vol.50 (8), p.1232-1239</ispartof><rights>2024 World Federation for Ultrasound in Medicine & Biology</rights><rights>Copyright © 2024 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c238t-d3e9cb5df0135a8ba50f911c1e0092803876db5eae2a1519bb3c46d0cea771f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ultrasmedbio.2024.04.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38760280$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Shouqiang</creatorcontrib><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Lof, John</creatorcontrib><creatorcontrib>Stolze, Elizabeth A.</creatorcontrib><creatorcontrib>Sklenar, Jiri</creatorcontrib><creatorcontrib>Chen, Xucai</creatorcontrib><creatorcontrib>Pacella, John J.</creatorcontrib><creatorcontrib>Villanueva, Flordeliza S.</creatorcontrib><creatorcontrib>Matsunaga, Terry O.</creatorcontrib><creatorcontrib>Everbach, E. Carr</creatorcontrib><creatorcontrib>Radio, Stanley J.</creatorcontrib><creatorcontrib>Westphal, Sherry</creatorcontrib><creatorcontrib>Xie, Feng</creatorcontrib><creatorcontrib>Leng, Xiaoping</creatorcontrib><creatorcontrib>Porter, Thomas R.</creatorcontrib><title>Effect of Ambient Conditions on Acoustic Activation of the Perfluoropropane Droplets Within the Infarct Zone</title><title>Ultrasound in medicine & biology</title><addtitle>Ultrasound Med Biol</addtitle><description><![CDATA[Acoustically activated perfluoropropane droplets (PD) formulated from lipid encapsulated microbubble preparations produce a delayed myocardial contrast enhancement that preferentially highlights the infarct zones (IZ). Since activation of PDs may be temperature sensitive, it is unclear what effect body temperature (BT) has on acoustic activation (AA).
We sought to determine whether the microvascular retention and degree of myocardial contrast intensity (MCI) would be affected by BT at the time of intravenous injection.
We administered intravenous (IV) PD in nine rats following 60 min of ischemia followed by reperfusion. Injections in these rats were given at temperatures above and below 36.5°C, with high MI activation in both groups at 3 or 6 min following IV injection (IVI). In six additional rats (three in each group), IV PDs were given only at one temperature (<36.5°C or ≥36.5°C), permitting a total of 12 comparisons of different BT. Differences in background subtracted MCI at 3-6 min post-injection were compared in the infarct zone (IZ) and remote zone (RZ). Post-mortem lung hematoxylin and eosin (H&E) staining was performed to assess the effect potential thermal activation on lung tissue.
Selective MCI within the IZ was observed in 8 of 12 rats who received IVI of PDs at <36.5°C, but none of the 12 rats who had IVI at the higher temperature (p < 0.0001). Absolute MCI following droplet activation was significantly higher in both the IZ and RZ when given at the lower BT. H&E indicated significant red blood extravasation in 5/7 rats who had had IV injections at higher BT, and 0/7 rats who had IV PDs at <36.5°C.
Selective IZ enhancement with AA of intravenous PDs is possible, but temperature sensitive. Thermal activation appears to occur when PDs are given at higher temperatures, preventing AA, and increasing unwanted bioeffects.]]></description><subject>Acoustic activation</subject><subject>Acoustics</subject><subject>Animals</subject><subject>Body Temperature</subject><subject>Contrast Media</subject><subject>Droplets</subject><subject>Fluorocarbons</subject><subject>Imaging</subject><subject>Male</subject><subject>Microbubbles</subject><subject>Myocardial Infarction - physiopathology</subject><subject>Perfluoropropane</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0301-5629</issn><issn>1879-291X</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE9r3DAQxUVIabZpv0IwOeXi7YwU_8tt2aRtINAeWlp6EbI8Ilq8ViLJgX77jrtJ6bEwMEJ6o_fmJ8Q5whoB6_e79TzmaNKeht6HtQR5uQYuxCOxwrbpStnhj2OxAgVYVrXsTsSblHYA0NSqeS1OVNvUIFtYifHGObK5CK7Y7HtPUy62YRp89mFKRZiKjQ1zyt7yIfsns9wv4nxPxReKbpxDDA9cZqLimvtIORXffb730x_R7eRMZIOfYaK34pUzY6J3z_1UfPtw83X7qbz7_PF2u7krrVRtLgdFne2rwQGqyrS9qcB1iBYJoOPUS_qhr8iQNFhh1_fKXtYDWDJNgw7Uqbg4_MvBHmdKWe99sjSOHJK30Qqqum5AomTp1UFqY0gpktMP0e9N_KUR9EJb7_S_tPVCWwMXIg-fPfvMPT__HX3By4Lrg4B42ydPUSfLjC0NPjJ1PQT_Pz6_AX5imXI</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Li, Shouqiang</creator><creator>Chen, Cheng</creator><creator>Lof, John</creator><creator>Stolze, Elizabeth A.</creator><creator>Sklenar, Jiri</creator><creator>Chen, Xucai</creator><creator>Pacella, John J.</creator><creator>Villanueva, Flordeliza S.</creator><creator>Matsunaga, Terry O.</creator><creator>Everbach, E. Carr</creator><creator>Radio, Stanley J.</creator><creator>Westphal, Sherry</creator><creator>Xie, Feng</creator><creator>Leng, Xiaoping</creator><creator>Porter, Thomas R.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202408</creationdate><title>Effect of Ambient Conditions on Acoustic Activation of the Perfluoropropane Droplets Within the Infarct Zone</title><author>Li, Shouqiang ; Chen, Cheng ; Lof, John ; Stolze, Elizabeth A. ; Sklenar, Jiri ; Chen, Xucai ; Pacella, John J. ; Villanueva, Flordeliza S. ; Matsunaga, Terry O. ; Everbach, E. Carr ; Radio, Stanley J. ; Westphal, Sherry ; Xie, Feng ; Leng, Xiaoping ; Porter, Thomas R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c238t-d3e9cb5df0135a8ba50f911c1e0092803876db5eae2a1519bb3c46d0cea771f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acoustic activation</topic><topic>Acoustics</topic><topic>Animals</topic><topic>Body Temperature</topic><topic>Contrast Media</topic><topic>Droplets</topic><topic>Fluorocarbons</topic><topic>Imaging</topic><topic>Male</topic><topic>Microbubbles</topic><topic>Myocardial Infarction - physiopathology</topic><topic>Perfluoropropane</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Shouqiang</creatorcontrib><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Lof, John</creatorcontrib><creatorcontrib>Stolze, Elizabeth A.</creatorcontrib><creatorcontrib>Sklenar, Jiri</creatorcontrib><creatorcontrib>Chen, Xucai</creatorcontrib><creatorcontrib>Pacella, John J.</creatorcontrib><creatorcontrib>Villanueva, Flordeliza S.</creatorcontrib><creatorcontrib>Matsunaga, Terry O.</creatorcontrib><creatorcontrib>Everbach, E. Carr</creatorcontrib><creatorcontrib>Radio, Stanley J.</creatorcontrib><creatorcontrib>Westphal, Sherry</creatorcontrib><creatorcontrib>Xie, Feng</creatorcontrib><creatorcontrib>Leng, Xiaoping</creatorcontrib><creatorcontrib>Porter, Thomas R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Shouqiang</au><au>Chen, Cheng</au><au>Lof, John</au><au>Stolze, Elizabeth A.</au><au>Sklenar, Jiri</au><au>Chen, Xucai</au><au>Pacella, John J.</au><au>Villanueva, Flordeliza S.</au><au>Matsunaga, Terry O.</au><au>Everbach, E. Carr</au><au>Radio, Stanley J.</au><au>Westphal, Sherry</au><au>Xie, Feng</au><au>Leng, Xiaoping</au><au>Porter, Thomas R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Ambient Conditions on Acoustic Activation of the Perfluoropropane Droplets Within the Infarct Zone</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2024-08</date><risdate>2024</risdate><volume>50</volume><issue>8</issue><spage>1232</spage><epage>1239</epage><pages>1232-1239</pages><issn>0301-5629</issn><issn>1879-291X</issn><eissn>1879-291X</eissn><abstract><![CDATA[Acoustically activated perfluoropropane droplets (PD) formulated from lipid encapsulated microbubble preparations produce a delayed myocardial contrast enhancement that preferentially highlights the infarct zones (IZ). Since activation of PDs may be temperature sensitive, it is unclear what effect body temperature (BT) has on acoustic activation (AA).
We sought to determine whether the microvascular retention and degree of myocardial contrast intensity (MCI) would be affected by BT at the time of intravenous injection.
We administered intravenous (IV) PD in nine rats following 60 min of ischemia followed by reperfusion. Injections in these rats were given at temperatures above and below 36.5°C, with high MI activation in both groups at 3 or 6 min following IV injection (IVI). In six additional rats (three in each group), IV PDs were given only at one temperature (<36.5°C or ≥36.5°C), permitting a total of 12 comparisons of different BT. Differences in background subtracted MCI at 3-6 min post-injection were compared in the infarct zone (IZ) and remote zone (RZ). Post-mortem lung hematoxylin and eosin (H&E) staining was performed to assess the effect potential thermal activation on lung tissue.
Selective MCI within the IZ was observed in 8 of 12 rats who received IVI of PDs at <36.5°C, but none of the 12 rats who had IVI at the higher temperature (p < 0.0001). Absolute MCI following droplet activation was significantly higher in both the IZ and RZ when given at the lower BT. H&E indicated significant red blood extravasation in 5/7 rats who had had IV injections at higher BT, and 0/7 rats who had IV PDs at <36.5°C.
Selective IZ enhancement with AA of intravenous PDs is possible, but temperature sensitive. Thermal activation appears to occur when PDs are given at higher temperatures, preventing AA, and increasing unwanted bioeffects.]]></abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>38760280</pmid><doi>10.1016/j.ultrasmedbio.2024.04.011</doi><tpages>8</tpages></addata></record> |
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| subjects | Acoustic activation Acoustics Animals Body Temperature Contrast Media Droplets Fluorocarbons Imaging Male Microbubbles Myocardial Infarction - physiopathology Perfluoropropane Rats Rats, Sprague-Dawley |
| title | Effect of Ambient Conditions on Acoustic Activation of the Perfluoropropane Droplets Within the Infarct Zone |
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