Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids

The human blood-brain barrier (hBBB) is a highly specialized structure that regulates passage across blood and central nervous system (CNS) compartments. Despite its critical physiological role, there are no reliable in vitro models that can mimic hBBB development and function. Here, we constructed...

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Veröffentlicht in:	Cell stem cell 2024-06, Vol.31 (6), p.818-833.e11
Hauptverfasser:	Dao, Lan, You, Zhen, Lu, Lu, Xu, Tianyang, Sarkar, Avijite Kumer, Zhu, Hui, Liu, Miao, Calandrelli, Riccardo, Yoshida, George, Lin, Pei, Miao, Yifei, Mierke, Sarah, Kalva, Srijan, Zhu, Haining, Gu, Mingxia, Vadivelu, Sudhakar, Zhong, Sheng, Huang, L. Frank, Guo, Ziyuan
Format:	Artikel
Sprache:	eng
Schlagworte:	assembloids Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology cerebral cavernous malformations Hemangioma, Cavernous, Central Nervous System - metabolism Hemangioma, Cavernous, Central Nervous System - pathology human blood-brain barrier human PSC-derived organoids Humans Models, Biological neuro-vascular development neuro-vascular interactions Organoids - metabolism Organoids - pathology Pluripotent Stem Cells - metabolism single-cell transcriptomics spatial transcriptomics
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