The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience
Previous research has demonstrated the impact of postoperative phosphate levels on liver regeneration and outcomes after liver resection surgeries, a potential predictor for regenerative success and liver failure. However, little is known about the association between low preoperative serum phosphat...
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| Veröffentlicht in: | The Journal of surgical research 2024-07, Vol.299, p.145-150 |
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| container_title | The Journal of surgical research |
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| creator | Davis, Erik S. Seda, Peyton Kolodziej, David Turaczyk Villa, Aneli T. Feng, Lawrence DiGioia, Olivia Nayyar, Apoorve Jehan, Faisal S. Aziz, Hassan |
| description | Previous research has demonstrated the impact of postoperative phosphate levels on liver regeneration and outcomes after liver resection surgeries, a potential predictor for regenerative success and liver failure. However, little is known about the association between low preoperative serum phosphate levels and outcomes in liver resections.
We performed a retrospective analysis of liver resections performed at our institution. Patients were categorized based on preoperative phosphate levels (low versus normal). Our primary outcome measure was posthepatectomy liver failure.
A total of 265 cases met the study criteria. 71 patients (26.7%) had low preoperative phosphate levels. The incidence of posthepatectomy liver failure was higher in the low preoperative phosphate group (19.2% versus 12.4%). However, after propensity score matching, rates of posthepatectomy liver failure were similar between low and normal preoperative phosphate cohorts (13% versus 14%, P = 0.83).
Low preoperative phosphate levels were not associated with worse postoperative outcomes in this study. Further studies are warranted to investigate this association and its relevance as a clinical prognostic factor for postoperative liver failure. |
| doi_str_mv | 10.1016/j.jss.2024.04.027 |
| format | Article |
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We performed a retrospective analysis of liver resections performed at our institution. Patients were categorized based on preoperative phosphate levels (low versus normal). Our primary outcome measure was posthepatectomy liver failure.
A total of 265 cases met the study criteria. 71 patients (26.7%) had low preoperative phosphate levels. The incidence of posthepatectomy liver failure was higher in the low preoperative phosphate group (19.2% versus 12.4%). However, after propensity score matching, rates of posthepatectomy liver failure were similar between low and normal preoperative phosphate cohorts (13% versus 14%, P = 0.83).
Low preoperative phosphate levels were not associated with worse postoperative outcomes in this study. Further studies are warranted to investigate this association and its relevance as a clinical prognostic factor for postoperative liver failure.</description><identifier>ISSN: 0022-4804</identifier><identifier>ISSN: 1095-8673</identifier><identifier>EISSN: 1095-8673</identifier><identifier>DOI: 10.1016/j.jss.2024.04.027</identifier><identifier>PMID: 38759329</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Female ; Hepatectomy - adverse effects ; Humans ; Liver Failure - blood ; Liver Failure - etiology ; Liver regeneration ; Liver resection ; Male ; Middle Aged ; Phosphates - blood ; Posthepatectomy liver failure ; Postoperative Complications - blood ; Postoperative Complications - epidemiology ; Postoperative Complications - etiology ; Preoperative hypophosphatemia ; Preoperative Period ; Propensity Score ; Retrospective Studies ; Surgical outcomes ; Treatment Outcome</subject><ispartof>The Journal of surgical research, 2024-07, Vol.299, p.145-150</ispartof><rights>2024 Elsevier Inc.</rights><rights>Copyright © 2024 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c305t-27905440708a32ad9b0b3de1b080dacf41a9354094a12cf3caa03d6b952efb9c3</cites><orcidid>0000-0003-0406-1946</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jss.2024.04.027$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38759329$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Davis, Erik S.</creatorcontrib><creatorcontrib>Seda, Peyton</creatorcontrib><creatorcontrib>Kolodziej, David Turaczyk</creatorcontrib><creatorcontrib>Villa, Aneli T.</creatorcontrib><creatorcontrib>Feng, Lawrence</creatorcontrib><creatorcontrib>DiGioia, Olivia</creatorcontrib><creatorcontrib>Nayyar, Apoorve</creatorcontrib><creatorcontrib>Jehan, Faisal S.</creatorcontrib><creatorcontrib>Aziz, Hassan</creatorcontrib><title>The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience</title><title>The Journal of surgical research</title><addtitle>J Surg Res</addtitle><description>Previous research has demonstrated the impact of postoperative phosphate levels on liver regeneration and outcomes after liver resection surgeries, a potential predictor for regenerative success and liver failure. However, little is known about the association between low preoperative serum phosphate levels and outcomes in liver resections.
We performed a retrospective analysis of liver resections performed at our institution. Patients were categorized based on preoperative phosphate levels (low versus normal). Our primary outcome measure was posthepatectomy liver failure.
A total of 265 cases met the study criteria. 71 patients (26.7%) had low preoperative phosphate levels. The incidence of posthepatectomy liver failure was higher in the low preoperative phosphate group (19.2% versus 12.4%). However, after propensity score matching, rates of posthepatectomy liver failure were similar between low and normal preoperative phosphate cohorts (13% versus 14%, P = 0.83).
Low preoperative phosphate levels were not associated with worse postoperative outcomes in this study. Further studies are warranted to investigate this association and its relevance as a clinical prognostic factor for postoperative liver failure.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Hepatectomy - adverse effects</subject><subject>Humans</subject><subject>Liver Failure - blood</subject><subject>Liver Failure - etiology</subject><subject>Liver regeneration</subject><subject>Liver resection</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Phosphates - blood</subject><subject>Posthepatectomy liver failure</subject><subject>Postoperative Complications - blood</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - etiology</subject><subject>Preoperative hypophosphatemia</subject><subject>Preoperative Period</subject><subject>Propensity Score</subject><subject>Retrospective Studies</subject><subject>Surgical outcomes</subject><subject>Treatment Outcome</subject><issn>0022-4804</issn><issn>1095-8673</issn><issn>1095-8673</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM9OGzEQh62qqATaB-il8rGXTcf2_rN6ChEUpEhEAs6W1ztLHG3WwfYGuPEOvGGfBNNQjkgjjUbzzW-kj5DvDKYMWPlrPV2HMOXA8ymk4tUnMmEgi6wuK_GZTAA4z_Ia8kNyFMIa0iwr8YUciroqpOByQsbrFdJZCM5YHa0b6AnGe8SBLtw9XXp0W_RpsUO6XLmwXemIdIE77APVQ0uXLsQ-bT29Gv0t-kd6OUbjNhj-Pj3P6JUdbnukcxxiQk4fUpjFweBXctDpPuC3t35Mbs5Or-fn2eLyz8V8tsiMgCJmvJJQ5DlUUGvBdSsbaESLrIEaWm26nGkpihxkrhk3nTBag2jLRhYcu0YacUx-7nO33t2NGKLa2GCw7_WAbgwqfSnLsk4CE8r2qPEuBI-d2nq70f5RMVCvttVaJdvq1baCVLxKNz_e4sdmg-37xX-9Cfi9B5Iv3Fn0Kph_Alrr0UTVOvtB_As8jZJq</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Davis, Erik S.</creator><creator>Seda, Peyton</creator><creator>Kolodziej, David Turaczyk</creator><creator>Villa, Aneli T.</creator><creator>Feng, Lawrence</creator><creator>DiGioia, Olivia</creator><creator>Nayyar, Apoorve</creator><creator>Jehan, Faisal S.</creator><creator>Aziz, Hassan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0406-1946</orcidid></search><sort><creationdate>202407</creationdate><title>The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience</title><author>Davis, Erik S. ; Seda, Peyton ; Kolodziej, David Turaczyk ; Villa, Aneli T. ; Feng, Lawrence ; DiGioia, Olivia ; Nayyar, Apoorve ; Jehan, Faisal S. ; Aziz, Hassan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-27905440708a32ad9b0b3de1b080dacf41a9354094a12cf3caa03d6b952efb9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Hepatectomy - adverse effects</topic><topic>Humans</topic><topic>Liver Failure - blood</topic><topic>Liver Failure - etiology</topic><topic>Liver regeneration</topic><topic>Liver resection</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Phosphates - blood</topic><topic>Posthepatectomy liver failure</topic><topic>Postoperative Complications - blood</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - etiology</topic><topic>Preoperative hypophosphatemia</topic><topic>Preoperative Period</topic><topic>Propensity Score</topic><topic>Retrospective Studies</topic><topic>Surgical outcomes</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davis, Erik S.</creatorcontrib><creatorcontrib>Seda, Peyton</creatorcontrib><creatorcontrib>Kolodziej, David Turaczyk</creatorcontrib><creatorcontrib>Villa, Aneli T.</creatorcontrib><creatorcontrib>Feng, Lawrence</creatorcontrib><creatorcontrib>DiGioia, Olivia</creatorcontrib><creatorcontrib>Nayyar, Apoorve</creatorcontrib><creatorcontrib>Jehan, Faisal S.</creatorcontrib><creatorcontrib>Aziz, Hassan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of surgical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davis, Erik S.</au><au>Seda, Peyton</au><au>Kolodziej, David Turaczyk</au><au>Villa, Aneli T.</au><au>Feng, Lawrence</au><au>DiGioia, Olivia</au><au>Nayyar, Apoorve</au><au>Jehan, Faisal S.</au><au>Aziz, Hassan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience</atitle><jtitle>The Journal of surgical research</jtitle><addtitle>J Surg Res</addtitle><date>2024-07</date><risdate>2024</risdate><volume>299</volume><spage>145</spage><epage>150</epage><pages>145-150</pages><issn>0022-4804</issn><issn>1095-8673</issn><eissn>1095-8673</eissn><abstract>Previous research has demonstrated the impact of postoperative phosphate levels on liver regeneration and outcomes after liver resection surgeries, a potential predictor for regenerative success and liver failure. However, little is known about the association between low preoperative serum phosphate levels and outcomes in liver resections.
We performed a retrospective analysis of liver resections performed at our institution. Patients were categorized based on preoperative phosphate levels (low versus normal). Our primary outcome measure was posthepatectomy liver failure.
A total of 265 cases met the study criteria. 71 patients (26.7%) had low preoperative phosphate levels. The incidence of posthepatectomy liver failure was higher in the low preoperative phosphate group (19.2% versus 12.4%). However, after propensity score matching, rates of posthepatectomy liver failure were similar between low and normal preoperative phosphate cohorts (13% versus 14%, P = 0.83).
Low preoperative phosphate levels were not associated with worse postoperative outcomes in this study. Further studies are warranted to investigate this association and its relevance as a clinical prognostic factor for postoperative liver failure.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38759329</pmid><doi>10.1016/j.jss.2024.04.027</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0003-0406-1946</orcidid></addata></record> |
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| subjects | Adult Aged Female Hepatectomy - adverse effects Humans Liver Failure - blood Liver Failure - etiology Liver regeneration Liver resection Male Middle Aged Phosphates - blood Posthepatectomy liver failure Postoperative Complications - blood Postoperative Complications - epidemiology Postoperative Complications - etiology Preoperative hypophosphatemia Preoperative Period Propensity Score Retrospective Studies Surgical outcomes Treatment Outcome |
| title | The Association Between Low Preoperative Phosphate Levels and Postliver Surgery Outcomes–A Single Center Experience |
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