Induction of indoleamine 2,3-dioxygenase 1 expression in neurons of the central nervous system through inhibition of histone deacetylases blocks the progression of experimental autoimmune encephalomyelitis

•Injection with SB939, an HDAC inhibitor, restricts EAE progression.•The therapeutic effect depended upon IDO1 expression in the neurons of the central nervous system.•IDO1 tryptophan metabolites produced by neuronal cells may act on AHR in pathogenic CD4+ T cells in the CNS in a paracrine fashion....

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Veröffentlicht in:	International immunopharmacology 2024-06, Vol.134, p.112246, Article 112246
Hauptverfasser:	Kim, Chae Eun, Lee, Soung-Min, Yoon, Eun Hye, Won, Hae Jeong, Jung, Yu Jin, Jegal, Yangjin, Kim, Dong Hyun, Kwon, Byungsuk, Seo, Su-Kil
Format:	Artikel
Sprache:	eng
Schlagworte:	AHR HDAC inhibitor IDO1 Neuroinflammation STAT3 acetylation
Online-Zugang:	Volltext
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