Failure of second challenge with mogamulizumab in C-C chemokine receptor 4-positive cutaneous T-cell lymphoma
We report three patients with Sézary syndrome who had previously been successfully treated with mogamulizumab and then failed a second course of the same treatment, despite positive CCR4 expression at the second initiation of mogamulizumab. This suggests that secondary resistance of blood disease to...
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| Veröffentlicht in: | British journal of dermatology (1951) 2024-05, Vol.190 (6), p.920-921 |
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| container_title | British journal of dermatology (1951) |
| container_volume | 190 |
| creator | Stammler, Romain Ta, Van Anh Cohen, Elisabeth Ram-Wolff, Caroline Bozonnat, Alizée Battesti, Gilles Louveau, Baptiste Mourah, Samia Battistella, Maxime Moins-Teisserenc, Hélène de Masson, Adèle |
| description | We report three patients with Sézary syndrome who had previously been successfully treated with mogamulizumab and then failed a second course of the same treatment, despite positive CCR4 expression at the second initiation of mogamulizumab. This suggests that secondary resistance of blood disease to mogamulizumab may be independent of target expression. |
| doi_str_mv | 10.1093/bjd/ljae085 |
| format | Article |
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Ta, Van Anh ; Cohen, Elisabeth ; Ram-Wolff, Caroline ; Bozonnat, Alizée ; Battesti, Gilles ; Louveau, Baptiste ; Mourah, Samia ; Battistella, Maxime ; Moins-Teisserenc, Hélène ; de Masson, Adèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c247t-ad440c17d44302bbc1614f13b112dd8d14e60a10f21d023da6214c364a4606013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Antibodies, Monoclonal, Humanized - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Lymphoma, T-Cell, Cutaneous - drug therapy</topic><topic>Lymphoma, T-Cell, Cutaneous - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Receptors, CCR4 - antagonists & inhibitors</topic><topic>Receptors, CCR4 - metabolism</topic><topic>Skin Neoplasms - drug therapy</topic><topic>Skin Neoplasms - pathology</topic><topic>Treatment Failure</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stammler, Romain</creatorcontrib><creatorcontrib>Ta, Van Anh</creatorcontrib><creatorcontrib>Cohen, Elisabeth</creatorcontrib><creatorcontrib>Ram-Wolff, Caroline</creatorcontrib><creatorcontrib>Bozonnat, Alizée</creatorcontrib><creatorcontrib>Battesti, Gilles</creatorcontrib><creatorcontrib>Louveau, Baptiste</creatorcontrib><creatorcontrib>Mourah, Samia</creatorcontrib><creatorcontrib>Battistella, Maxime</creatorcontrib><creatorcontrib>Moins-Teisserenc, Hélène</creatorcontrib><creatorcontrib>de Masson, Adèle</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stammler, Romain</au><au>Ta, Van Anh</au><au>Cohen, Elisabeth</au><au>Ram-Wolff, Caroline</au><au>Bozonnat, Alizée</au><au>Battesti, Gilles</au><au>Louveau, Baptiste</au><au>Mourah, Samia</au><au>Battistella, Maxime</au><au>Moins-Teisserenc, Hélène</au><au>de Masson, Adèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Failure of second challenge with mogamulizumab in C-C chemokine receptor 4-positive cutaneous T-cell lymphoma</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>2024-05-17</date><risdate>2024</risdate><volume>190</volume><issue>6</issue><spage>920</spage><epage>921</epage><pages>920-921</pages><issn>0007-0963</issn><issn>1365-2133</issn><eissn>1365-2133</eissn><abstract>We report three patients with Sézary syndrome who had previously been successfully treated with mogamulizumab and then failed a second course of the same treatment, despite positive CCR4 expression at the second initiation of mogamulizumab. 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| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 2024-05, Vol.190 (6), p.920-921 |
| issn | 0007-0963 1365-2133 1365-2133 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current) |
| subjects | Aged Antibodies, Monoclonal, Humanized - adverse effects Female Humans Lymphoma, T-Cell, Cutaneous - drug therapy Lymphoma, T-Cell, Cutaneous - pathology Male Middle Aged Receptors, CCR4 - antagonists & inhibitors Receptors, CCR4 - metabolism Skin Neoplasms - drug therapy Skin Neoplasms - pathology Treatment Failure |
| title | Failure of second challenge with mogamulizumab in C-C chemokine receptor 4-positive cutaneous T-cell lymphoma |
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