Molecular mechanism of α-synuclein aggregation on lipid membranes revealed

The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable in vitro , but its aggregation can be triggered by the presence of lipid vesic...

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Veröffentlicht in:	Chemical science (Cambridge) 2024-05, Vol.15 (19), p.7229-7242
Hauptverfasser:	Dear, Alexander J, Teng, Xiangyu, Ball, Sarah R, Lewin, Joshua, Horne, Robert I, Clow, Daniel, Stevenson, Alisdair, Harper, Natasha, Yahya, Kim, Yang, Xiaoting, Brewerton, Suzanne C, Thomson, John, Michaels, Thomas C. T, Linse, Sara, Knowles, Tuomas P. J, Habchi, Johnny, Meisl, Georg
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Chemistry Fysikalisk kemi Kemi Lipids Membranes Model forms Natural Sciences Naturvetenskap Nucleation Parkinson's disease Physical Chemistry Proteins Reaction kinetics Vesicles
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