Structural diversity of decalin forming Diels-Alderase

Structural diversity of decalin forming Diels-Alderase

The Diels-Alder (DA) reaction, specifically referring to the [4 + 2] cycloaddition reaction in pericyclic reactions, is a process that forms two carbon-carbon covalent bonds in a single step via an electron ring transition state. Among the secondary metabolites produced by microorganisms, numerous c...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2024-06, Vol.88 (7), p.719-726
1. Verfasser: Sato, Michio
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Sprache:eng
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Cycloaddition Reaction
Fungal Proteins - chemistry
Fungal Proteins - metabolism
Fungi - enzymology
Naphthalenes - chemistry
Naphthalenes - metabolism
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creator Sato, Michio
description The Diels-Alder (DA) reaction, specifically referring to the [4 + 2] cycloaddition reaction in pericyclic reactions, is a process that forms two carbon-carbon covalent bonds in a single step via an electron ring transition state. Among the secondary metabolites produced by microorganisms, numerous compounds are biosynthesized through DA reactions, most of which are enzymatic. Our research group has discovered an enzyme named Diels-Alderase (DAase) that catalyzes the DA reaction in filamentous fungi, and we have been investigating its catalytic mechanism. This review describes the reported microbial DAase enzymes, with a particular focus on those involved in the construction of the decalin ring.
doi_str_mv 10.1093/bbb/zbae040
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subjects Cycloaddition Reaction
Fungal Proteins - chemistry
Fungal Proteins - metabolism
Fungi - enzymology
Naphthalenes - chemistry
Naphthalenes - metabolism
title Structural diversity of decalin forming Diels-Alderase
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