A novel suppressor of Piezo2 in rodent nociceptors
Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular con...
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| Veröffentlicht in: | Trends in neurosciences (Regular ed.) 2024-07, Vol.47 (7), p.478-479 |
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| container_title | Trends in neurosciences (Regular ed.) |
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| creator | West, Aaron Keith Schneider, Eve Rebecca |
| description | Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular context for Piezo2 channels in normal and pathological responses to mechanical pain.
Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular context for Piezo2 channels in normal and pathological responses to mechanical pain. |
| doi_str_mv | 10.1016/j.tins.2024.05.003 |
| format | Article |
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Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular context for Piezo2 channels in normal and pathological responses to mechanical pain.</description><identifier>ISSN: 0166-2236</identifier><identifier>ISSN: 1878-108X</identifier><identifier>EISSN: 1878-108X</identifier><identifier>DOI: 10.1016/j.tins.2024.05.003</identifier><identifier>PMID: 38762363</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>allodynia ; Animals ; Humans ; hyperalgesia ; Ion Channels - metabolism ; mechanosensation ; Mechanotransduction, Cellular - physiology ; Nociceptors - metabolism ; Nociceptors - physiology ; Pain - metabolism ; Pain - physiopathology ; Piezo ; Rodentia ; touch ; transmembrane-like channels</subject><ispartof>Trends in neurosciences (Regular ed.), 2024-07, Vol.47 (7), p.478-479</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c307t-dcdeb5fa6ab69b92450bc680c824a249a635fc45fc2283b0da7c4c94e1270e3b3</cites><orcidid>0000-0002-0998-4363</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tins.2024.05.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38762363$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>West, Aaron Keith</creatorcontrib><creatorcontrib>Schneider, Eve Rebecca</creatorcontrib><title>A novel suppressor of Piezo2 in rodent nociceptors</title><title>Trends in neurosciences (Regular ed.)</title><addtitle>Trends Neurosci</addtitle><description>Members of both the Piezo and transmembrane channel-like (TMC) families are bona fide mammalian mechanotransducers. In a recent study, Zhang, Shao et al. discovered that TMC7, a non-mechanosensitive TMC, inhibits Piezo2-dependent mechanosensation, with implications for the importance of cellular context for Piezo2 channels in normal and pathological responses to mechanical pain.
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| ispartof | Trends in neurosciences (Regular ed.), 2024-07, Vol.47 (7), p.478-479 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | allodynia Animals Humans hyperalgesia Ion Channels - metabolism mechanosensation Mechanotransduction, Cellular - physiology Nociceptors - metabolism Nociceptors - physiology Pain - metabolism Pain - physiopathology Piezo Rodentia touch transmembrane-like channels |
| title | A novel suppressor of Piezo2 in rodent nociceptors |
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