Oxidative stress in peroxisomes induced by androgen receptor inhibition through peroxisome proliferator–activated receptor promotes enzalutamide resistance in prostate cancer

Androgen receptor (AR)-targeting therapy induces oxidative stress in prostate cancer. However, the mechanism of oxidative stress induction by AR-targeting therapy remains unclear. This study investigated the mechanism of oxidative stress induction by AR-targeting therapy, with the aim to develop nov...

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Veröffentlicht in:	Free radical biology & medicine 2024-08, Vol.221, p.81-88
Hauptverfasser:	Shiota, Masaki, Ushijima, Miho, Tsukahara, Shigehiro, Nagakawa, Shohei, Okada, Tatsunori, Tanegashima, Tokiyoshi, Kobayashi, Satoshi, Matsumoto, Takashi, Eto, Masatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgen Receptor Antagonists - pharmacology Benzamides - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Drug Resistance, Neoplasm - drug effects Enzalutamide Gene Expression Regulation, Neoplastic - drug effects Humans Male Nitriles - pharmacology Oxidative stress Oxidative Stress - drug effects Peroxisome Peroxisomes - drug effects Peroxisomes - metabolism Phenylthiohydantoin - pharmacology PPAR PPAR alpha - genetics PPAR alpha - metabolism Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Reactive Oxygen Species - metabolism Receptors, Androgen - genetics Receptors, Androgen - metabolism RNA, Small Interfering - genetics Signal Transduction - drug effects
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