Development of new steroid-based hydrazide and (thio)semicarbazone compounds with anticancer properties

Most breast and prostate cancers are caused by abnormal production or action of steroidal hormones. Hormonal drugs based on steroid scaffolds represent a significant class of chemotherapeutics that are routinely used in chemotherapy. In this study, the synthesis of new 17a-homo lactone and 17α-(pyri...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2024-09, Vol.242, p.106545, Article 106545
Hauptverfasser:	Janković, Ðorđe D., Šestić, Tijana Lj, Bekić, Sofija S., Savić, Marina P., Ćelić, Andjelka S., Scholda, Julia, Kopp, Florian, Marinović, Maja A., Petri, Edward T., Ajduković, Jovana J.
Format:	Artikel
Sprache:	eng
Schlagworte:	AKR1C Androstane Anti-proliferative activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Survival - drug effects Drug Screening Assays, Antitumor Hormone receptors Humans Hydrazide Hydrazines - chemistry Hydrazines - pharmacology Molecular Docking Simulation Semicarbazone Semicarbazones - chemical synthesis Semicarbazones - chemistry Semicarbazones - pharmacology Steroids - chemistry Steroids - pharmacology Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology
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