Do neutrophil/lymphocyte, monocyte/lymphocyte, platelet/lymphocyte ratios affect prognosis and stage in avascular necrosis of the femoral head?
Avascular necrosis of the femoral head (AVNFH) is an osteonecrosis type caused by ischaemic osteocyte loss of femoral head, and its exact pathomechanism is still unknown. Neutrophil, lymphocyte, monocyte, platelet levels in complete blood count and ratios between these levels have been used by almos...
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| Veröffentlicht in: | Bratislava Medical Journal 2024, Vol.125 (6), p.387-391 |
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| description | Avascular necrosis of the femoral head (AVNFH) is an osteonecrosis type caused by ischaemic osteocyte loss of femoral head, and its exact pathomechanism is still unknown. Neutrophil, lymphocyte, monocyte, platelet levels in complete blood count and ratios between these levels have been used by almost all medical disciplines as accesible and reliable biomarkers of immune response. Aim of this study is to identify the effects of neutrophil/lymphocyte (NL), monocyte/lymphocyte (ML), platelet/lymphocyte (PLT/L) ratios on prognosis and stage in patients with avascular necrosis of the femoral head (AVNFH).
A total of 106 (30 female; 76 male) patients aged 18 and over diagnosed with avascular necrosis of femoral head between 2012-2022 years were retrospectively evaluated. Study was planned after a total of 106 (30 female, 76 male) healthy patients with consent to participate who were demographically equal to the study group were included in the control group. Patients in the study group were divided into 3 groups as Stage I, II and III according to the Ficat-Arlet classification.
In terms of neutrophil counts; neutrophil values of study and control groups were 4.94±1.89 and 4,21±1,17; respectively. There was statistically significant difference between counts (p |
| doi_str_mv | 10.4149/BLL_2024_59 |
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A total of 106 (30 female; 76 male) patients aged 18 and over diagnosed with avascular necrosis of femoral head between 2012-2022 years were retrospectively evaluated. Study was planned after a total of 106 (30 female, 76 male) healthy patients with consent to participate who were demographically equal to the study group were included in the control group. Patients in the study group were divided into 3 groups as Stage I, II and III according to the Ficat-Arlet classification.
In terms of neutrophil counts; neutrophil values of study and control groups were 4.94±1.89 and 4,21±1,17; respectively. There was statistically significant difference between counts (p<0.05). In terms of neutrophil/lymphocyte ratio, NL ratio was statistically significantly higher in study group (2.11±0.85) than control group (1.75±0.44). Cut-off value of NL ratio was 2.13 according to the ROC analysis (sensitivity 47.17% (95% CI (37.4-57.1)); specificity=84.91% 95% GA (76.6-91.1)). Sensitivity and specificity of cut-off value was statistically significant. There was no difference between groups created according to Ficat-Arlet in terms of hemogram parameters.
NL may indicate AVNFH; however, other parameters are considered as inadequate for identifying an independent marker in AVNFH due to ineffective immune response. Future studies with larger samples which allow standard and multi-dimensional analysis are needed (Tab. 4, Fig. 5, Ref. 20).</description><identifier>ISSN: 0006-9248</identifier><identifier>ISSN: 1336-0345</identifier><identifier>EISSN: 1336-0345</identifier><identifier>DOI: 10.4149/BLL_2024_59</identifier><identifier>PMID: 38757597</identifier><language>eng</language><publisher>Slovakia</publisher><subject>Adult ; Biomarkers - blood ; Blood Platelets - pathology ; Female ; Femur Head Necrosis - blood ; Femur Head Necrosis - pathology ; Humans ; Leukocyte Count ; Lymphocyte Count ; Lymphocytes - pathology ; Male ; Middle Aged ; Monocytes - pathology ; Neutrophils - pathology ; Platelet Count ; Prognosis ; Retrospective Studies</subject><ispartof>Bratislava Medical Journal, 2024, Vol.125 (6), p.387-391</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,4010,27904,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38757597$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gokalp, Alp Yekta</creatorcontrib><creatorcontrib>Tekin, Sezgin Bahadir</creatorcontrib><title>Do neutrophil/lymphocyte, monocyte/lymphocyte, platelet/lymphocyte ratios affect prognosis and stage in avascular necrosis of the femoral head?</title><title>Bratislava Medical Journal</title><addtitle>Bratisl Lek Listy</addtitle><description>Avascular necrosis of the femoral head (AVNFH) is an osteonecrosis type caused by ischaemic osteocyte loss of femoral head, and its exact pathomechanism is still unknown. Neutrophil, lymphocyte, monocyte, platelet levels in complete blood count and ratios between these levels have been used by almost all medical disciplines as accesible and reliable biomarkers of immune response. Aim of this study is to identify the effects of neutrophil/lymphocyte (NL), monocyte/lymphocyte (ML), platelet/lymphocyte (PLT/L) ratios on prognosis and stage in patients with avascular necrosis of the femoral head (AVNFH).
A total of 106 (30 female; 76 male) patients aged 18 and over diagnosed with avascular necrosis of femoral head between 2012-2022 years were retrospectively evaluated. Study was planned after a total of 106 (30 female, 76 male) healthy patients with consent to participate who were demographically equal to the study group were included in the control group. Patients in the study group were divided into 3 groups as Stage I, II and III according to the Ficat-Arlet classification.
In terms of neutrophil counts; neutrophil values of study and control groups were 4.94±1.89 and 4,21±1,17; respectively. There was statistically significant difference between counts (p<0.05). In terms of neutrophil/lymphocyte ratio, NL ratio was statistically significantly higher in study group (2.11±0.85) than control group (1.75±0.44). Cut-off value of NL ratio was 2.13 according to the ROC analysis (sensitivity 47.17% (95% CI (37.4-57.1)); specificity=84.91% 95% GA (76.6-91.1)). Sensitivity and specificity of cut-off value was statistically significant. There was no difference between groups created according to Ficat-Arlet in terms of hemogram parameters.
NL may indicate AVNFH; however, other parameters are considered as inadequate for identifying an independent marker in AVNFH due to ineffective immune response. Future studies with larger samples which allow standard and multi-dimensional analysis are needed (Tab. 4, Fig. 5, Ref. 20).</description><subject>Adult</subject><subject>Biomarkers - blood</subject><subject>Blood Platelets - pathology</subject><subject>Female</subject><subject>Femur Head Necrosis - blood</subject><subject>Femur Head Necrosis - pathology</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Lymphocyte Count</subject><subject>Lymphocytes - pathology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monocytes - pathology</subject><subject>Neutrophils - pathology</subject><subject>Platelet Count</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><issn>0006-9248</issn><issn>1336-0345</issn><issn>1336-0345</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUlPwzAQhS0EgrKcuCMfkSDUiZfYJwRllSpxgXPkJuM2yImD7SD1V_CXSRcQnGb05tPM0zyETlNyxVKmxrfTaZGRjBVc7aBRSqlICGV8F40IISJRGZMH6DCEd0IY5anYRwdU5jznKh-hrzuHW-ijd92itmO7bLqFK5cRLnHj2nX3T-ysjmAh_hGx17F2AWtjoIy4827eulAPQlvhEPUccN1i_alD2Vvth3OlX8-dwXEB2EDjvLZ4Abq6PkZ7RtsAJ9t6hN4e7l8nT8n05fF5cjNNykyymKREzWQljRIKdA6GCaWUgJIrQwhnMqVSVCI3GcsNByJoKaXJUgMVoVIqTo_Q-WbvYPejhxCLpg4lWKtbcH0oKOFCCJrnckAvNujKdvBgis7XjfbLIiXFKoHiTwIDfbZd3M8aqH7Zn5fTbxeshDg</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Gokalp, Alp Yekta</creator><creator>Tekin, Sezgin Bahadir</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2024</creationdate><title>Do neutrophil/lymphocyte, monocyte/lymphocyte, platelet/lymphocyte ratios affect prognosis and stage in avascular necrosis of the femoral head?</title><author>Gokalp, Alp Yekta ; Tekin, Sezgin Bahadir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c284t-109b8d8f969ea7ef469996ec59f005481386d67f247f5e063c88f21fed0388953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Biomarkers - blood</topic><topic>Blood Platelets - pathology</topic><topic>Female</topic><topic>Femur Head Necrosis - blood</topic><topic>Femur Head Necrosis - pathology</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Lymphocyte Count</topic><topic>Lymphocytes - pathology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monocytes - pathology</topic><topic>Neutrophils - pathology</topic><topic>Platelet Count</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gokalp, Alp Yekta</creatorcontrib><creatorcontrib>Tekin, Sezgin Bahadir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bratislava Medical Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gokalp, Alp Yekta</au><au>Tekin, Sezgin Bahadir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do neutrophil/lymphocyte, monocyte/lymphocyte, platelet/lymphocyte ratios affect prognosis and stage in avascular necrosis of the femoral head?</atitle><jtitle>Bratislava Medical Journal</jtitle><addtitle>Bratisl Lek Listy</addtitle><date>2024</date><risdate>2024</risdate><volume>125</volume><issue>6</issue><spage>387</spage><epage>391</epage><pages>387-391</pages><issn>0006-9248</issn><issn>1336-0345</issn><eissn>1336-0345</eissn><abstract>Avascular necrosis of the femoral head (AVNFH) is an osteonecrosis type caused by ischaemic osteocyte loss of femoral head, and its exact pathomechanism is still unknown. Neutrophil, lymphocyte, monocyte, platelet levels in complete blood count and ratios between these levels have been used by almost all medical disciplines as accesible and reliable biomarkers of immune response. Aim of this study is to identify the effects of neutrophil/lymphocyte (NL), monocyte/lymphocyte (ML), platelet/lymphocyte (PLT/L) ratios on prognosis and stage in patients with avascular necrosis of the femoral head (AVNFH).
A total of 106 (30 female; 76 male) patients aged 18 and over diagnosed with avascular necrosis of femoral head between 2012-2022 years were retrospectively evaluated. Study was planned after a total of 106 (30 female, 76 male) healthy patients with consent to participate who were demographically equal to the study group were included in the control group. Patients in the study group were divided into 3 groups as Stage I, II and III according to the Ficat-Arlet classification.
In terms of neutrophil counts; neutrophil values of study and control groups were 4.94±1.89 and 4,21±1,17; respectively. There was statistically significant difference between counts (p<0.05). In terms of neutrophil/lymphocyte ratio, NL ratio was statistically significantly higher in study group (2.11±0.85) than control group (1.75±0.44). Cut-off value of NL ratio was 2.13 according to the ROC analysis (sensitivity 47.17% (95% CI (37.4-57.1)); specificity=84.91% 95% GA (76.6-91.1)). Sensitivity and specificity of cut-off value was statistically significant. There was no difference between groups created according to Ficat-Arlet in terms of hemogram parameters.
NL may indicate AVNFH; however, other parameters are considered as inadequate for identifying an independent marker in AVNFH due to ineffective immune response. Future studies with larger samples which allow standard and multi-dimensional analysis are needed (Tab. 4, Fig. 5, Ref. 20).</abstract><cop>Slovakia</cop><pmid>38757597</pmid><doi>10.4149/BLL_2024_59</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biomarkers - blood Blood Platelets - pathology Female Femur Head Necrosis - blood Femur Head Necrosis - pathology Humans Leukocyte Count Lymphocyte Count Lymphocytes - pathology Male Middle Aged Monocytes - pathology Neutrophils - pathology Platelet Count Prognosis Retrospective Studies |
| title | Do neutrophil/lymphocyte, monocyte/lymphocyte, platelet/lymphocyte ratios affect prognosis and stage in avascular necrosis of the femoral head? |
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