Adenylate kinase phosphate energy shuttle underlies energetic communication in flagellar axonemes

The complexities of energy transfer mechanisms in the flagella of mammalian sperm flagella have been intensively investigated and demonstrate significant diversity across species. Enzymatic shuttles, particularly adenylate kinase (AK) and creatine kinase (CK), are pivotal in the efficient transfer o...

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Veröffentlicht in:	Science China. Life sciences 2024-08, Vol.67 (8), p.1697-1714
Hauptverfasser:	Wu, Huan, Zhang, Yanman, Li, Yuqian, Sun, Shuya, Zhang, Jintao, Xie, Qingsong, Dong, Yue, Zhou, Shushu, Sha, Xuan, Li, Kuokuo, Chen, Jinyi, Zhang, Xin, Gao, Yang, Shen, Qunshan, Wang, Guanxiong, Zha, Xiaomin, Duan, Zongliu, Tang, Dongdong, Xu, Chuan, Geng, Hao, Lv, Mingrong, Xu, Yuping, Zhou, Ping, Wei, Zhaolian, Hua, Rong, Cao, Yunxia, Liu, Mingxi, He, Xiaojin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Adenylate kinase Adenylate Kinase - metabolism Animal models Animals Axoneme - metabolism Axonemes Biomedical and Life Sciences Creatine Creatine kinase Creatine Kinase - metabolism Energy consumption Energy Metabolism Flagella Flagella - metabolism Humans Immunoprecipitation Infertility, Male - genetics Infertility, Male - metabolism Intracellular signalling Kinases Life Sciences Male Mass spectroscopy Metabolomics Mice Mice, Knockout Reproductive system Research Paper Sperm Sperm Motility - physiology Sperm Tail - metabolism Spermatozoa - metabolism
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