Early effectiveness of local injection of multimodal drug cocktail during anterior cruciate ligament reconstruction and its influence on cartilage
To explore the early effectiveness and influence on cartilage of local injection of multimodal drug cocktail (MDC) during anterior cruciate ligament reconstruction (ACLR). Between February 2022 and August 2023, patients undergone arthroscopic ACLR using autologous hamstring tendons were selected as...
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| Veröffentlicht in: | Zhongguo xiu fu chong jian wai ke za zhi 2024-05, Vol.38 (5), p.562 |
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| container_title | Zhongguo xiu fu chong jian wai ke za zhi |
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| creator | Yu, Hong Dong, Zhenlin Shi, Zhengliang Li, Li Dong, Kaiyan Liu, Haolong Li, Yanlin |
| description | To explore the early effectiveness and influence on cartilage of local injection of multimodal drug cocktail (MDC) during anterior cruciate ligament reconstruction (ACLR).
Between February 2022 and August 2023, patients undergone arthroscopic ACLR using autologous hamstring tendons were selected as the study subjects. Among them, 90 patients met the selection criteria and were randomly divided into 3 groups (
=30) according to the different injection drugs after ligament reconstruction. There was no significant difference in baseline data such as gender, age, body mass index, surgical side, disease duration, preoperative thigh circumference, and preoperative levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1, matrix metalloproteinase 3 (MMP-3), MMP-13, and aggrecan (ACAN) in synovial fluid between groups (
>0.05). After the ligament reconstruction during operation, corresponding MDC (consisting of ropivacaine, tranexamic acid, and betamethasone in group A, and ropivacaine, betamethasone, an |
| doi_str_mv | 10.7507/1002-1892.202402054 |
| format | Article |
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Between February 2022 and August 2023, patients undergone arthroscopic ACLR using autologous hamstring tendons were selected as the study subjects. Among them, 90 patients met the selection criteria and were randomly divided into 3 groups (
=30) according to the different injection drugs after ligament reconstruction. There was no significant difference in baseline data such as gender, age, body mass index, surgical side, disease duration, preoperative thigh circumference, and preoperative levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1, matrix metalloproteinase 3 (MMP-3), MMP-13, and aggrecan (ACAN) in synovial fluid between groups (
>0.05). After the ligament reconstruction during operation, corresponding MDC (consisting of ropivacaine, tranexamic acid, and betamethasone in group A, and ropivacaine, betamethasone, an</description><identifier>ISSN: 1002-1892</identifier><identifier>DOI: 10.7507/1002-1892.202402054</identifier><identifier>PMID: 38752242</identifier><language>chi</language><publisher>China</publisher><subject>Adult ; Aggrecans - metabolism ; Anesthetics, Local - administration & dosage ; Anterior Cruciate Ligament - surgery ; Anterior Cruciate Ligament Injuries - surgery ; Anterior Cruciate Ligament Reconstruction - methods ; Arthroscopy ; Betamethasone - administration & dosage ; Cartilage - metabolism ; Female ; Humans ; Male ; Matrix Metalloproteinase 13 - metabolism ; Matrix Metalloproteinase 3 - metabolism ; Ropivacaine - administration & dosage ; Tendons - transplantation ; Treatment Outcome ; Tumor Necrosis Factor-alpha - metabolism</subject><ispartof>Zhongguo xiu fu chong jian wai ke za zhi, 2024-05, Vol.38 (5), p.562</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38752242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Hong</creatorcontrib><creatorcontrib>Dong, Zhenlin</creatorcontrib><creatorcontrib>Shi, Zhengliang</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Dong, Kaiyan</creatorcontrib><creatorcontrib>Liu, Haolong</creatorcontrib><creatorcontrib>Li, Yanlin</creatorcontrib><title>Early effectiveness of local injection of multimodal drug cocktail during anterior cruciate ligament reconstruction and its influence on cartilage</title><title>Zhongguo xiu fu chong jian wai ke za zhi</title><addtitle>Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi</addtitle><description>To explore the early effectiveness and influence on cartilage of local injection of multimodal drug cocktail (MDC) during anterior cruciate ligament reconstruction (ACLR).
Between February 2022 and August 2023, patients undergone arthroscopic ACLR using autologous hamstring tendons were selected as the study subjects. Among them, 90 patients met the selection criteria and were randomly divided into 3 groups (
=30) according to the different injection drugs after ligament reconstruction. There was no significant difference in baseline data such as gender, age, body mass index, surgical side, disease duration, preoperative thigh circumference, and preoperative levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1, matrix metalloproteinase 3 (MMP-3), MMP-13, and aggrecan (ACAN) in synovial fluid between groups (
>0.05). After the ligament reconstruction during operation, corresponding MDC (consisting of ropivacaine, tranexamic acid, and betamethasone in group A, and ropivacaine, betamethasone, an</description><subject>Adult</subject><subject>Aggrecans - metabolism</subject><subject>Anesthetics, Local - administration & dosage</subject><subject>Anterior Cruciate Ligament - surgery</subject><subject>Anterior Cruciate Ligament Injuries - surgery</subject><subject>Anterior Cruciate Ligament Reconstruction - methods</subject><subject>Arthroscopy</subject><subject>Betamethasone - administration & dosage</subject><subject>Cartilage - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Matrix Metalloproteinase 13 - metabolism</subject><subject>Matrix Metalloproteinase 3 - metabolism</subject><subject>Ropivacaine - administration & dosage</subject><subject>Tendons - transplantation</subject><subject>Treatment Outcome</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><issn>1002-1892</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1KAzEUhbNQbKl9AkGydNOa_0mXUuoPFNzouqSZOyWaSWqSEfoaPrGpVleX83H44FyEriiZN5I0t5QQNqN6weaMMEEYkeIMjf_pCE1zdlsiKVdaSH6BRlw3kjHBxuhrZZI_YOg6sMV9QoCcceywj9Z47MLbEcdwRP3gi-tjW3mbhh220b4X42oakgs7bEKB5GLCNg3WmQLYu53pIRScwMaQS-U_MhNa7Equ-s4PECzgCq1JxXmzg0t03hmfYXq6E_R6v3pZPs7Wzw9Py7v1bE-ZKrPO1qlak65lTWtlY7WSLZNa0Dqu4UIrpQStI8XWUNZsOadWKAGWNEaTBeUTdPPr3af4MUAum95lC96bAHHIG06k1AupiKrV61N12PbQbvbJ9SYdNn9_5N9OyHZh</recordid><startdate>20240515</startdate><enddate>20240515</enddate><creator>Yu, Hong</creator><creator>Dong, Zhenlin</creator><creator>Shi, Zhengliang</creator><creator>Li, Li</creator><creator>Dong, Kaiyan</creator><creator>Liu, Haolong</creator><creator>Li, Yanlin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20240515</creationdate><title>Early effectiveness of local injection of multimodal drug cocktail during anterior cruciate ligament reconstruction and its influence on cartilage</title><author>Yu, Hong ; Dong, Zhenlin ; Shi, Zhengliang ; Li, Li ; Dong, Kaiyan ; Liu, Haolong ; Li, Yanlin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-fc402880fd27dc57c865d258418757348666412424ba127b331c464ec07a80913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aggrecans - metabolism</topic><topic>Anesthetics, Local - administration & dosage</topic><topic>Anterior Cruciate Ligament - surgery</topic><topic>Anterior Cruciate Ligament Injuries - surgery</topic><topic>Anterior Cruciate Ligament Reconstruction - methods</topic><topic>Arthroscopy</topic><topic>Betamethasone - administration & dosage</topic><topic>Cartilage - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Matrix Metalloproteinase 13 - metabolism</topic><topic>Matrix Metalloproteinase 3 - metabolism</topic><topic>Ropivacaine - administration & dosage</topic><topic>Tendons - transplantation</topic><topic>Treatment Outcome</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Hong</creatorcontrib><creatorcontrib>Dong, Zhenlin</creatorcontrib><creatorcontrib>Shi, Zhengliang</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Dong, Kaiyan</creatorcontrib><creatorcontrib>Liu, Haolong</creatorcontrib><creatorcontrib>Li, Yanlin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhongguo xiu fu chong jian wai ke za zhi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Hong</au><au>Dong, Zhenlin</au><au>Shi, Zhengliang</au><au>Li, Li</au><au>Dong, Kaiyan</au><au>Liu, Haolong</au><au>Li, Yanlin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early effectiveness of local injection of multimodal drug cocktail during anterior cruciate ligament reconstruction and its influence on cartilage</atitle><jtitle>Zhongguo xiu fu chong jian wai ke za zhi</jtitle><addtitle>Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi</addtitle><date>2024-05-15</date><risdate>2024</risdate><volume>38</volume><issue>5</issue><spage>562</spage><pages>562-</pages><issn>1002-1892</issn><abstract>To explore the early effectiveness and influence on cartilage of local injection of multimodal drug cocktail (MDC) during anterior cruciate ligament reconstruction (ACLR).
Between February 2022 and August 2023, patients undergone arthroscopic ACLR using autologous hamstring tendons were selected as the study subjects. Among them, 90 patients met the selection criteria and were randomly divided into 3 groups (
=30) according to the different injection drugs after ligament reconstruction. There was no significant difference in baseline data such as gender, age, body mass index, surgical side, disease duration, preoperative thigh circumference, and preoperative levels of tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), IL-1, matrix metalloproteinase 3 (MMP-3), MMP-13, and aggrecan (ACAN) in synovial fluid between groups (
>0.05). After the ligament reconstruction during operation, corresponding MDC (consisting of ropivacaine, tranexamic acid, and betamethasone in group A, and ropivacaine, betamethasone, an</abstract><cop>China</cop><pmid>38752242</pmid><doi>10.7507/1002-1892.202402054</doi></addata></record> |
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| ispartof | Zhongguo xiu fu chong jian wai ke za zhi, 2024-05, Vol.38 (5), p.562 |
| issn | 1002-1892 |
| language | chi |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adult Aggrecans - metabolism Anesthetics, Local - administration & dosage Anterior Cruciate Ligament - surgery Anterior Cruciate Ligament Injuries - surgery Anterior Cruciate Ligament Reconstruction - methods Arthroscopy Betamethasone - administration & dosage Cartilage - metabolism Female Humans Male Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 3 - metabolism Ropivacaine - administration & dosage Tendons - transplantation Treatment Outcome Tumor Necrosis Factor-alpha - metabolism |
| title | Early effectiveness of local injection of multimodal drug cocktail during anterior cruciate ligament reconstruction and its influence on cartilage |
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