Toll-like receptor 9 signaling is associated with immune responses to Trypanosoma brucei infection

•A mutation at the 359th amino acid of TLR9 inhibits the expansion of splenic T cells during Trypanosoma brucei infection.•The MAPK signaling pathway was suppressed and cytokine production reduced in Tlr9M7Btlr mice during trypanosome infection.•Trypanosome DNA activates the MAPK signaling pathways...

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