A mathematical model on the propagation of tau pathology in neurodegenerative diseases

A system of partial differential equations is developed to study the spreading of tau pathology in the brain for Alzheimer’s and other neurodegenerative diseases. Two cases are considered with one assuming intracellular diffusion through synaptic activities or the nanotubes that connect the adjacent...

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Veröffentlicht in:	Journal of mathematical biology 2024-07, Vol.89 (1), p.4, Article 4
Hauptverfasser:	Chen, C. Y., Tseng, Y. H., Ward, J. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Applications of Mathematics Brain Brain - metabolism Brain - pathology Computer Simulation Differential equations Disease Disease Progression Fluid flow Humans Intracellular Mathematical and Computational Biology Mathematical Concepts Mathematical models Mathematics Mathematics and Statistics Membranes Models, Biological Models, Neurological Nanotechnology Nanotubes Neurodegenerative diseases Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurofibrillary tangles Neurofibrillary Tangles - metabolism Neurofibrillary Tangles - pathology Partial differential equations Pathology Spreading Tau protein tau Proteins - metabolism Tauopathies - metabolism Tauopathies - pathology Traveling waves
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