Influence of Tranexamic Acid in Body Contouring Surgery: Significant Changes on Complication Rates after Abdominoplasty
Background Complications after abdominoplasty remain an unsolved issue in body contouring surgery. The antifibrinolytic drug tranexamic acid (TXA) has gained increasing recognition as a valuable pharmacologic agent within plastic surgery. The aim of this study was to investigate the influence of int...
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| Veröffentlicht in: | Aesthetic plastic surgery 2024-08, Vol.48 (15), p.2872-2878 |
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| creator | Zaussinger, Maximilian Kerschbaumer, Celina Schwartz, Bernhard Bachleitner, Kathrin Ehebruster, Gudrun Schmidt, Manfred |
| description | Background
Complications after abdominoplasty remain an unsolved issue in body contouring surgery. The antifibrinolytic drug tranexamic acid (TXA) has gained increasing recognition as a valuable pharmacologic agent within plastic surgery. The aim of this study was to investigate the influence of intravenously administered TXA on complications and patient safety after abdominoplasty.
Methods
Within this retrospective single-center study, patients who underwent abdominoplasty and received intravenous TXA were selected and compared to randomly selected patients who underwent abdominoplasty without administration of TXA. The patient population was divided into two study groups (TXA vs no TXA). Demographic and surgical data as well as complications were evaluated and compared. Appropriate statistical analysis was performed.
Results
Fifty-seven female and 3 male patients with a median age of 38 years and a mean BMI of 25.6 ± 3.3 kg/m
2
were included in the study. Except smoking history, demographic data showed no statistically significant differences between both groups. The most common complication was seroma formation (
n
= 16; 23.9%), and its occurrence was statistically significantly lower in the TXA group (
p
= 0.023). Furthermore, postoperative seroma aspiration was performed in statistically significant lower numbers in the TXA group (
p |
| doi_str_mv | 10.1007/s00266-024-04094-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3055894410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3089037567</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-77001b54fb0d895731a20de9352385bc4337f311a58f7cabfb81baf86bccffe33</originalsourceid><addsrcrecordid>eNp9kU2L1TAUhoMoznX0D7iQgBs31ZOvpnV3vfgxMCA4I7gLSZpcM7RJTVq0_96Md1Rw4Srk8Jw35-RB6CmBlwRAvioAtG0boLwBDj1vtntoRzijjaCc3Ec7YC1vKGm_nKFHpdwAEColf4jOWCcFUNru0PeL6MfVRetw8vg66-h-6ClYvLdhwCHiN2nY8CHFJa05xCO-WvPR5e01vgrHGHywOi748FXHoys4xYpO81irS6iXT3qpVe0Xl_HeDGkKMc2jLsv2GD3weizuyd15jj6_e3t9-NBcfnx_cdhfNpbRdmmkrEMbwb2BoeuFZERTGFzPBGWdMJYzJj0jRIvOS6uNNx0x2netsdZ7x9g5enHKnXP6trqyqCkU68axLprWohgI0fWcE6jo83_Qm7pzrNNVquuBSdHKStETZXMqJTuv5hwmnTdFQN1qUSctqmpRv7SorTY9u4tezeSGPy2_PVSAnYAy3_6yy3_f_k_sT7uCmag</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3089037567</pqid></control><display><type>article</type><title>Influence of Tranexamic Acid in Body Contouring Surgery: Significant Changes on Complication Rates after Abdominoplasty</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Zaussinger, Maximilian ; Kerschbaumer, Celina ; Schwartz, Bernhard ; Bachleitner, Kathrin ; Ehebruster, Gudrun ; Schmidt, Manfred</creator><creatorcontrib>Zaussinger, Maximilian ; Kerschbaumer, Celina ; Schwartz, Bernhard ; Bachleitner, Kathrin ; Ehebruster, Gudrun ; Schmidt, Manfred</creatorcontrib><description>Background
Complications after abdominoplasty remain an unsolved issue in body contouring surgery. The antifibrinolytic drug tranexamic acid (TXA) has gained increasing recognition as a valuable pharmacologic agent within plastic surgery. The aim of this study was to investigate the influence of intravenously administered TXA on complications and patient safety after abdominoplasty.
Methods
Within this retrospective single-center study, patients who underwent abdominoplasty and received intravenous TXA were selected and compared to randomly selected patients who underwent abdominoplasty without administration of TXA. The patient population was divided into two study groups (TXA vs no TXA). Demographic and surgical data as well as complications were evaluated and compared. Appropriate statistical analysis was performed.
Results
Fifty-seven female and 3 male patients with a median age of 38 years and a mean BMI of 25.6 ± 3.3 kg/m
2
were included in the study. Except smoking history, demographic data showed no statistically significant differences between both groups. The most common complication was seroma formation (
n
= 16; 23.9%), and its occurrence was statistically significantly lower in the TXA group (
p
= 0.023). Furthermore, postoperative seroma aspiration was performed in statistically significant lower numbers in the TXA group (
p
< 0.05). No thromboembolic events or seizures were observed.
Discussion
The outcomes of this study showed that the intravenous administration of TXA leads to a significant reduction of seroma formation and postoperative seroma aspiration after abdominoplasty. Simultaneously, no adverse thromboembolic events were detected. Hence we would recommend administration of TXA in body contouring surgery to decrease the incidence of seroma formation.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><identifier>ISSN: 0364-216X</identifier><identifier>ISSN: 1432-5241</identifier><identifier>EISSN: 1432-5241</identifier><identifier>DOI: 10.1007/s00266-024-04094-y</identifier><identifier>PMID: 38750226</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Abdominoplasty - adverse effects ; Abdominoplasty - methods ; Adult ; Antifibrinolytic agents ; Antifibrinolytic Agents - administration & dosage ; Antifibrinolytic Agents - therapeutic use ; Body Contouring - adverse effects ; Body Contouring - methods ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Otorhinolaryngology ; Patients ; Plastic Surgery ; Postoperative Complications - epidemiology ; Postoperative Complications - prevention & control ; Retrospective Studies ; Risk Assessment ; Seroma - epidemiology ; Seroma - etiology ; Seroma - prevention & control ; Thromboembolism ; Tranexamic Acid - administration & dosage ; Tranexamic Acid - therapeutic use ; Treatment Outcome</subject><ispartof>Aesthetic plastic surgery, 2024-08, Vol.48 (15), p.2872-2878</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-77001b54fb0d895731a20de9352385bc4337f311a58f7cabfb81baf86bccffe33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00266-024-04094-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00266-024-04094-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38750226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zaussinger, Maximilian</creatorcontrib><creatorcontrib>Kerschbaumer, Celina</creatorcontrib><creatorcontrib>Schwartz, Bernhard</creatorcontrib><creatorcontrib>Bachleitner, Kathrin</creatorcontrib><creatorcontrib>Ehebruster, Gudrun</creatorcontrib><creatorcontrib>Schmidt, Manfred</creatorcontrib><title>Influence of Tranexamic Acid in Body Contouring Surgery: Significant Changes on Complication Rates after Abdominoplasty</title><title>Aesthetic plastic surgery</title><addtitle>Aesth Plast Surg</addtitle><addtitle>Aesthetic Plast Surg</addtitle><description>Background
Complications after abdominoplasty remain an unsolved issue in body contouring surgery. The antifibrinolytic drug tranexamic acid (TXA) has gained increasing recognition as a valuable pharmacologic agent within plastic surgery. The aim of this study was to investigate the influence of intravenously administered TXA on complications and patient safety after abdominoplasty.
Methods
Within this retrospective single-center study, patients who underwent abdominoplasty and received intravenous TXA were selected and compared to randomly selected patients who underwent abdominoplasty without administration of TXA. The patient population was divided into two study groups (TXA vs no TXA). Demographic and surgical data as well as complications were evaluated and compared. Appropriate statistical analysis was performed.
Results
Fifty-seven female and 3 male patients with a median age of 38 years and a mean BMI of 25.6 ± 3.3 kg/m
2
were included in the study. Except smoking history, demographic data showed no statistically significant differences between both groups. The most common complication was seroma formation (
n
= 16; 23.9%), and its occurrence was statistically significantly lower in the TXA group (
p
= 0.023). Furthermore, postoperative seroma aspiration was performed in statistically significant lower numbers in the TXA group (
p
< 0.05). No thromboembolic events or seizures were observed.
Discussion
The outcomes of this study showed that the intravenous administration of TXA leads to a significant reduction of seroma formation and postoperative seroma aspiration after abdominoplasty. Simultaneously, no adverse thromboembolic events were detected. Hence we would recommend administration of TXA in body contouring surgery to decrease the incidence of seroma formation.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</description><subject>Abdominoplasty - adverse effects</subject><subject>Abdominoplasty - methods</subject><subject>Adult</subject><subject>Antifibrinolytic agents</subject><subject>Antifibrinolytic Agents - administration & dosage</subject><subject>Antifibrinolytic Agents - therapeutic use</subject><subject>Body Contouring - adverse effects</subject><subject>Body Contouring - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Patients</subject><subject>Plastic Surgery</subject><subject>Postoperative Complications - epidemiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Seroma - epidemiology</subject><subject>Seroma - etiology</subject><subject>Seroma - prevention & control</subject><subject>Thromboembolism</subject><subject>Tranexamic Acid - administration & dosage</subject><subject>Tranexamic Acid - therapeutic use</subject><subject>Treatment Outcome</subject><issn>0364-216X</issn><issn>1432-5241</issn><issn>1432-5241</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhoMoznX0D7iQgBs31ZOvpnV3vfgxMCA4I7gLSZpcM7RJTVq0_96Md1Rw4Srk8Jw35-RB6CmBlwRAvioAtG0boLwBDj1vtntoRzijjaCc3Ec7YC1vKGm_nKFHpdwAEColf4jOWCcFUNru0PeL6MfVRetw8vg66-h-6ClYvLdhwCHiN2nY8CHFJa05xCO-WvPR5e01vgrHGHywOi748FXHoys4xYpO81irS6iXT3qpVe0Xl_HeDGkKMc2jLsv2GD3weizuyd15jj6_e3t9-NBcfnx_cdhfNpbRdmmkrEMbwb2BoeuFZERTGFzPBGWdMJYzJj0jRIvOS6uNNx0x2netsdZ7x9g5enHKnXP6trqyqCkU68axLprWohgI0fWcE6jo83_Qm7pzrNNVquuBSdHKStETZXMqJTuv5hwmnTdFQN1qUSctqmpRv7SorTY9u4tezeSGPy2_PVSAnYAy3_6yy3_f_k_sT7uCmag</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Zaussinger, Maximilian</creator><creator>Kerschbaumer, Celina</creator><creator>Schwartz, Bernhard</creator><creator>Bachleitner, Kathrin</creator><creator>Ehebruster, Gudrun</creator><creator>Schmidt, Manfred</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240801</creationdate><title>Influence of Tranexamic Acid in Body Contouring Surgery: Significant Changes on Complication Rates after Abdominoplasty</title><author>Zaussinger, Maximilian ; Kerschbaumer, Celina ; Schwartz, Bernhard ; Bachleitner, Kathrin ; Ehebruster, Gudrun ; Schmidt, Manfred</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-77001b54fb0d895731a20de9352385bc4337f311a58f7cabfb81baf86bccffe33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abdominoplasty - adverse effects</topic><topic>Abdominoplasty - methods</topic><topic>Adult</topic><topic>Antifibrinolytic agents</topic><topic>Antifibrinolytic Agents - administration & dosage</topic><topic>Antifibrinolytic Agents - therapeutic use</topic><topic>Body Contouring - adverse effects</topic><topic>Body Contouring - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Patients</topic><topic>Plastic Surgery</topic><topic>Postoperative Complications - epidemiology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Seroma - epidemiology</topic><topic>Seroma - etiology</topic><topic>Seroma - prevention & control</topic><topic>Thromboembolism</topic><topic>Tranexamic Acid - administration & dosage</topic><topic>Tranexamic Acid - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zaussinger, Maximilian</creatorcontrib><creatorcontrib>Kerschbaumer, Celina</creatorcontrib><creatorcontrib>Schwartz, Bernhard</creatorcontrib><creatorcontrib>Bachleitner, Kathrin</creatorcontrib><creatorcontrib>Ehebruster, Gudrun</creatorcontrib><creatorcontrib>Schmidt, Manfred</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Aesthetic plastic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zaussinger, Maximilian</au><au>Kerschbaumer, Celina</au><au>Schwartz, Bernhard</au><au>Bachleitner, Kathrin</au><au>Ehebruster, Gudrun</au><au>Schmidt, Manfred</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of Tranexamic Acid in Body Contouring Surgery: Significant Changes on Complication Rates after Abdominoplasty</atitle><jtitle>Aesthetic plastic surgery</jtitle><stitle>Aesth Plast Surg</stitle><addtitle>Aesthetic Plast Surg</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>48</volume><issue>15</issue><spage>2872</spage><epage>2878</epage><pages>2872-2878</pages><issn>0364-216X</issn><issn>1432-5241</issn><eissn>1432-5241</eissn><abstract>Background
Complications after abdominoplasty remain an unsolved issue in body contouring surgery. The antifibrinolytic drug tranexamic acid (TXA) has gained increasing recognition as a valuable pharmacologic agent within plastic surgery. The aim of this study was to investigate the influence of intravenously administered TXA on complications and patient safety after abdominoplasty.
Methods
Within this retrospective single-center study, patients who underwent abdominoplasty and received intravenous TXA were selected and compared to randomly selected patients who underwent abdominoplasty without administration of TXA. The patient population was divided into two study groups (TXA vs no TXA). Demographic and surgical data as well as complications were evaluated and compared. Appropriate statistical analysis was performed.
Results
Fifty-seven female and 3 male patients with a median age of 38 years and a mean BMI of 25.6 ± 3.3 kg/m
2
were included in the study. Except smoking history, demographic data showed no statistically significant differences between both groups. The most common complication was seroma formation (
n
= 16; 23.9%), and its occurrence was statistically significantly lower in the TXA group (
p
= 0.023). Furthermore, postoperative seroma aspiration was performed in statistically significant lower numbers in the TXA group (
p
< 0.05). No thromboembolic events or seizures were observed.
Discussion
The outcomes of this study showed that the intravenous administration of TXA leads to a significant reduction of seroma formation and postoperative seroma aspiration after abdominoplasty. Simultaneously, no adverse thromboembolic events were detected. Hence we would recommend administration of TXA in body contouring surgery to decrease the incidence of seroma formation.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors
www.springer.com/00266
.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38750226</pmid><doi>10.1007/s00266-024-04094-y</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Abdominoplasty - adverse effects Abdominoplasty - methods Adult Antifibrinolytic agents Antifibrinolytic Agents - administration & dosage Antifibrinolytic Agents - therapeutic use Body Contouring - adverse effects Body Contouring - methods Female Humans Male Medicine Medicine & Public Health Middle Aged Original Article Otorhinolaryngology Patients Plastic Surgery Postoperative Complications - epidemiology Postoperative Complications - prevention & control Retrospective Studies Risk Assessment Seroma - epidemiology Seroma - etiology Seroma - prevention & control Thromboembolism Tranexamic Acid - administration & dosage Tranexamic Acid - therapeutic use Treatment Outcome |
| title | Influence of Tranexamic Acid in Body Contouring Surgery: Significant Changes on Complication Rates after Abdominoplasty |
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