Enhancing prognostic prediction of invasive candidiasis among cancer patients with a serum C5a-based scoring model
Purpose Invasive candidiasis poses a life-threatening risk, and early prognosis assessment is vital for timely interventions to reduce mortality. Serum C5a levels have recently been linked to prognosis, but confirmation in cancer patients is pending. Methods We detected the concentrations of serum C...
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| Veröffentlicht in: | Supportive care in cancer 2024-06, Vol.32 (6), p.356, Article 356 |
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| creator | Li, Ding Wang, Lin Zhao, Zhihong Bai, Changsen Li, Xichuan |
| description | Purpose
Invasive candidiasis poses a life-threatening risk, and early prognosis assessment is vital for timely interventions to reduce mortality. Serum C5a levels have recently been linked to prognosis, but confirmation in cancer patients is pending.
Methods
We detected the concentrations of serum C5a in hospitalized cancer patients with invasive candidiasis from 2020 to 2023, and retrospectively analyzed the clinical data.
Results
372 cases were included in this study, with a 90-day mortality rate of 21.8%.
Candida albicans
(48.7%) remained the predominant pathogen, followed by
Candida glabrata
(25.5%),
Candida tropicalis
(12.4%), and
Candida parapsilosis
(8.3%). Gastrointestinal cancer was the most diagnosed pathology type (37.6%). Serum C5a demonstrated a noteworthy correlation with 90-day mortality, and employing a cutoff value of 36.7 ng/ml revealed significantly higher 90-day mortality in low-C5a patients (41.2%) compared to high-C5a patients (6.3%) (
p
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| doi_str_mv | 10.1007/s00520-024-08567-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3055894252</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3055237851</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-ff3473faaa6ddb44c475eaeff735d41cfc884ceaa38f97a2a3d4aed3bf62290b3</originalsourceid><addsrcrecordid>eNp9kctuFDEQRS0EIpPHD7BAltiwMXG77Hb3Eo3CQ4rEJqytaj8SR9P2YHcH5e_xZAJILFjZLp17q8qXkDcd_9Bxri8r50pwxoVkfFC9ZvCCbDoJwDTA-JJs-Cg7JkGpE3Ja6z3nndZKvCYnMGjFYew3pFylO0w2plu6L_k25bpE267eRbvEnGgONKYHrPHBU4vJRRfbo1Kcc9O0ivWF7nGJPi2V_ozLHUVafVlnulXIJqze0WpzObSYs_O7c_Iq4K76i-fzjHz_dHWz_cKuv33-uv14zSyIfmEhgNQQELF3bpLSSq08-hA0KCc7G-wwSOsRYQijRoHgJHoHU-iFGPkEZ-T90bct9mP1dTFzrNbvdph8XqsBrtQwSqFEQ9_9g97ntaQ23RMlQA-qa5Q4UrbkWosPZl_ijOXRdNwcEjHHRExLxDwlYqCJ3j5br9Ps3R_J7wgaAEeg7g9_5Mvf3v-x_QX84pi6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3055237851</pqid></control><display><type>article</type><title>Enhancing prognostic prediction of invasive candidiasis among cancer patients with a serum C5a-based scoring model</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Li, Ding ; Wang, Lin ; Zhao, Zhihong ; Bai, Changsen ; Li, Xichuan</creator><creatorcontrib>Li, Ding ; Wang, Lin ; Zhao, Zhihong ; Bai, Changsen ; Li, Xichuan</creatorcontrib><description>Purpose
Invasive candidiasis poses a life-threatening risk, and early prognosis assessment is vital for timely interventions to reduce mortality. Serum C5a levels have recently been linked to prognosis, but confirmation in cancer patients is pending.
Methods
We detected the concentrations of serum C5a in hospitalized cancer patients with invasive candidiasis from 2020 to 2023, and retrospectively analyzed the clinical data.
Results
372 cases were included in this study, with a 90-day mortality rate of 21.8%.
Candida albicans
(48.7%) remained the predominant pathogen, followed by
Candida glabrata
(25.5%),
Candida tropicalis
(12.4%), and
Candida parapsilosis
(8.3%). Gastrointestinal cancer was the most diagnosed pathology type (37.6%). Serum C5a demonstrated a noteworthy correlation with 90-day mortality, and employing a cutoff value of 36.7 ng/ml revealed significantly higher 90-day mortality in low-C5a patients (41.2%) compared to high-C5a patients (6.3%) (
p
< 0.001). We also identified no source control, no surgery, metastasis, or chronic renal failure independently correlated with the 90-day mortality. Based on this, a prognostic model combining C5a and clinical parameters was constructed, which performed better than models built solely on C5a or clinical parameters. Furthermore, we weighted scores to each parameter in the model and presented diagnostic sensitivity and specificity corresponding to different score points calculated by the model.
Conclusion
We constructed a prognostic scoring model including serum C5a and clinical parameters, which would contribute to precise prognosis assessment and benefit the outcome among cancer patients.</description><identifier>ISSN: 0941-4355</identifier><identifier>ISSN: 1433-7339</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-024-08567-3</identifier><identifier>PMID: 38750396</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cancer ; Candidiasis, Invasive - diagnosis ; Candidiasis, Invasive - mortality ; Complement C5a - analysis ; Female ; Fungal infections ; Humans ; Male ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Mortality ; Neoplasms - complications ; Nursing ; Nursing Research ; Oncology ; Pain Medicine ; Prognosis ; Rehabilitation Medicine ; Retrospective Studies</subject><ispartof>Supportive care in cancer, 2024-06, Vol.32 (6), p.356, Article 356</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-ff3473faaa6ddb44c475eaeff735d41cfc884ceaa38f97a2a3d4aed3bf62290b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-024-08567-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-024-08567-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38750396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Ding</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Zhao, Zhihong</creatorcontrib><creatorcontrib>Bai, Changsen</creatorcontrib><creatorcontrib>Li, Xichuan</creatorcontrib><title>Enhancing prognostic prediction of invasive candidiasis among cancer patients with a serum C5a-based scoring model</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Invasive candidiasis poses a life-threatening risk, and early prognosis assessment is vital for timely interventions to reduce mortality. Serum C5a levels have recently been linked to prognosis, but confirmation in cancer patients is pending.
Methods
We detected the concentrations of serum C5a in hospitalized cancer patients with invasive candidiasis from 2020 to 2023, and retrospectively analyzed the clinical data.
Results
372 cases were included in this study, with a 90-day mortality rate of 21.8%.
Candida albicans
(48.7%) remained the predominant pathogen, followed by
Candida glabrata
(25.5%),
Candida tropicalis
(12.4%), and
Candida parapsilosis
(8.3%). Gastrointestinal cancer was the most diagnosed pathology type (37.6%). Serum C5a demonstrated a noteworthy correlation with 90-day mortality, and employing a cutoff value of 36.7 ng/ml revealed significantly higher 90-day mortality in low-C5a patients (41.2%) compared to high-C5a patients (6.3%) (
p
< 0.001). We also identified no source control, no surgery, metastasis, or chronic renal failure independently correlated with the 90-day mortality. Based on this, a prognostic model combining C5a and clinical parameters was constructed, which performed better than models built solely on C5a or clinical parameters. Furthermore, we weighted scores to each parameter in the model and presented diagnostic sensitivity and specificity corresponding to different score points calculated by the model.
Conclusion
We constructed a prognostic scoring model including serum C5a and clinical parameters, which would contribute to precise prognosis assessment and benefit the outcome among cancer patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Candidiasis, Invasive - diagnosis</subject><subject>Candidiasis, Invasive - mortality</subject><subject>Complement C5a - analysis</subject><subject>Female</subject><subject>Fungal infections</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoplasms - complications</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Pain Medicine</subject><subject>Prognosis</subject><subject>Rehabilitation Medicine</subject><subject>Retrospective Studies</subject><issn>0941-4355</issn><issn>1433-7339</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctuFDEQRS0EIpPHD7BAltiwMXG77Hb3Eo3CQ4rEJqytaj8SR9P2YHcH5e_xZAJILFjZLp17q8qXkDcd_9Bxri8r50pwxoVkfFC9ZvCCbDoJwDTA-JJs-Cg7JkGpE3Ja6z3nndZKvCYnMGjFYew3pFylO0w2plu6L_k25bpE267eRbvEnGgONKYHrPHBU4vJRRfbo1Kcc9O0ivWF7nGJPi2V_ozLHUVafVlnulXIJqze0WpzObSYs_O7c_Iq4K76i-fzjHz_dHWz_cKuv33-uv14zSyIfmEhgNQQELF3bpLSSq08-hA0KCc7G-wwSOsRYQijRoHgJHoHU-iFGPkEZ-T90bct9mP1dTFzrNbvdph8XqsBrtQwSqFEQ9_9g97ntaQ23RMlQA-qa5Q4UrbkWosPZl_ijOXRdNwcEjHHRExLxDwlYqCJ3j5br9Ps3R_J7wgaAEeg7g9_5Mvf3v-x_QX84pi6</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Li, Ding</creator><creator>Wang, Lin</creator><creator>Zhao, Zhihong</creator><creator>Bai, Changsen</creator><creator>Li, Xichuan</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20240601</creationdate><title>Enhancing prognostic prediction of invasive candidiasis among cancer patients with a serum C5a-based scoring model</title><author>Li, Ding ; Wang, Lin ; Zhao, Zhihong ; Bai, Changsen ; Li, Xichuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-ff3473faaa6ddb44c475eaeff735d41cfc884ceaa38f97a2a3d4aed3bf62290b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Candidiasis, Invasive - diagnosis</topic><topic>Candidiasis, Invasive - mortality</topic><topic>Complement C5a - analysis</topic><topic>Female</topic><topic>Fungal infections</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoplasms - complications</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Pain Medicine</topic><topic>Prognosis</topic><topic>Rehabilitation Medicine</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Ding</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Zhao, Zhihong</creatorcontrib><creatorcontrib>Bai, Changsen</creatorcontrib><creatorcontrib>Li, Xichuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ding</au><au>Wang, Lin</au><au>Zhao, Zhihong</au><au>Bai, Changsen</au><au>Li, Xichuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhancing prognostic prediction of invasive candidiasis among cancer patients with a serum C5a-based scoring model</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>32</volume><issue>6</issue><spage>356</spage><pages>356-</pages><artnum>356</artnum><issn>0941-4355</issn><issn>1433-7339</issn><eissn>1433-7339</eissn><abstract>Purpose
Invasive candidiasis poses a life-threatening risk, and early prognosis assessment is vital for timely interventions to reduce mortality. Serum C5a levels have recently been linked to prognosis, but confirmation in cancer patients is pending.
Methods
We detected the concentrations of serum C5a in hospitalized cancer patients with invasive candidiasis from 2020 to 2023, and retrospectively analyzed the clinical data.
Results
372 cases were included in this study, with a 90-day mortality rate of 21.8%.
Candida albicans
(48.7%) remained the predominant pathogen, followed by
Candida glabrata
(25.5%),
Candida tropicalis
(12.4%), and
Candida parapsilosis
(8.3%). Gastrointestinal cancer was the most diagnosed pathology type (37.6%). Serum C5a demonstrated a noteworthy correlation with 90-day mortality, and employing a cutoff value of 36.7 ng/ml revealed significantly higher 90-day mortality in low-C5a patients (41.2%) compared to high-C5a patients (6.3%) (
p
< 0.001). We also identified no source control, no surgery, metastasis, or chronic renal failure independently correlated with the 90-day mortality. Based on this, a prognostic model combining C5a and clinical parameters was constructed, which performed better than models built solely on C5a or clinical parameters. Furthermore, we weighted scores to each parameter in the model and presented diagnostic sensitivity and specificity corresponding to different score points calculated by the model.
Conclusion
We constructed a prognostic scoring model including serum C5a and clinical parameters, which would contribute to precise prognosis assessment and benefit the outcome among cancer patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38750396</pmid><doi>10.1007/s00520-024-08567-3</doi></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Cancer Candidiasis, Invasive - diagnosis Candidiasis, Invasive - mortality Complement C5a - analysis Female Fungal infections Humans Male Medical prognosis Medicine Medicine & Public Health Middle Aged Mortality Neoplasms - complications Nursing Nursing Research Oncology Pain Medicine Prognosis Rehabilitation Medicine Retrospective Studies |
| title | Enhancing prognostic prediction of invasive candidiasis among cancer patients with a serum C5a-based scoring model |
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