The ‘in’s and out’s’ of descending pain modulation from the rostral ventromedial medulla

The rostral ventromedial medulla (RVM) is the key output node of the descending pain-modulating system.Intrinsic and extrinsic factors contribute to the pain experience by influencing the activity of two functional types of RVM neurons, OFF-cells and ON-cells, which respectively exert inhibitory and...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2024-06, Vol.47 (6), p.447-460
Hauptverfasser:	De Preter, Caitlynn C., Heinricher, Mary M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals brainstem descending control Humans Medulla Oblongata - physiology Medulla Oblongata - physiopathology Neural Pathways - physiology Neural Pathways - physiopathology Neurons - physiology pain Pain - physiopathology periaqueductal gray population dynamics rostral ventromedial medulla
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