Dose-dependent effects of gamma radiation sterilization on the collagen matrix of human cortical bone allograft and its influence on fatigue crack propagation resistance

Fatigue crack propagation resistance and high-cycle S–N fatigue life of cortical bone allograft tissue are both negatively impacted in a radiation dose-dependent manner from 0 to 25 kGy. The standard radiation sterilization dose of 25–35 kGy has been shown to induce cleavage of collagen molecules in...

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Veröffentlicht in:	Cell and tissue banking 2024-09, Vol.25 (3), p.735-745
Hauptverfasser:	Crocker, Dylan B., Hering, Thomas M., Akkus, Ozan, Oest, Megan E., Rimnac, Clare M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced glycosylation end products Allografts Amino Acids - analysis Amino Acids - metabolism Arginine - analogs & derivatives Biomedical and Life Sciences Biomedicine Bone grafts Bone matrix Bone Transplantation Cell Biology Collagen Collagen - metabolism Cortical bone Cortical Bone - radiation effects Crack propagation Cross-linking Dose-Response Relationship, Radiation Femur - radiation effects Full Length Paper Gamma Rays Glycation End Products, Advanced - metabolism Humans Life Sciences Lysine - analogs & derivatives Lysine - metabolism Materials fatigue Mechanical loading Pentosidine Propagation Pyridinoline Radiation Sterilization Sterilization - methods Transplant Surgery γ Radiation
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