Repurposing simvastatin in cancer treatment: an updated review on pharmacological and nanotechnological aspects

Management of cancer is challenging due to non-targeting and high side effect issues. Drug repurposing is an innovative method for employing medications for other disease therapy in addition to their original use. Simvastatin, a 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor, is a lipid-l...

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Veröffentlicht in:	Naunyn-Schmiedeberg's archives of pharmacology 2024-10, Vol.397 (10), p.7377-7393
Hauptverfasser:	Ara, Nargis, Hafeez, Abdul, Kushwaha, Shom Prakash
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bioavailability Biomedical and Life Sciences Biomedicine Cancer Cancer therapies Cell culture Clinical trials Colon cancer Disease management Drug delivery Drug Repositioning Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage Hydroxymethylglutaryl-CoA Reductase Inhibitors - chemistry Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacokinetics Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Liver cancer Lung cancer Lung carcinoma Medical innovations Microparticles Nanoparticles Nanotechnology Neoplasms - drug therapy Neurosciences Pharmaceuticals Pharmacodynamics Pharmacokinetics Pharmacology/Toxicology Prostate carcinoma Review Simvastatin Simvastatin - administration & dosage Simvastatin - pharmacokinetics Simvastatin - pharmacology Simvastatin - therapeutic use Solubility
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