Uncovering the Role of Methylmercury on DNA Lesions at Cytotoxic Concentrations in Glutathione-Depleted Cells: Insights from Experimental and Computational Studies

Organomercurials (RHg+), especially methylmercury (MeHg+) and ethylmercury (EtHg+), are considered to be more neurotoxic than the inorganic counterpart (Hg2+). They cause massive DNA damage in cells, especially in neurons, where cellular glutathione (GSH) levels are significantly low. However, the m...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Inorganic chemistry 2024-06, Vol.63 (23), p.10455-10465
Hauptverfasser:	Das, Ranajit, Karri, Ramesh, Chalana, Ashish, Rai, Rakesh Kumar, Roy, Gouriprasanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Survival - drug effects Density Functional Theory DNA - chemistry DNA - drug effects DNA Damage - drug effects Glutathione - chemistry Glutathione - metabolism Humans Methylmercury Compounds - chemistry Methylmercury Compounds - pharmacology Molecular Structure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!