Hollow versatile Ag@Pt alloy nanoparticles with nanozyme activity for detection and photothermal sterilization of Helicobacter pylori
In view of a large number of people infected with Helicobacter pylori ( H. pylori ) with great harm followed, there is an urgent need to develop a non-invasive, easy-to-operate, and rapid detection method, and to identify effective sterilization strategies. In this study, highly specific nanoprobes...
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| Veröffentlicht in: | Mikrochimica acta (1966) 2024-06, Vol.191 (6), p.330-330, Article 330 |
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| creator | Zhang, Leheng Ji, Li Lin, Mingxia Liu, Ruizhuo Yang, Huiyi Zhao, Jingjing Zhao, Suqing |
| description | In view of a large number of people infected with
Helicobacter pylori
(
H. pylori
) with great harm followed, there is an urgent need to develop a non-invasive, easy-to-operate, and rapid detection method, and to identify effective sterilization strategies. In this study, highly specific nanoprobes with nanozyme activity, Ag@Pt nanoparticles (NPs) with the antibody, were utilized as a novel lateral flow immunoassay (LFIA). The optical label (Ag@Pt NPs) was enhanced by the introduction of the chromogenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB) and compared with a gold nanoparticles (Au NPs) optical label. Under the optimal condition, Ag@Pt-LFIA and TMB-enhanced Ag@Pt-LFIA for
H. pylori
were successfully established, two of which were over twofold and 100-fold more sensitive than conventional visual Au NP-based LFIA, respectively. Furthermore, Ag@Pt NPs with the antibody irradiated with NIR laser (808 nm) at a power intensity of 550 mW/cm
2
for 5 min exhibited a remarkable antibacterial effect. The nanoprobes could close to bacteria through effective interactions between antibodies and bacteria, thereby benefiting photothermal sterilization. Overall, Ag@Pt NPs provide promising applications in pathogen detection and therapeutic applications.
Graphical Abstract |
| doi_str_mv | 10.1007/s00604-024-06304-5 |
| format | Article |
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Helicobacter pylori
(
H. pylori
) with great harm followed, there is an urgent need to develop a non-invasive, easy-to-operate, and rapid detection method, and to identify effective sterilization strategies. In this study, highly specific nanoprobes with nanozyme activity, Ag@Pt nanoparticles (NPs) with the antibody, were utilized as a novel lateral flow immunoassay (LFIA). The optical label (Ag@Pt NPs) was enhanced by the introduction of the chromogenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB) and compared with a gold nanoparticles (Au NPs) optical label. Under the optimal condition, Ag@Pt-LFIA and TMB-enhanced Ag@Pt-LFIA for
H. pylori
were successfully established, two of which were over twofold and 100-fold more sensitive than conventional visual Au NP-based LFIA, respectively. Furthermore, Ag@Pt NPs with the antibody irradiated with NIR laser (808 nm) at a power intensity of 550 mW/cm
2
for 5 min exhibited a remarkable antibacterial effect. The nanoprobes could close to bacteria through effective interactions between antibodies and bacteria, thereby benefiting photothermal sterilization. Overall, Ag@Pt NPs provide promising applications in pathogen detection and therapeutic applications.
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Helicobacter pylori
(
H. pylori
) with great harm followed, there is an urgent need to develop a non-invasive, easy-to-operate, and rapid detection method, and to identify effective sterilization strategies. In this study, highly specific nanoprobes with nanozyme activity, Ag@Pt nanoparticles (NPs) with the antibody, were utilized as a novel lateral flow immunoassay (LFIA). The optical label (Ag@Pt NPs) was enhanced by the introduction of the chromogenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB) and compared with a gold nanoparticles (Au NPs) optical label. Under the optimal condition, Ag@Pt-LFIA and TMB-enhanced Ag@Pt-LFIA for
H. pylori
were successfully established, two of which were over twofold and 100-fold more sensitive than conventional visual Au NP-based LFIA, respectively. Furthermore, Ag@Pt NPs with the antibody irradiated with NIR laser (808 nm) at a power intensity of 550 mW/cm
2
for 5 min exhibited a remarkable antibacterial effect. The nanoprobes could close to bacteria through effective interactions between antibodies and bacteria, thereby benefiting photothermal sterilization. Overall, Ag@Pt NPs provide promising applications in pathogen detection and therapeutic applications.
Graphical Abstract</description><subject>Alloys - chemistry</subject><subject>Analytical Chemistry</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibodies</subject><subject>Bacteria</subject><subject>Benzidines - chemistry</subject><subject>Characterization and Evaluation of Materials</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Gold</subject><subject>Gold - chemistry</subject><subject>Helicobacter pylori - drug effects</subject><subject>Helicobacter pylori - radiation effects</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunoassay - methods</subject><subject>Labels</subject><subject>Limit of Detection</subject><subject>Metal Nanoparticles - chemistry</subject><subject>Microengineering</subject><subject>Nanoalloys</subject><subject>Nanochemistry</subject><subject>Nanoparticles</subject><subject>Nanotechnology</subject><subject>Original Paper</subject><subject>Platinum</subject><subject>Platinum - chemistry</subject><subject>Platinum base alloys</subject><subject>Silver</subject><subject>Silver - chemistry</subject><subject>Sterilization</subject><subject>Sterilization - methods</subject><subject>Substrates</subject><issn>0026-3672</issn><issn>1436-5073</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxS0EotvCF-CALHHhEhj_371RVdBFqgQHOEeOM-m6cuJge1uld7437m4BiQMHa-yZ33se6RHyisE7BmDeZwANsgFejxb1pp6QFZNCNwqMeEpWAFw3Qht-Qk5zvgFgRnP5nJyItZHSiPWK_NzGEOIdvcWUbfEB6fn1h6-F2tpd6GSnONtUvAuY6Z0vu0PrfhmRWlf8rS8LHWKiPRas7zhRO_V03sUSyw7TaAPNBZMP_t4exnGgWwzexa7qMdF5CTH5F-TZYEPGl4_1jHz_9PHbxba5-nL5-eL8qnHCqNI4A2oQmgsFyHtAx3nvOHYDUx0XFs2AG80YdsLJtQMtLdNKceSuN0obLc7I26PvnOKPPebSjj47DMFOGPe5FaCUVCAFVPTNP-hN3KepbvdAyY3eCLWuFD9SLsWcEw7tnPxo09IyaB9Cao8htTWk9hBSq6ro9aP1vhux_yP5nUoFxBHIdTRdY_r7939sfwF50p9V</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Zhang, Leheng</creator><creator>Ji, Li</creator><creator>Lin, Mingxia</creator><creator>Liu, Ruizhuo</creator><creator>Yang, Huiyi</creator><creator>Zhao, Jingjing</creator><creator>Zhao, Suqing</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8458-671X</orcidid></search><sort><creationdate>20240601</creationdate><title>Hollow versatile Ag@Pt alloy nanoparticles with nanozyme activity for detection and photothermal sterilization of Helicobacter pylori</title><author>Zhang, Leheng ; Ji, Li ; Lin, Mingxia ; Liu, Ruizhuo ; Yang, Huiyi ; Zhao, Jingjing ; Zhao, Suqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-c705f362350e2d0ec22dc2ebf15b23ae7fe9611eb3c48c064a16552e2cd756763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Alloys - chemistry</topic><topic>Analytical Chemistry</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibodies</topic><topic>Bacteria</topic><topic>Benzidines - chemistry</topic><topic>Characterization and Evaluation of Materials</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Gold</topic><topic>Gold - chemistry</topic><topic>Helicobacter pylori - drug effects</topic><topic>Helicobacter pylori - radiation effects</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunoassay - methods</topic><topic>Labels</topic><topic>Limit of Detection</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Microengineering</topic><topic>Nanoalloys</topic><topic>Nanochemistry</topic><topic>Nanoparticles</topic><topic>Nanotechnology</topic><topic>Original Paper</topic><topic>Platinum</topic><topic>Platinum - chemistry</topic><topic>Platinum base alloys</topic><topic>Silver</topic><topic>Silver - chemistry</topic><topic>Sterilization</topic><topic>Sterilization - methods</topic><topic>Substrates</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Leheng</creatorcontrib><creatorcontrib>Ji, Li</creatorcontrib><creatorcontrib>Lin, Mingxia</creatorcontrib><creatorcontrib>Liu, Ruizhuo</creatorcontrib><creatorcontrib>Yang, Huiyi</creatorcontrib><creatorcontrib>Zhao, Jingjing</creatorcontrib><creatorcontrib>Zhao, Suqing</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Mikrochimica acta (1966)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Leheng</au><au>Ji, Li</au><au>Lin, Mingxia</au><au>Liu, Ruizhuo</au><au>Yang, Huiyi</au><au>Zhao, Jingjing</au><au>Zhao, Suqing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hollow versatile Ag@Pt alloy nanoparticles with nanozyme activity for detection and photothermal sterilization of Helicobacter pylori</atitle><jtitle>Mikrochimica acta (1966)</jtitle><stitle>Microchim Acta</stitle><addtitle>Mikrochim Acta</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>191</volume><issue>6</issue><spage>330</spage><epage>330</epage><pages>330-330</pages><artnum>330</artnum><issn>0026-3672</issn><eissn>1436-5073</eissn><abstract>In view of a large number of people infected with
Helicobacter pylori
(
H. pylori
) with great harm followed, there is an urgent need to develop a non-invasive, easy-to-operate, and rapid detection method, and to identify effective sterilization strategies. In this study, highly specific nanoprobes with nanozyme activity, Ag@Pt nanoparticles (NPs) with the antibody, were utilized as a novel lateral flow immunoassay (LFIA). The optical label (Ag@Pt NPs) was enhanced by the introduction of the chromogenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB) and compared with a gold nanoparticles (Au NPs) optical label. Under the optimal condition, Ag@Pt-LFIA and TMB-enhanced Ag@Pt-LFIA for
H. pylori
were successfully established, two of which were over twofold and 100-fold more sensitive than conventional visual Au NP-based LFIA, respectively. Furthermore, Ag@Pt NPs with the antibody irradiated with NIR laser (808 nm) at a power intensity of 550 mW/cm
2
for 5 min exhibited a remarkable antibacterial effect. The nanoprobes could close to bacteria through effective interactions between antibodies and bacteria, thereby benefiting photothermal sterilization. Overall, Ag@Pt NPs provide promising applications in pathogen detection and therapeutic applications.
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| ispartof | Mikrochimica acta (1966), 2024-06, Vol.191 (6), p.330-330, Article 330 |
| issn | 0026-3672 1436-5073 |
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| subjects | Alloys - chemistry Analytical Chemistry Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibodies Bacteria Benzidines - chemistry Characterization and Evaluation of Materials Chemistry Chemistry and Materials Science Gold Gold - chemistry Helicobacter pylori - drug effects Helicobacter pylori - radiation effects Humans Immunoassay Immunoassay - methods Labels Limit of Detection Metal Nanoparticles - chemistry Microengineering Nanoalloys Nanochemistry Nanoparticles Nanotechnology Original Paper Platinum Platinum - chemistry Platinum base alloys Silver Silver - chemistry Sterilization Sterilization - methods Substrates |
| title | Hollow versatile Ag@Pt alloy nanoparticles with nanozyme activity for detection and photothermal sterilization of Helicobacter pylori |
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