Advances in hyaluronic acid production: Biosynthesis and genetic engineering strategies based on Streptococcus — A review
Hyaluronic acid (HA), which is a highly versatile glycosaminoglycan, is widely applied across the fields of food, cosmetics, and pharmaceuticals. It is primary produced through Streptococcus fermentation, but the product presents inherent challenges concerning consistency and potential pathogenicity...
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| Veröffentlicht in: | International journal of biological macromolecules 2024-06, Vol.270 (Pt 2), p.132334-132334, Article 132334 |
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| container_end_page | 132334 |
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| container_issue | Pt 2 |
| container_start_page | 132334 |
| container_title | International journal of biological macromolecules |
| container_volume | 270 |
| creator | Wei, Mengmeng Huang, Ying Zhu, Junyuan Qiao, Yufan Xiao, Na Jin, Mengying Gao, Han Huang, Yitie Hu, Xiufang Li, Ou |
| description | Hyaluronic acid (HA), which is a highly versatile glycosaminoglycan, is widely applied across the fields of food, cosmetics, and pharmaceuticals. It is primary produced through Streptococcus fermentation, but the product presents inherent challenges concerning consistency and potential pathogenicity. However, recent strides in molecular biology have paved the way for genetic engineering, which facilitates the creation of high-yield, nonpathogenic strains adept at synthesizing HA with specific molecular weights. This comprehensive review extensively explores the molecular biology underpinning pivotal HA synthase genes, which elucidates the intricate mechanisms governing HA synthesis. Moreover, it delineates various strategies employed in engineering HA-producing strains.
•Defects in commercial microbial fermentation to produce hyaluronic acid.•Gene-edited microbes produce high-quality hyaluronic acid.•Key genes control hyaluronic acid production and molecular weight.•Bioproduction of hyaluronic acid driven by synthetic biology. |
| doi_str_mv | 10.1016/j.ijbiomac.2024.132334 |
| format | Article |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | Biosynthesis pathway Genetic engineering Hyaluronic acid |
| title | Advances in hyaluronic acid production: Biosynthesis and genetic engineering strategies based on Streptococcus — A review |
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