Porcine nasal septum cartilage-derived decellularized matrix promotes chondrogenic differentiation of human umbilical mesenchymal stem cells without exogenous growth factors
Background: In the domain of plastic surgery, nasal cartilage regeneration is of significant importance. The extracellular matrix (ECM) from porcine nasal septum cartilage has shown potential for promoting human cartilage regeneration. Nonetheless, the specific biological inductive factors and their...
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| creator | Shen, Jinpeng Ye, Danyan Jin, Hao Wu, Yongxuan Peng, Lihong Liang, Yan |
| description | Background: In the domain of plastic surgery, nasal cartilage regeneration is of significant importance. The extracellular matrix (ECM) from porcine nasal septum cartilage has shown potential for promoting human cartilage regeneration. Nonetheless, the specific biological inductive factors and their pathways in cartilage tissue engineering remain undefined. Methods: The decellularized matrix derived from porcine nasal septum cartilage (PN-DCM) was prepared using a grinding method. Human umbilical cord mesenchymal stem cells (HuMSCs) were cultured on these PN-DCM scaffolds for 4 weeks without exogenous growth factors to evaluate their chondroinductive potential. Subsequently, proteomic analysis was employed to identify potential biological inductive factors within the PN-DCM scaffolds. Results: Compared to the TGF-β3-cultured pellet model serving as a positive control, the PN-DCM scaffolds promoted significant deposition of a Safranin-O positive matrix and Type II collagen by HuMSCs. Gene expression profiling revealed upregulation of ACAN, COL2A1, and SOX9. Proteomic analysis identified potential chondroinductive factors in the PN-DCM scaffolds, including CYTL1, CTGF, MGP, ITGB1, BMP7, and GDF5, which influence HuMSC differentiation. Conclusion: Our findings have demonstrated that the PN-DCM scaffolds promoted HuMSC differentiation towards a nasal chondrocyte phenotype without the supplementation of exogenous growth factors. This outcome is associated with the chondroinductive factors present within the PN-DCM scaffolds.
The PN-DCM scaffolds, derived from porcine nasal septum cartilage by cryo-grinding, induce HuMSCs to become chondrocyte-like without external growth factors. Proteomics showed that PN-DCM's capability relies on preserving specific components. |
| doi_str_mv | 10.1039/d3tb03077f |
| format | Article |
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The PN-DCM scaffolds, derived from porcine nasal septum cartilage by cryo-grinding, induce HuMSCs to become chondrocyte-like without external growth factors. Proteomics showed that PN-DCM's capability relies on preserving specific components.</description><identifier>ISSN: 2050-750X</identifier><identifier>EISSN: 2050-7518</identifier><identifier>DOI: 10.1039/d3tb03077f</identifier><identifier>PMID: 38745541</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Animals ; Cartilage ; Cell Differentiation ; Cells, Cultured ; Chondrocytes ; Chondrogenesis ; Collagen (type II) ; Connective tissue growth factor ; Decellularized Extracellular Matrix - chemistry ; Decellularized Extracellular Matrix - pharmacology ; Differentiation ; Extracellular matrix ; Extracellular Matrix - chemistry ; Extracellular Matrix - metabolism ; Gene expression ; Growth differentiation factor 5 ; Growth factors ; Humans ; Mesenchymal stem cells ; Mesenchymal Stem Cells - cytology ; Mesenchymal Stem Cells - metabolism ; Nasal Septum - chemistry ; Nasal Septum - cytology ; Phenotypes ; Plastic surgery ; Proteomics ; Regeneration ; Safranin-O ; Scaffolds ; Septum ; Sox9 protein ; Stem cells ; Swine ; Tissue Engineering ; Tissue Scaffolds - chemistry ; Umbilical cord ; Umbilical Cord - cytology</subject><ispartof>Journal of materials chemistry. B, Materials for biology and medicine, 2024-06, Vol.12 (22), p.5513-5524</ispartof><rights>Copyright Royal Society of Chemistry 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c296t-69a9e2a29c13f4a499df1c041a8cb94478ce9ae352871219b4a462adbdf14913</cites><orcidid>0000-0002-1847-1703 ; 0009-0007-7957-2122 ; 0000-0002-4165-046X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38745541$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shen, Jinpeng</creatorcontrib><creatorcontrib>Ye, Danyan</creatorcontrib><creatorcontrib>Jin, Hao</creatorcontrib><creatorcontrib>Wu, Yongxuan</creatorcontrib><creatorcontrib>Peng, Lihong</creatorcontrib><creatorcontrib>Liang, Yan</creatorcontrib><title>Porcine nasal septum cartilage-derived decellularized matrix promotes chondrogenic differentiation of human umbilical mesenchymal stem cells without exogenous growth factors</title><title>Journal of materials chemistry. B, Materials for biology and medicine</title><addtitle>J Mater Chem B</addtitle><description>Background: In the domain of plastic surgery, nasal cartilage regeneration is of significant importance. The extracellular matrix (ECM) from porcine nasal septum cartilage has shown potential for promoting human cartilage regeneration. Nonetheless, the specific biological inductive factors and their pathways in cartilage tissue engineering remain undefined. Methods: The decellularized matrix derived from porcine nasal septum cartilage (PN-DCM) was prepared using a grinding method. Human umbilical cord mesenchymal stem cells (HuMSCs) were cultured on these PN-DCM scaffolds for 4 weeks without exogenous growth factors to evaluate their chondroinductive potential. Subsequently, proteomic analysis was employed to identify potential biological inductive factors within the PN-DCM scaffolds. Results: Compared to the TGF-β3-cultured pellet model serving as a positive control, the PN-DCM scaffolds promoted significant deposition of a Safranin-O positive matrix and Type II collagen by HuMSCs. Gene expression profiling revealed upregulation of ACAN, COL2A1, and SOX9. Proteomic analysis identified potential chondroinductive factors in the PN-DCM scaffolds, including CYTL1, CTGF, MGP, ITGB1, BMP7, and GDF5, which influence HuMSC differentiation. Conclusion: Our findings have demonstrated that the PN-DCM scaffolds promoted HuMSC differentiation towards a nasal chondrocyte phenotype without the supplementation of exogenous growth factors. This outcome is associated with the chondroinductive factors present within the PN-DCM scaffolds.
The PN-DCM scaffolds, derived from porcine nasal septum cartilage by cryo-grinding, induce HuMSCs to become chondrocyte-like without external growth factors. Proteomics showed that PN-DCM's capability relies on preserving specific components.</description><subject>Animals</subject><subject>Cartilage</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Chondrocytes</subject><subject>Chondrogenesis</subject><subject>Collagen (type II)</subject><subject>Connective tissue growth factor</subject><subject>Decellularized Extracellular Matrix - chemistry</subject><subject>Decellularized Extracellular Matrix - pharmacology</subject><subject>Differentiation</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix - chemistry</subject><subject>Extracellular Matrix - metabolism</subject><subject>Gene expression</subject><subject>Growth differentiation factor 5</subject><subject>Growth factors</subject><subject>Humans</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchymal Stem Cells - cytology</subject><subject>Mesenchymal Stem Cells - metabolism</subject><subject>Nasal Septum - chemistry</subject><subject>Nasal Septum - cytology</subject><subject>Phenotypes</subject><subject>Plastic surgery</subject><subject>Proteomics</subject><subject>Regeneration</subject><subject>Safranin-O</subject><subject>Scaffolds</subject><subject>Septum</subject><subject>Sox9 protein</subject><subject>Stem cells</subject><subject>Swine</subject><subject>Tissue Engineering</subject><subject>Tissue Scaffolds - chemistry</subject><subject>Umbilical cord</subject><subject>Umbilical Cord - cytology</subject><issn>2050-750X</issn><issn>2050-7518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdks9vFCEcxSdGY5vai3cNiRdjMgoDMwNHrVZNmuhhD94mDHzZoRlg5Ydt_Z_8H2XduiZyAcIn7z14NM1Tgl8TTMUbTfOMKR5H86A57XCP27En_OFxjb-dNOcpXeM6OBk4ZY-bE8pH1veMnDa_voaorAfkZZIrSrDLxSElY7ar3EKrIdofoJEGBetaVhntz7p1Mkd7i3YxuJAhIbUEr2PYgrcKaWsMRPDZymyDR8GgpTjpUXGzXa2qPg4SeLXcub1nhupY1RO6sXkJJSO43UuFktA2hpu8ICNVDjE9aR4ZuSY4v5_Pms3lh83Fp_bqy8fPF2-vWtWJIbeDkAI62QlFqGGSCaENUZgRydUsGBu5AiGB9h0fSUfEXJmhk3quGBOEnjUvD7L1ft8LpDw5m_YJpYcaaqK4Ph7jomcVffEfeh1K9DVcpQY2UI57XqlXB0rFkFIEM-2idTLeTQRP-xqn93Tz7k-NlxV-fi9ZZgf6iP4trQLPDkBM6nj67x_Q31iZptw</recordid><startdate>20240605</startdate><enddate>20240605</enddate><creator>Shen, Jinpeng</creator><creator>Ye, Danyan</creator><creator>Jin, Hao</creator><creator>Wu, Yongxuan</creator><creator>Peng, Lihong</creator><creator>Liang, Yan</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QF</scope><scope>7QO</scope><scope>7QQ</scope><scope>7SC</scope><scope>7SE</scope><scope>7SP</scope><scope>7SR</scope><scope>7TA</scope><scope>7TB</scope><scope>7U5</scope><scope>8BQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>H8D</scope><scope>H8G</scope><scope>JG9</scope><scope>JQ2</scope><scope>KR7</scope><scope>L7M</scope><scope>L~C</scope><scope>L~D</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1847-1703</orcidid><orcidid>https://orcid.org/0009-0007-7957-2122</orcidid><orcidid>https://orcid.org/0000-0002-4165-046X</orcidid></search><sort><creationdate>20240605</creationdate><title>Porcine nasal septum cartilage-derived decellularized matrix promotes chondrogenic differentiation of human umbilical mesenchymal stem cells without exogenous growth factors</title><author>Shen, Jinpeng ; Ye, Danyan ; Jin, Hao ; Wu, Yongxuan ; Peng, Lihong ; Liang, Yan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c296t-69a9e2a29c13f4a499df1c041a8cb94478ce9ae352871219b4a462adbdf14913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Cartilage</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>Chondrocytes</topic><topic>Chondrogenesis</topic><topic>Collagen (type II)</topic><topic>Connective tissue growth factor</topic><topic>Decellularized Extracellular Matrix - chemistry</topic><topic>Decellularized Extracellular Matrix - pharmacology</topic><topic>Differentiation</topic><topic>Extracellular matrix</topic><topic>Extracellular Matrix - chemistry</topic><topic>Extracellular Matrix - metabolism</topic><topic>Gene expression</topic><topic>Growth differentiation factor 5</topic><topic>Growth factors</topic><topic>Humans</topic><topic>Mesenchymal stem cells</topic><topic>Mesenchymal Stem Cells - cytology</topic><topic>Mesenchymal Stem Cells - metabolism</topic><topic>Nasal Septum - chemistry</topic><topic>Nasal Septum - cytology</topic><topic>Phenotypes</topic><topic>Plastic surgery</topic><topic>Proteomics</topic><topic>Regeneration</topic><topic>Safranin-O</topic><topic>Scaffolds</topic><topic>Septum</topic><topic>Sox9 protein</topic><topic>Stem cells</topic><topic>Swine</topic><topic>Tissue Engineering</topic><topic>Tissue Scaffolds - chemistry</topic><topic>Umbilical cord</topic><topic>Umbilical Cord - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shen, Jinpeng</creatorcontrib><creatorcontrib>Ye, Danyan</creatorcontrib><creatorcontrib>Jin, Hao</creatorcontrib><creatorcontrib>Wu, Yongxuan</creatorcontrib><creatorcontrib>Peng, Lihong</creatorcontrib><creatorcontrib>Liang, Yan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Aluminium Industry Abstracts</collection><collection>Biotechnology Research Abstracts</collection><collection>Ceramic Abstracts</collection><collection>Computer and Information Systems Abstracts</collection><collection>Corrosion Abstracts</collection><collection>Electronics & Communications Abstracts</collection><collection>Engineered Materials Abstracts</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Aerospace Database</collection><collection>Copper Technical Reference Library</collection><collection>Materials Research Database</collection><collection>ProQuest Computer Science Collection</collection><collection>Civil Engineering Abstracts</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Computer and Information Systems Abstracts Academic</collection><collection>Computer and Information Systems Abstracts Professional</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shen, Jinpeng</au><au>Ye, Danyan</au><au>Jin, Hao</au><au>Wu, Yongxuan</au><au>Peng, Lihong</au><au>Liang, Yan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Porcine nasal septum cartilage-derived decellularized matrix promotes chondrogenic differentiation of human umbilical mesenchymal stem cells without exogenous growth factors</atitle><jtitle>Journal of materials chemistry. B, Materials for biology and medicine</jtitle><addtitle>J Mater Chem B</addtitle><date>2024-06-05</date><risdate>2024</risdate><volume>12</volume><issue>22</issue><spage>5513</spage><epage>5524</epage><pages>5513-5524</pages><issn>2050-750X</issn><eissn>2050-7518</eissn><abstract>Background: In the domain of plastic surgery, nasal cartilage regeneration is of significant importance. The extracellular matrix (ECM) from porcine nasal septum cartilage has shown potential for promoting human cartilage regeneration. Nonetheless, the specific biological inductive factors and their pathways in cartilage tissue engineering remain undefined. Methods: The decellularized matrix derived from porcine nasal septum cartilage (PN-DCM) was prepared using a grinding method. Human umbilical cord mesenchymal stem cells (HuMSCs) were cultured on these PN-DCM scaffolds for 4 weeks without exogenous growth factors to evaluate their chondroinductive potential. Subsequently, proteomic analysis was employed to identify potential biological inductive factors within the PN-DCM scaffolds. Results: Compared to the TGF-β3-cultured pellet model serving as a positive control, the PN-DCM scaffolds promoted significant deposition of a Safranin-O positive matrix and Type II collagen by HuMSCs. Gene expression profiling revealed upregulation of ACAN, COL2A1, and SOX9. Proteomic analysis identified potential chondroinductive factors in the PN-DCM scaffolds, including CYTL1, CTGF, MGP, ITGB1, BMP7, and GDF5, which influence HuMSC differentiation. Conclusion: Our findings have demonstrated that the PN-DCM scaffolds promoted HuMSC differentiation towards a nasal chondrocyte phenotype without the supplementation of exogenous growth factors. This outcome is associated with the chondroinductive factors present within the PN-DCM scaffolds.
The PN-DCM scaffolds, derived from porcine nasal septum cartilage by cryo-grinding, induce HuMSCs to become chondrocyte-like without external growth factors. Proteomics showed that PN-DCM's capability relies on preserving specific components.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>38745541</pmid><doi>10.1039/d3tb03077f</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-1847-1703</orcidid><orcidid>https://orcid.org/0009-0007-7957-2122</orcidid><orcidid>https://orcid.org/0000-0002-4165-046X</orcidid></addata></record> |
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| subjects | Animals Cartilage Cell Differentiation Cells, Cultured Chondrocytes Chondrogenesis Collagen (type II) Connective tissue growth factor Decellularized Extracellular Matrix - chemistry Decellularized Extracellular Matrix - pharmacology Differentiation Extracellular matrix Extracellular Matrix - chemistry Extracellular Matrix - metabolism Gene expression Growth differentiation factor 5 Growth factors Humans Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - metabolism Nasal Septum - chemistry Nasal Septum - cytology Phenotypes Plastic surgery Proteomics Regeneration Safranin-O Scaffolds Septum Sox9 protein Stem cells Swine Tissue Engineering Tissue Scaffolds - chemistry Umbilical cord Umbilical Cord - cytology |
| title | Porcine nasal septum cartilage-derived decellularized matrix promotes chondrogenic differentiation of human umbilical mesenchymal stem cells without exogenous growth factors |
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