Effect of dietary supplementation with recombinant human lysozyme on growth performance, antioxidative characteristics, and intestinal health in broiler chickens
Lysozyme is often used as a feed additive to act as an antibacterial protein that boosts the immune system of livestock and poultry while protecting against pathogens. To investigate the effects of recombinant human lysozyme (rhLYZ) from Pichia pastoris and chlortetracycline on broiler chicken'...
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| Veröffentlicht in: | Journal of animal science 2024-01, Vol.102 |
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| container_title | Journal of animal science |
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| creator | Tian, Xuefeng Cao, Heng Yan, Juntong Li, Chunyue Li, Feiyu Li, Yunke Huang, Fei Bao, Chengling Cao, Yunhe Rao, Zhenghua |
| description | Lysozyme is often used as a feed additive to act as an antibacterial protein that boosts the immune system of livestock and poultry while protecting against pathogens. To investigate the effects of recombinant human lysozyme (rhLYZ) from Pichia pastoris and chlortetracycline on broiler chicken's production performance, antioxidant characteristics, and intestinal microbiota, a total of 200, 1-d-old male Arbor Acres broiler chickens (46.53 ± 0.42 g) were selected for a 42-d experiment. Dietary treatments included a basal diet of corn-soybean meal supplemented with either 0 mg/kg (CON), 50 mg/kg aureomycin (ANT), 20 mg/kg rhLYZ (LOW), 60 mg/kg rhLYZ (MEDIUM), or 180 mg/kg rhLYZ (HIGH). Compared with CON, MEDIUM diet increased (P |
| doi_str_mv | 10.1093/jas/skae121 |
| format | Article |
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To investigate the effects of recombinant human lysozyme (rhLYZ) from Pichia pastoris and chlortetracycline on broiler chicken's production performance, antioxidant characteristics, and intestinal microbiota, a total of 200, 1-d-old male Arbor Acres broiler chickens (46.53 ± 0.42 g) were selected for a 42-d experiment. Dietary treatments included a basal diet of corn-soybean meal supplemented with either 0 mg/kg (CON), 50 mg/kg aureomycin (ANT), 20 mg/kg rhLYZ (LOW), 60 mg/kg rhLYZ (MEDIUM), or 180 mg/kg rhLYZ (HIGH). Compared with CON, MEDIUM diet increased (P < 0.05) average daily gain (67.40 g) of broilers from day 22 to 42. In the early (1.29) and overall phases (1.69), MEDIUM led to a reduction (P < 0.05) in the feed conversion ratio of broiler chickens. Furthermore, in comparison to the CON and ANT, MEDIUM exhibited reduced (P < 0.05) levels of INF-γ and tumor necrosis factor-α in the serum. In the cecum, the abundance of Monoglobus and Family_XIII_AD3011_group was lower (P < 0.05) in the MEDIUM treatment compared to CON. Overall, supplementation of 60 mg/kg of rhLYZ improved growth performance, nutrient utilization efficiency, and serum immune function, while also influencing the composition of intestinal microbiota. This suggests lysozyme's potential to replace antibiotic additives in feed.</description><identifier>ISSN: 0021-8812</identifier><identifier>ISSN: 1525-3163</identifier><identifier>EISSN: 1525-3163</identifier><identifier>DOI: 10.1093/jas/skae121</identifier><identifier>PMID: 38745481</identifier><language>eng</language><publisher>United States</publisher><subject>Animal Feed - analysis ; Animal Nutritional Physiological Phenomena ; Animals ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Chickens - growth & development ; Diet - veterinary ; Dietary Supplements - analysis ; Gastrointestinal Microbiome - drug effects ; Humans ; Intestines - drug effects ; Male ; Muramidase - metabolism ; Muramidase - pharmacology ; Recombinant Proteins - administration & dosage ; Recombinant Proteins - pharmacology</subject><ispartof>Journal of animal science, 2024-01, Vol.102</ispartof><rights>The Author(s) 2024. Published by Oxford University Press on behalf of the American Society of Animal Science. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c247t-b7763b425f93fc13ba0ecf1ca2ffad37ff9b24f4deeece3ff4778d1f907a73853</cites><orcidid>0000-0003-3940-0928 ; 0009-0005-8215-9991</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38745481$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tian, Xuefeng</creatorcontrib><creatorcontrib>Cao, Heng</creatorcontrib><creatorcontrib>Yan, Juntong</creatorcontrib><creatorcontrib>Li, Chunyue</creatorcontrib><creatorcontrib>Li, Feiyu</creatorcontrib><creatorcontrib>Li, Yunke</creatorcontrib><creatorcontrib>Huang, Fei</creatorcontrib><creatorcontrib>Bao, Chengling</creatorcontrib><creatorcontrib>Cao, Yunhe</creatorcontrib><creatorcontrib>Rao, Zhenghua</creatorcontrib><title>Effect of dietary supplementation with recombinant human lysozyme on growth performance, antioxidative characteristics, and intestinal health in broiler chickens</title><title>Journal of animal science</title><addtitle>J Anim Sci</addtitle><description>Lysozyme is often used as a feed additive to act as an antibacterial protein that boosts the immune system of livestock and poultry while protecting against pathogens. To investigate the effects of recombinant human lysozyme (rhLYZ) from Pichia pastoris and chlortetracycline on broiler chicken's production performance, antioxidant characteristics, and intestinal microbiota, a total of 200, 1-d-old male Arbor Acres broiler chickens (46.53 ± 0.42 g) were selected for a 42-d experiment. Dietary treatments included a basal diet of corn-soybean meal supplemented with either 0 mg/kg (CON), 50 mg/kg aureomycin (ANT), 20 mg/kg rhLYZ (LOW), 60 mg/kg rhLYZ (MEDIUM), or 180 mg/kg rhLYZ (HIGH). Compared with CON, MEDIUM diet increased (P < 0.05) average daily gain (67.40 g) of broilers from day 22 to 42. In the early (1.29) and overall phases (1.69), MEDIUM led to a reduction (P < 0.05) in the feed conversion ratio of broiler chickens. Furthermore, in comparison to the CON and ANT, MEDIUM exhibited reduced (P < 0.05) levels of INF-γ and tumor necrosis factor-α in the serum. In the cecum, the abundance of Monoglobus and Family_XIII_AD3011_group was lower (P < 0.05) in the MEDIUM treatment compared to CON. Overall, supplementation of 60 mg/kg of rhLYZ improved growth performance, nutrient utilization efficiency, and serum immune function, while also influencing the composition of intestinal microbiota. This suggests lysozyme's potential to replace antibiotic additives in feed.</description><subject>Animal Feed - analysis</subject><subject>Animal Nutritional Physiological Phenomena</subject><subject>Animals</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Chickens - growth & development</subject><subject>Diet - veterinary</subject><subject>Dietary Supplements - analysis</subject><subject>Gastrointestinal Microbiome - drug effects</subject><subject>Humans</subject><subject>Intestines - drug effects</subject><subject>Male</subject><subject>Muramidase - metabolism</subject><subject>Muramidase - pharmacology</subject><subject>Recombinant Proteins - administration & dosage</subject><subject>Recombinant Proteins - pharmacology</subject><issn>0021-8812</issn><issn>1525-3163</issn><issn>1525-3163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1v1DAQhi0EapfSE3fkIxKE-rNOjlVVPqRKvZRz5DgzrNvETm2Hsvwb_mm96tLTaDTPPBrNS8h7zr5w1smzO5vP8r0FLvgrsuFa6Ebyc_mabBgTvGlbLo7J25zvGONCd_qIHMvWKK1aviH_rhDBFRqRjh6KTTua12WZYIZQbPEx0EdftjSBi_Pggw2FbtfZBjrtcvy7m4FW5FeKjxVaIGFMdejgM62kj3_8WCW_gbqtTdYVSD4X7_J-PFIfCtQ22IluwU7V4AMdUvQTpLrh3T2E_I68QTtlOD3UE_Lz69Xt5ffm-ubbj8uL68YJZUozGHMuByU0dhIdl4Nl4JA7KxDtKA1iNwiFagQABxJRGdOOHDtmrJGtlifk47N3SfFhrXf1s88OpskGiGvuJdNaqbbje_TTM-pSzDkB9kvyc_1dz1m_z6SvmfSHTCr94SBehxnGF_Z_CPIJXbyPWw</recordid><startdate>20240103</startdate><enddate>20240103</enddate><creator>Tian, Xuefeng</creator><creator>Cao, Heng</creator><creator>Yan, Juntong</creator><creator>Li, Chunyue</creator><creator>Li, Feiyu</creator><creator>Li, Yunke</creator><creator>Huang, Fei</creator><creator>Bao, Chengling</creator><creator>Cao, Yunhe</creator><creator>Rao, Zhenghua</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3940-0928</orcidid><orcidid>https://orcid.org/0009-0005-8215-9991</orcidid></search><sort><creationdate>20240103</creationdate><title>Effect of dietary supplementation with recombinant human lysozyme on growth performance, antioxidative characteristics, and intestinal health in broiler chickens</title><author>Tian, Xuefeng ; Cao, Heng ; Yan, Juntong ; Li, Chunyue ; Li, Feiyu ; Li, Yunke ; Huang, Fei ; Bao, Chengling ; Cao, Yunhe ; Rao, Zhenghua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c247t-b7763b425f93fc13ba0ecf1ca2ffad37ff9b24f4deeece3ff4778d1f907a73853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal Feed - analysis</topic><topic>Animal Nutritional Physiological Phenomena</topic><topic>Animals</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Chickens - growth & development</topic><topic>Diet - veterinary</topic><topic>Dietary Supplements - analysis</topic><topic>Gastrointestinal Microbiome - drug effects</topic><topic>Humans</topic><topic>Intestines - drug effects</topic><topic>Male</topic><topic>Muramidase - metabolism</topic><topic>Muramidase - pharmacology</topic><topic>Recombinant Proteins - administration & dosage</topic><topic>Recombinant Proteins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tian, Xuefeng</creatorcontrib><creatorcontrib>Cao, Heng</creatorcontrib><creatorcontrib>Yan, Juntong</creatorcontrib><creatorcontrib>Li, Chunyue</creatorcontrib><creatorcontrib>Li, Feiyu</creatorcontrib><creatorcontrib>Li, Yunke</creatorcontrib><creatorcontrib>Huang, Fei</creatorcontrib><creatorcontrib>Bao, Chengling</creatorcontrib><creatorcontrib>Cao, Yunhe</creatorcontrib><creatorcontrib>Rao, Zhenghua</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tian, Xuefeng</au><au>Cao, Heng</au><au>Yan, Juntong</au><au>Li, Chunyue</au><au>Li, Feiyu</au><au>Li, Yunke</au><au>Huang, Fei</au><au>Bao, Chengling</au><au>Cao, Yunhe</au><au>Rao, Zhenghua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of dietary supplementation with recombinant human lysozyme on growth performance, antioxidative characteristics, and intestinal health in broiler chickens</atitle><jtitle>Journal of animal science</jtitle><addtitle>J Anim Sci</addtitle><date>2024-01-03</date><risdate>2024</risdate><volume>102</volume><issn>0021-8812</issn><issn>1525-3163</issn><eissn>1525-3163</eissn><abstract>Lysozyme is often used as a feed additive to act as an antibacterial protein that boosts the immune system of livestock and poultry while protecting against pathogens. To investigate the effects of recombinant human lysozyme (rhLYZ) from Pichia pastoris and chlortetracycline on broiler chicken's production performance, antioxidant characteristics, and intestinal microbiota, a total of 200, 1-d-old male Arbor Acres broiler chickens (46.53 ± 0.42 g) were selected for a 42-d experiment. Dietary treatments included a basal diet of corn-soybean meal supplemented with either 0 mg/kg (CON), 50 mg/kg aureomycin (ANT), 20 mg/kg rhLYZ (LOW), 60 mg/kg rhLYZ (MEDIUM), or 180 mg/kg rhLYZ (HIGH). Compared with CON, MEDIUM diet increased (P < 0.05) average daily gain (67.40 g) of broilers from day 22 to 42. In the early (1.29) and overall phases (1.69), MEDIUM led to a reduction (P < 0.05) in the feed conversion ratio of broiler chickens. Furthermore, in comparison to the CON and ANT, MEDIUM exhibited reduced (P < 0.05) levels of INF-γ and tumor necrosis factor-α in the serum. In the cecum, the abundance of Monoglobus and Family_XIII_AD3011_group was lower (P < 0.05) in the MEDIUM treatment compared to CON. Overall, supplementation of 60 mg/kg of rhLYZ improved growth performance, nutrient utilization efficiency, and serum immune function, while also influencing the composition of intestinal microbiota. This suggests lysozyme's potential to replace antibiotic additives in feed.</abstract><cop>United States</cop><pmid>38745481</pmid><doi>10.1093/jas/skae121</doi><orcidid>https://orcid.org/0000-0003-3940-0928</orcidid><orcidid>https://orcid.org/0009-0005-8215-9991</orcidid></addata></record> |
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| source | MEDLINE; Oxford University Press Journals Current; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Animal Feed - analysis Animal Nutritional Physiological Phenomena Animals Antioxidants - metabolism Antioxidants - pharmacology Chickens - growth & development Diet - veterinary Dietary Supplements - analysis Gastrointestinal Microbiome - drug effects Humans Intestines - drug effects Male Muramidase - metabolism Muramidase - pharmacology Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacology |
| title | Effect of dietary supplementation with recombinant human lysozyme on growth performance, antioxidative characteristics, and intestinal health in broiler chickens |
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