The subcommissural organ regulates brain development via secreted peptides

The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain region...

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Veröffentlicht in:	Nature neuroscience 2024-06, Vol.27 (6), p.1103-1115
Hauptverfasser:	Zhang, Tingting, Ai, Daosheng, Wei, Pingli, Xu, Ying, Bi, Zhanying, Ma, Fengfei, Li, Fengzhi, Chen, Xing-jun, Zhang, Zhaohuan, Zou, Xiaoxiao, Guo, Zongpei, Zhao, Yue, Li, Jun-Liszt, Ye, Meng, Feng, Ziyan, Zhang, Xinshuang, Zheng, Lijun, Yu, Jie, Li, Chunli, Tu, Tianqi, Zeng, Hongkui, Lei, Jianfeng, Zhang, Hongqi, Hong, Tao, Zhang, Li, Luo, Benyan, Li, Zhen, Xing, Chao, Jia, Chenxi, Li, Lingjun, Sun, Wenzhi, Ge, Woo-ping
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/109 13/51 14 14/1 14/28 14/32 14/34 14/63 45 45/47 45/91 59 59/57 631/136/368/2430 631/378/2571/1696 64 82 82/58 Ablation Animal Genetics and Genomics Animals Axonogenesis Axons Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Brain - embryology Brain - growth & development Brain - metabolism Cell migration Cell Movement - physiology Cre recombinase Defects Embryogenesis Embryonic growth stage Gene Expression Regulation, Developmental Genes Hydrocephalus Hydrocephalus - genetics Hydrocephalus - metabolism Hydrocephalus - pathology Mice Mice, Inbred C57BL Mice, Transgenic Neurobiology Neurons - metabolism Neurosciences Peptides Peptides - metabolism Reintroduction Subcommissural organ Subcommissural Organ - metabolism Thymosin - genetics Thymosin - metabolism Transcriptomes
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