The subcommissural organ regulates brain development via secreted peptides
The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain region...
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| Veröffentlicht in: | Nature neuroscience 2024-06, Vol.27 (6), p.1103-1115 |
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| creator | Zhang, Tingting Ai, Daosheng Wei, Pingli Xu, Ying Bi, Zhanying Ma, Fengfei Li, Fengzhi Chen, Xing-jun Zhang, Zhaohuan Zou, Xiaoxiao Guo, Zongpei Zhao, Yue Li, Jun-Liszt Ye, Meng Feng, Ziyan Zhang, Xinshuang Zheng, Lijun Yu, Jie Li, Chunli Tu, Tianqi Zeng, Hongkui Lei, Jianfeng Zhang, Hongqi Hong, Tao Zhang, Li Luo, Benyan Li, Zhen Xing, Chao Jia, Chenxi Li, Lingjun Sun, Wenzhi Ge, Woo-ping |
| description | The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes,
Sspo
,
Car3
and
Spdef
, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development.
The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects. |
| doi_str_mv | 10.1038/s41593-024-01639-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3054840421</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3054840421</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-290587c236e2fec04f3f5932cd8cda8994ac8baaa0c8809ee914d0d90431929e3</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EglL4ARYoEhs2gfEjjr1EiKeQ2JS15TqTkiov7KQqf4-hBSQWrDySz9yZOYScULigwNVlEDTTPAUmUqCS63S9QyY0EzKlOZO7sQadp5Jl8oAchrAEgDxTep8ccJULCgwm5HH2ikkY565rmiqE0ds66fzCtonHxVjbAUMy97ZqkwJXWHd9g-2QrCqbBHQeByySHvuhKjAckb3S1gGPt--UvNzezK7v06fnu4frq6fUcSaHlGnIVO4Yl8hKdCBKXsYzmCuUK6zSWlin5tZacEqBRtRUFFBoEJxqppFPyfkmt_fd24hhMHFzh3VtW-zGYDhkQgkQjEb07A-67Ebfxu0iJTPKWA4yUmxDOd-F4LE0va8a698NBfNp2mxMm2jafJk269h0uo0e5w0WPy3faiPAN0CIX-0C_e_sf2I_AAVDiaI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3065122706</pqid></control><display><type>article</type><title>The subcommissural organ regulates brain development via secreted peptides</title><source>MEDLINE</source><source>Nature</source><source>Alma/SFX Local Collection</source><creator>Zhang, Tingting ; Ai, Daosheng ; Wei, Pingli ; Xu, Ying ; Bi, Zhanying ; Ma, Fengfei ; Li, Fengzhi ; Chen, Xing-jun ; Zhang, Zhaohuan ; Zou, Xiaoxiao ; Guo, Zongpei ; Zhao, Yue ; Li, Jun-Liszt ; Ye, Meng ; Feng, Ziyan ; Zhang, Xinshuang ; Zheng, Lijun ; Yu, Jie ; Li, Chunli ; Tu, Tianqi ; Zeng, Hongkui ; Lei, Jianfeng ; Zhang, Hongqi ; Hong, Tao ; Zhang, Li ; Luo, Benyan ; Li, Zhen ; Xing, Chao ; Jia, Chenxi ; Li, Lingjun ; Sun, Wenzhi ; Ge, Woo-ping</creator><creatorcontrib>Zhang, Tingting ; Ai, Daosheng ; Wei, Pingli ; Xu, Ying ; Bi, Zhanying ; Ma, Fengfei ; Li, Fengzhi ; Chen, Xing-jun ; Zhang, Zhaohuan ; Zou, Xiaoxiao ; Guo, Zongpei ; Zhao, Yue ; Li, Jun-Liszt ; Ye, Meng ; Feng, Ziyan ; Zhang, Xinshuang ; Zheng, Lijun ; Yu, Jie ; Li, Chunli ; Tu, Tianqi ; Zeng, Hongkui ; Lei, Jianfeng ; Zhang, Hongqi ; Hong, Tao ; Zhang, Li ; Luo, Benyan ; Li, Zhen ; Xing, Chao ; Jia, Chenxi ; Li, Lingjun ; Sun, Wenzhi ; Ge, Woo-ping</creatorcontrib><description>The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes,
Sspo
,
Car3
and
Spdef
, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development.
The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects.</description><identifier>ISSN: 1097-6256</identifier><identifier>ISSN: 1546-1726</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/s41593-024-01639-x</identifier><identifier>PMID: 38741020</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>13 ; 13/1 ; 13/109 ; 13/51 ; 14 ; 14/1 ; 14/28 ; 14/32 ; 14/34 ; 14/63 ; 45 ; 45/47 ; 45/91 ; 59 ; 59/57 ; 631/136/368/2430 ; 631/378/2571/1696 ; 64 ; 82 ; 82/58 ; Ablation ; Animal Genetics and Genomics ; Animals ; Axonogenesis ; Axons ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Brain - embryology ; Brain - growth & development ; Brain - metabolism ; Cell migration ; Cell Movement - physiology ; Cre recombinase ; Defects ; Embryogenesis ; Embryonic growth stage ; Gene Expression Regulation, Developmental ; Genes ; Hydrocephalus ; Hydrocephalus - genetics ; Hydrocephalus - metabolism ; Hydrocephalus - pathology ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Neurobiology ; Neurons - metabolism ; Neurosciences ; Peptides ; Peptides - metabolism ; Reintroduction ; Subcommissural organ ; Subcommissural Organ - metabolism ; Thymosin - genetics ; Thymosin - metabolism ; Transcriptomes</subject><ispartof>Nature neuroscience, 2024-06, Vol.27 (6), p.1103-1115</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Nature America, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-290587c236e2fec04f3f5932cd8cda8994ac8baaa0c8809ee914d0d90431929e3</cites><orcidid>0000-0003-4202-4724 ; 0000-0003-0056-3869 ; 0000-0001-8219-1055 ; 0000-0001-9282-9526 ; 0000-0002-1838-0502</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38741020$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Tingting</creatorcontrib><creatorcontrib>Ai, Daosheng</creatorcontrib><creatorcontrib>Wei, Pingli</creatorcontrib><creatorcontrib>Xu, Ying</creatorcontrib><creatorcontrib>Bi, Zhanying</creatorcontrib><creatorcontrib>Ma, Fengfei</creatorcontrib><creatorcontrib>Li, Fengzhi</creatorcontrib><creatorcontrib>Chen, Xing-jun</creatorcontrib><creatorcontrib>Zhang, Zhaohuan</creatorcontrib><creatorcontrib>Zou, Xiaoxiao</creatorcontrib><creatorcontrib>Guo, Zongpei</creatorcontrib><creatorcontrib>Zhao, Yue</creatorcontrib><creatorcontrib>Li, Jun-Liszt</creatorcontrib><creatorcontrib>Ye, Meng</creatorcontrib><creatorcontrib>Feng, Ziyan</creatorcontrib><creatorcontrib>Zhang, Xinshuang</creatorcontrib><creatorcontrib>Zheng, Lijun</creatorcontrib><creatorcontrib>Yu, Jie</creatorcontrib><creatorcontrib>Li, Chunli</creatorcontrib><creatorcontrib>Tu, Tianqi</creatorcontrib><creatorcontrib>Zeng, Hongkui</creatorcontrib><creatorcontrib>Lei, Jianfeng</creatorcontrib><creatorcontrib>Zhang, Hongqi</creatorcontrib><creatorcontrib>Hong, Tao</creatorcontrib><creatorcontrib>Zhang, Li</creatorcontrib><creatorcontrib>Luo, Benyan</creatorcontrib><creatorcontrib>Li, Zhen</creatorcontrib><creatorcontrib>Xing, Chao</creatorcontrib><creatorcontrib>Jia, Chenxi</creatorcontrib><creatorcontrib>Li, Lingjun</creatorcontrib><creatorcontrib>Sun, Wenzhi</creatorcontrib><creatorcontrib>Ge, Woo-ping</creatorcontrib><title>The subcommissural organ regulates brain development via secreted peptides</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes,
Sspo
,
Car3
and
Spdef
, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development.
The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects.</description><subject>13</subject><subject>13/1</subject><subject>13/109</subject><subject>13/51</subject><subject>14</subject><subject>14/1</subject><subject>14/28</subject><subject>14/32</subject><subject>14/34</subject><subject>14/63</subject><subject>45</subject><subject>45/47</subject><subject>45/91</subject><subject>59</subject><subject>59/57</subject><subject>631/136/368/2430</subject><subject>631/378/2571/1696</subject><subject>64</subject><subject>82</subject><subject>82/58</subject><subject>Ablation</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Axonogenesis</subject><subject>Axons</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Brain - embryology</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Cell migration</subject><subject>Cell Movement - physiology</subject><subject>Cre recombinase</subject><subject>Defects</subject><subject>Embryogenesis</subject><subject>Embryonic growth stage</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Genes</subject><subject>Hydrocephalus</subject><subject>Hydrocephalus - genetics</subject><subject>Hydrocephalus - metabolism</subject><subject>Hydrocephalus - pathology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Transgenic</subject><subject>Neurobiology</subject><subject>Neurons - metabolism</subject><subject>Neurosciences</subject><subject>Peptides</subject><subject>Peptides - metabolism</subject><subject>Reintroduction</subject><subject>Subcommissural organ</subject><subject>Subcommissural Organ - metabolism</subject><subject>Thymosin - genetics</subject><subject>Thymosin - metabolism</subject><subject>Transcriptomes</subject><issn>1097-6256</issn><issn>1546-1726</issn><issn>1546-1726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EglL4ARYoEhs2gfEjjr1EiKeQ2JS15TqTkiov7KQqf4-hBSQWrDySz9yZOYScULigwNVlEDTTPAUmUqCS63S9QyY0EzKlOZO7sQadp5Jl8oAchrAEgDxTep8ccJULCgwm5HH2ikkY565rmiqE0ds66fzCtonHxVjbAUMy97ZqkwJXWHd9g-2QrCqbBHQeByySHvuhKjAckb3S1gGPt--UvNzezK7v06fnu4frq6fUcSaHlGnIVO4Yl8hKdCBKXsYzmCuUK6zSWlin5tZacEqBRtRUFFBoEJxqppFPyfkmt_fd24hhMHFzh3VtW-zGYDhkQgkQjEb07A-67Ebfxu0iJTPKWA4yUmxDOd-F4LE0va8a698NBfNp2mxMm2jafJk269h0uo0e5w0WPy3faiPAN0CIX-0C_e_sf2I_AAVDiaI</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Zhang, Tingting</creator><creator>Ai, Daosheng</creator><creator>Wei, Pingli</creator><creator>Xu, Ying</creator><creator>Bi, Zhanying</creator><creator>Ma, Fengfei</creator><creator>Li, Fengzhi</creator><creator>Chen, Xing-jun</creator><creator>Zhang, Zhaohuan</creator><creator>Zou, Xiaoxiao</creator><creator>Guo, Zongpei</creator><creator>Zhao, Yue</creator><creator>Li, Jun-Liszt</creator><creator>Ye, Meng</creator><creator>Feng, Ziyan</creator><creator>Zhang, Xinshuang</creator><creator>Zheng, Lijun</creator><creator>Yu, Jie</creator><creator>Li, Chunli</creator><creator>Tu, Tianqi</creator><creator>Zeng, Hongkui</creator><creator>Lei, Jianfeng</creator><creator>Zhang, Hongqi</creator><creator>Hong, Tao</creator><creator>Zhang, Li</creator><creator>Luo, Benyan</creator><creator>Li, Zhen</creator><creator>Xing, Chao</creator><creator>Jia, Chenxi</creator><creator>Li, Lingjun</creator><creator>Sun, Wenzhi</creator><creator>Ge, Woo-ping</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4202-4724</orcidid><orcidid>https://orcid.org/0000-0003-0056-3869</orcidid><orcidid>https://orcid.org/0000-0001-8219-1055</orcidid><orcidid>https://orcid.org/0000-0001-9282-9526</orcidid><orcidid>https://orcid.org/0000-0002-1838-0502</orcidid></search><sort><creationdate>202406</creationdate><title>The subcommissural organ regulates brain development via secreted peptides</title><author>Zhang, Tingting ; Ai, Daosheng ; Wei, Pingli ; Xu, Ying ; Bi, Zhanying ; Ma, Fengfei ; Li, Fengzhi ; Chen, Xing-jun ; Zhang, Zhaohuan ; Zou, Xiaoxiao ; Guo, Zongpei ; Zhao, Yue ; Li, Jun-Liszt ; Ye, Meng ; Feng, Ziyan ; Zhang, Xinshuang ; Zheng, Lijun ; Yu, Jie ; Li, Chunli ; Tu, Tianqi ; Zeng, Hongkui ; Lei, Jianfeng ; Zhang, Hongqi ; Hong, Tao ; Zhang, Li ; Luo, Benyan ; Li, Zhen ; Xing, Chao ; Jia, Chenxi ; Li, Lingjun ; Sun, Wenzhi ; Ge, Woo-ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-290587c236e2fec04f3f5932cd8cda8994ac8baaa0c8809ee914d0d90431929e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>13</topic><topic>13/1</topic><topic>13/109</topic><topic>13/51</topic><topic>14</topic><topic>14/1</topic><topic>14/28</topic><topic>14/32</topic><topic>14/34</topic><topic>14/63</topic><topic>45</topic><topic>45/47</topic><topic>45/91</topic><topic>59</topic><topic>59/57</topic><topic>631/136/368/2430</topic><topic>631/378/2571/1696</topic><topic>64</topic><topic>82</topic><topic>82/58</topic><topic>Ablation</topic><topic>Animal Genetics and Genomics</topic><topic>Animals</topic><topic>Axonogenesis</topic><topic>Axons</topic><topic>Behavioral Sciences</topic><topic>Biological Techniques</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Brain - 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Zongpei</au><au>Zhao, Yue</au><au>Li, Jun-Liszt</au><au>Ye, Meng</au><au>Feng, Ziyan</au><au>Zhang, Xinshuang</au><au>Zheng, Lijun</au><au>Yu, Jie</au><au>Li, Chunli</au><au>Tu, Tianqi</au><au>Zeng, Hongkui</au><au>Lei, Jianfeng</au><au>Zhang, Hongqi</au><au>Hong, Tao</au><au>Zhang, Li</au><au>Luo, Benyan</au><au>Li, Zhen</au><au>Xing, Chao</au><au>Jia, Chenxi</au><au>Li, Lingjun</au><au>Sun, Wenzhi</au><au>Ge, Woo-ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The subcommissural organ regulates brain development via secreted peptides</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2024-06</date><risdate>2024</risdate><volume>27</volume><issue>6</issue><spage>1103</spage><epage>1115</epage><pages>1103-1115</pages><issn>1097-6256</issn><issn>1546-1726</issn><eissn>1546-1726</eissn><abstract>The subcommissural organ (SCO) is a gland located at the entrance of the aqueduct of Sylvius in the brain. It exists in species as distantly related as amphioxus and humans, but its function is largely unknown. Here, to explore its function, we compared transcriptomes of SCO and non-SCO brain regions and found three genes,
Sspo
,
Car3
and
Spdef
, that are highly expressed in the SCO. Mouse strains expressing Cre recombinase from endogenous promoter/enhancer elements of these genes were used to genetically ablate SCO cells during embryonic development, resulting in severe hydrocephalus and defects in neuronal migration and development of neuronal axons and dendrites. Unbiased peptidomic analysis revealed enrichment of three SCO-derived peptides, namely, thymosin beta 4, thymosin beta 10 and NP24, and their reintroduction into SCO-ablated brain ventricles substantially rescued developmental defects. Together, these data identify a critical role for the SCO in brain development.
The subcommissural organ (SCO) is a gland in the brain, and relatively little is known about its function. Zhang et al. genetically ablated SCO cells and observed severe hydrocephalus and neuronal defects. The reintroduction of SCO-derived peptides into SCO-ablated brain substantially rescued developmental defects.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>38741020</pmid><doi>10.1038/s41593-024-01639-x</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4202-4724</orcidid><orcidid>https://orcid.org/0000-0003-0056-3869</orcidid><orcidid>https://orcid.org/0000-0001-8219-1055</orcidid><orcidid>https://orcid.org/0000-0001-9282-9526</orcidid><orcidid>https://orcid.org/0000-0002-1838-0502</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1097-6256 |
| ispartof | Nature neuroscience, 2024-06, Vol.27 (6), p.1103-1115 |
| issn | 1097-6256 1546-1726 1546-1726 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3054840421 |
| source | MEDLINE; Nature; Alma/SFX Local Collection |
| subjects | 13 13/1 13/109 13/51 14 14/1 14/28 14/32 14/34 14/63 45 45/47 45/91 59 59/57 631/136/368/2430 631/378/2571/1696 64 82 82/58 Ablation Animal Genetics and Genomics Animals Axonogenesis Axons Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Brain Brain - embryology Brain - growth & development Brain - metabolism Cell migration Cell Movement - physiology Cre recombinase Defects Embryogenesis Embryonic growth stage Gene Expression Regulation, Developmental Genes Hydrocephalus Hydrocephalus - genetics Hydrocephalus - metabolism Hydrocephalus - pathology Mice Mice, Inbred C57BL Mice, Transgenic Neurobiology Neurons - metabolism Neurosciences Peptides Peptides - metabolism Reintroduction Subcommissural organ Subcommissural Organ - metabolism Thymosin - genetics Thymosin - metabolism Transcriptomes |
| title | The subcommissural organ regulates brain development via secreted peptides |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-30T22%3A51%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20subcommissural%20organ%20regulates%20brain%20development%20via%20secreted%20peptides&rft.jtitle=Nature%20neuroscience&rft.au=Zhang,%20Tingting&rft.date=2024-06&rft.volume=27&rft.issue=6&rft.spage=1103&rft.epage=1115&rft.pages=1103-1115&rft.issn=1097-6256&rft.eissn=1546-1726&rft_id=info:doi/10.1038/s41593-024-01639-x&rft_dat=%3Cproquest_cross%3E3054840421%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3065122706&rft_id=info:pmid/38741020&rfr_iscdi=true |