Nebulized Inhalation of Peptide-Modified DNA Origami To Alleviate Acute Lung Injury

Acute lung injury (ALI) is a severe inflammatory lung disease, with high mortality rates. Early intervention by reactive oxygen species (ROS) scavengers could reduce ROS accumulation, break the inflammation expansion chain in alveolar macrophages (AMs), and avoid irreversible damage to alveolar epit...

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Veröffentlicht in:	Nano letters 2024-05, Vol.24 (20), p.6102-6111
Hauptverfasser:	Wang, Haiyan, Jiao, Yunfei, Ma, Shuaijing, Li, Zhuoting, Gong, Jintao, Jiang, Qiao, Shang, Yingxu, Li, Hongling, Li, Jing, Li, Na, Zhao, Robert Chunhua, Ding, Baoquan
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - chemically induced Acute Lung Injury - drug therapy Acute Lung Injury - pathology Administration, Inhalation Animals Cell-Penetrating Peptides - chemistry Cytokines - metabolism Disease Models, Animal DNA - chemistry Drug Delivery Systems Lipopolysaccharides Macrophages, Alveolar - drug effects Macrophages, Alveolar - metabolism Mice Nanostructures - chemistry Nebulizers and Vaporizers Peptides - chemistry RAW 264.7 Cells Reactive Oxygen Species - metabolism
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