Plasmid targeting and destruction by the DdmDE bacterial defence system

Although eukaryotic Argonautes have a pivotal role in post-transcriptional gene regulation through nucleic acid cleavage, some short prokaryotic Argonaute variants (pAgos) rely on auxiliary nuclease factors for efficient foreign DNA degradation 1 . Here we reveal the activation pathway of the DNA de...

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Veröffentlicht in:	Nature (London) 2024-06, Vol.630 (8018), p.961-967
Hauptverfasser:	Bravo, Jack P. K., Ramos, Delisa A., Fregoso Ocampo, Rodrigo, Ingram, Caiden, Taylor, David W.
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/326/88 631/45/500 631/535/1258/1259 Antibiotics Argonaute Proteins - chemistry Argonaute Proteins - metabolism Argonaute Proteins - ultrastructure Bacteria Bacterial Proteins - chemistry Bacterial Proteins - metabolism Bacterial Proteins - ultrastructure Biochemistry Clearances Cryoelectron Microscopy Defense Deoxyribonucleases - chemistry Deoxyribonucleases - metabolism Deoxyribonucleases - ultrastructure Deoxyribonucleic acid DNA DNA helicase DNA Helicases - chemistry DNA Helicases - metabolism DNA Helicases - ultrastructure DNA structure DNA, Single-Stranded - genetics DNA, Single-Stranded - metabolism Electron microscopy Gene regulation Genomes Humanities and Social Sciences Microscopy Models, Molecular multidisciplinary Mutation Nuclease Nucleic acids Plasmids Plasmids - genetics Plasmids - immunology Plasmids - metabolism Post-transcription Protein Domains Protein Multimerization Proteins Science Science (multidisciplinary) Sensors Single-stranded DNA Transcription factors Vibrio cholerae - genetics Vibrio cholerae - immunology Vibrio cholerae - pathogenicity
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