Hollow microneedles for ocular drug delivery
Microneedles (MNs) are micron-sized needles, typically
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| Veröffentlicht in: | Journal of controlled release 2024-07, Vol.371, p.43-66 |
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| container_title | Journal of controlled release |
| container_volume | 371 |
| creator | Gade, Shilpkala Glover, Katie Mishra, Deepakkumar Sharma, Sanjiv Guy, Owen Donnelly, Ryan F. Vora, Lalitkumar K. Thakur, Raghu Raj Singh |
| description | Microneedles (MNs) are micron-sized needles, typically |
| doi_str_mv | 10.1016/j.jconrel.2024.05.013 |
| format | Article |
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[Display omitted]</description><identifier>ISSN: 0168-3659</identifier><identifier>ISSN: 1873-4995</identifier><identifier>EISSN: 1873-4995</identifier><identifier>DOI: 10.1016/j.jconrel.2024.05.013</identifier><identifier>PMID: 38735395</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Administration, Ophthalmic ; Animals ; Drug Delivery Systems ; Eye - metabolism ; Hollow microneedles ; Humans ; Microinjections - instrumentation ; Microinjections - methods ; Microparticles ; Minimally invasive ; Nanoparticles ; Needles ; Optical coherence tomography ; Periocular ; Pharmaceutical Preparations - administration & dosage ; Suprachoroidal ; Transscleral ; Uveitis ; Vasculature</subject><ispartof>Journal of controlled release, 2024-07, Vol.371, p.43-66</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c360t-71e4bb2b010035d18f5642d6e32b77dc3e80421da914f853fd20720cc54f62e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0168365924002979$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38735395$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gade, Shilpkala</creatorcontrib><creatorcontrib>Glover, Katie</creatorcontrib><creatorcontrib>Mishra, Deepakkumar</creatorcontrib><creatorcontrib>Sharma, Sanjiv</creatorcontrib><creatorcontrib>Guy, Owen</creatorcontrib><creatorcontrib>Donnelly, Ryan F.</creatorcontrib><creatorcontrib>Vora, Lalitkumar K.</creatorcontrib><creatorcontrib>Thakur, Raghu Raj Singh</creatorcontrib><title>Hollow microneedles for ocular drug delivery</title><title>Journal of controlled release</title><addtitle>J Control Release</addtitle><description>Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or as single needle. These MNs offer a minimally invasive approach to ocular drug delivery due to their micron size (reducing tissue damage compared to that of hypodermic needles) and overcoming significant barriers in drug administration. While various types of MNs have been extensively researched, significant progress has been made in the use of hollow MNs (HMNs) for ocular drug delivery, specifically through suprachoroidal injections. The suprachoroidal space, situated between the sclera and choroid, has been targeted using optical coherence tomography-guided injections of HMNs for the treatment of uveitis. Unlike other MNs, HMNs can deliver larger volumes of formulations to the eye. This review primarily focuses on the use of HMNs in ocular drug delivery and explores their ocular anatomy and the distribution of formulations following potential HMN administration routes. Additionally, this review focuses on the influence of formulation characteristics (e.g., solution viscosity, particle size), HMN properties (e.g., bore or lumen diameter, MN length), and routes of administration (e.g., periocular transscleral, suprachoroidal, intravitreal) on the ocular distribution of drugs. Overall, this paper highlights the distinctive properties of HMNs, which make them a promising technology for improving drug delivery efficiency, precision, and patient outcomes in the treatment of ocular diseases.
[Display omitted]</description><subject>Administration, Ophthalmic</subject><subject>Animals</subject><subject>Drug Delivery Systems</subject><subject>Eye - metabolism</subject><subject>Hollow microneedles</subject><subject>Humans</subject><subject>Microinjections - instrumentation</subject><subject>Microinjections - methods</subject><subject>Microparticles</subject><subject>Minimally invasive</subject><subject>Nanoparticles</subject><subject>Needles</subject><subject>Optical coherence tomography</subject><subject>Periocular</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Suprachoroidal</subject><subject>Transscleral</subject><subject>Uveitis</subject><subject>Vasculature</subject><issn>0168-3659</issn><issn>1873-4995</issn><issn>1873-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaAsWZAwfuWxQqgCilSJDaytxJ6gRE5d7Kaof4-rFrasZnPu3JlDyDWFjALN7_us127l0WYMmMhAZkD5CZnSsuCpqCp5SqaRK1Oey2pCLkLoAUByUZyTCY-Q5JWckruFs9Z9J0OnvVshGoshaZ1PnB5t7RPjx8_EoO226HeX5KytbcCr45yRj-en9_kiXb69vM4fl6nmOWzSgqJoGtYABeDS0LKVuWAmR86aojCaYwmCUVNXVLSl5K1hUDDQWoo2Z1jxGbk97F179zVi2KihCxqtrVfoxqA4SCF4fEVGVB7QeH4IHlu19t1Q-52ioPaiVK-OotRelAKpoqiYuzlWjM2A5i_1ayYCDwcA46PbDr0KusOVRtN51BtlXPdPxQ-bjXrI</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Gade, Shilpkala</creator><creator>Glover, Katie</creator><creator>Mishra, Deepakkumar</creator><creator>Sharma, Sanjiv</creator><creator>Guy, Owen</creator><creator>Donnelly, Ryan F.</creator><creator>Vora, Lalitkumar K.</creator><creator>Thakur, Raghu Raj Singh</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202407</creationdate><title>Hollow microneedles for ocular drug delivery</title><author>Gade, Shilpkala ; Glover, Katie ; Mishra, Deepakkumar ; Sharma, Sanjiv ; Guy, Owen ; Donnelly, Ryan F. ; Vora, Lalitkumar K. ; Thakur, Raghu Raj Singh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-71e4bb2b010035d18f5642d6e32b77dc3e80421da914f853fd20720cc54f62e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Administration, Ophthalmic</topic><topic>Animals</topic><topic>Drug Delivery Systems</topic><topic>Eye - metabolism</topic><topic>Hollow microneedles</topic><topic>Humans</topic><topic>Microinjections - instrumentation</topic><topic>Microinjections - methods</topic><topic>Microparticles</topic><topic>Minimally invasive</topic><topic>Nanoparticles</topic><topic>Needles</topic><topic>Optical coherence tomography</topic><topic>Periocular</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Suprachoroidal</topic><topic>Transscleral</topic><topic>Uveitis</topic><topic>Vasculature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gade, Shilpkala</creatorcontrib><creatorcontrib>Glover, Katie</creatorcontrib><creatorcontrib>Mishra, Deepakkumar</creatorcontrib><creatorcontrib>Sharma, Sanjiv</creatorcontrib><creatorcontrib>Guy, Owen</creatorcontrib><creatorcontrib>Donnelly, Ryan F.</creatorcontrib><creatorcontrib>Vora, Lalitkumar K.</creatorcontrib><creatorcontrib>Thakur, Raghu Raj Singh</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of controlled release</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gade, Shilpkala</au><au>Glover, Katie</au><au>Mishra, Deepakkumar</au><au>Sharma, Sanjiv</au><au>Guy, Owen</au><au>Donnelly, Ryan F.</au><au>Vora, Lalitkumar K.</au><au>Thakur, Raghu Raj Singh</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hollow microneedles for ocular drug delivery</atitle><jtitle>Journal of controlled release</jtitle><addtitle>J Control Release</addtitle><date>2024-07</date><risdate>2024</risdate><volume>371</volume><spage>43</spage><epage>66</epage><pages>43-66</pages><issn>0168-3659</issn><issn>1873-4995</issn><eissn>1873-4995</eissn><abstract>Microneedles (MNs) are micron-sized needles, typically <2 mm in length, arranged either as an array or as single needle. These MNs offer a minimally invasive approach to ocular drug delivery due to their micron size (reducing tissue damage compared to that of hypodermic needles) and overcoming significant barriers in drug administration. While various types of MNs have been extensively researched, significant progress has been made in the use of hollow MNs (HMNs) for ocular drug delivery, specifically through suprachoroidal injections. The suprachoroidal space, situated between the sclera and choroid, has been targeted using optical coherence tomography-guided injections of HMNs for the treatment of uveitis. Unlike other MNs, HMNs can deliver larger volumes of formulations to the eye. This review primarily focuses on the use of HMNs in ocular drug delivery and explores their ocular anatomy and the distribution of formulations following potential HMN administration routes. Additionally, this review focuses on the influence of formulation characteristics (e.g., solution viscosity, particle size), HMN properties (e.g., bore or lumen diameter, MN length), and routes of administration (e.g., periocular transscleral, suprachoroidal, intravitreal) on the ocular distribution of drugs. Overall, this paper highlights the distinctive properties of HMNs, which make them a promising technology for improving drug delivery efficiency, precision, and patient outcomes in the treatment of ocular diseases.
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| ispartof | Journal of controlled release, 2024-07, Vol.371, p.43-66 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Ophthalmic Animals Drug Delivery Systems Eye - metabolism Hollow microneedles Humans Microinjections - instrumentation Microinjections - methods Microparticles Minimally invasive Nanoparticles Needles Optical coherence tomography Periocular Pharmaceutical Preparations - administration & dosage Suprachoroidal Transscleral Uveitis Vasculature |
| title | Hollow microneedles for ocular drug delivery |
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