Spaced conditioned stimulus presentation facilitates the extinction of strong fear memory in mice
Inducing fear memory extinction by re-presenting a conditioned stimulus (CS) is the foundation of exposure therapy for post-traumatic stress disorder (PTSD). Investigating differences in the ability of different CS presentation patterns to induce extinction learning is crucial for improving this typ...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2024-07, Vol.718, p.150071, Article 150071 |
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| container_title | Biochemical and biophysical research communications |
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| creator | Kawakami, Chinatsu Naoi, Toshie Sakaguchi, Masanori |
| description | Inducing fear memory extinction by re-presenting a conditioned stimulus (CS) is the foundation of exposure therapy for post-traumatic stress disorder (PTSD). Investigating differences in the ability of different CS presentation patterns to induce extinction learning is crucial for improving this type of therapy. Using a trace fear conditioning paradigm in mice, we demonstrate that spaced presentation of the CS facilitated the extinction of a strong fear memory to a greater extent than continuous CS presentation. These results lay the groundwork for developing more effective exposure therapy techniques for PTSD.
•A spaced CS extinguished fear memory similarly for all shock intensities.•A continuous CS extinguished fear memory differently according to shock intensity.•A spaced CS facilitated extinction of a strong fear memory.•A spaced CS extinguished fear memory irrespective of context fear generalization. |
| doi_str_mv | 10.1016/j.bbrc.2024.150071 |
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•A spaced CS extinguished fear memory similarly for all shock intensities.•A continuous CS extinguished fear memory differently according to shock intensity.•A spaced CS facilitated extinction of a strong fear memory.•A spaced CS extinguished fear memory irrespective of context fear generalization.</description><subject>Animals</subject><subject>Auditory cue</subject><subject>Conditioning, Classical - physiology</subject><subject>Conditioning, Psychological - physiology</subject><subject>Exposure therapy</subject><subject>Extinction learning</subject><subject>Extinction, Psychological - physiology</subject><subject>Fear - physiology</subject><subject>Fear - psychology</subject><subject>Generalization</subject><subject>Male</subject><subject>Memory - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Post-traumatic disorder</subject><subject>Stress Disorders, Post-Traumatic - physiopathology</subject><subject>Stress Disorders, Post-Traumatic - psychology</subject><subject>Trace fear conditioning</subject><issn>0006-291X</issn><issn>1090-2104</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFP3DAQha0KVBbaP8Ch8pFLtjO2k91IvSBEoRISB0DqzXLscfEqibd2UrH_vl6WcuzF45l578n-GDtHWCJg83Wz7LpklwKEWmINsMIPbIHQQiUQ1BFbAEBTiRZ_nrDTnDcAiKppP7ITuV7JGmWzYOZhayw5buPowhTiWO55CsPcz5lvE2UaJ7Ofc29s6ENpKPPpmTi9TGG0r6voiyfF8Rf3ZBIfaIhpx8PIh2DpEzv2ps_0-a2esafv149Xt9Xd_c2Pq8u7ypanTBXaznklnGuk7KipXTlXKOrWgzRercmTlOvWQZl5UhbaWth1o9B4ibK28oxdHHK3Kf6eKU96CNlS35uR4py1hFopKYXAIhUHqU0x50Reb1MYTNppBL1Hqzd6j1bv0eoD2mL68pY_dwO5d8s_lkXw7SCg8ss_gZLONtBY6IZEdtIuhv_l_wV61IuW</recordid><startdate>20240723</startdate><enddate>20240723</enddate><creator>Kawakami, Chinatsu</creator><creator>Naoi, Toshie</creator><creator>Sakaguchi, Masanori</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7211-9452</orcidid></search><sort><creationdate>20240723</creationdate><title>Spaced conditioned stimulus presentation facilitates the extinction of strong fear memory in mice</title><author>Kawakami, Chinatsu ; Naoi, Toshie ; Sakaguchi, Masanori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-1cbdf42dd633be65d3be71259f03af48efe3389d0125fe4c0952c8641af3135c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Auditory cue</topic><topic>Conditioning, Classical - physiology</topic><topic>Conditioning, Psychological - physiology</topic><topic>Exposure therapy</topic><topic>Extinction learning</topic><topic>Extinction, Psychological - physiology</topic><topic>Fear - physiology</topic><topic>Fear - psychology</topic><topic>Generalization</topic><topic>Male</topic><topic>Memory - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Post-traumatic disorder</topic><topic>Stress Disorders, Post-Traumatic - physiopathology</topic><topic>Stress Disorders, Post-Traumatic - psychology</topic><topic>Trace fear conditioning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawakami, Chinatsu</creatorcontrib><creatorcontrib>Naoi, Toshie</creatorcontrib><creatorcontrib>Sakaguchi, Masanori</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawakami, Chinatsu</au><au>Naoi, Toshie</au><au>Sakaguchi, Masanori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spaced conditioned stimulus presentation facilitates the extinction of strong fear memory in mice</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2024-07-23</date><risdate>2024</risdate><volume>718</volume><spage>150071</spage><pages>150071-</pages><artnum>150071</artnum><issn>0006-291X</issn><issn>1090-2104</issn><eissn>1090-2104</eissn><abstract>Inducing fear memory extinction by re-presenting a conditioned stimulus (CS) is the foundation of exposure therapy for post-traumatic stress disorder (PTSD). Investigating differences in the ability of different CS presentation patterns to induce extinction learning is crucial for improving this type of therapy. Using a trace fear conditioning paradigm in mice, we demonstrate that spaced presentation of the CS facilitated the extinction of a strong fear memory to a greater extent than continuous CS presentation. These results lay the groundwork for developing more effective exposure therapy techniques for PTSD.
•A spaced CS extinguished fear memory similarly for all shock intensities.•A continuous CS extinguished fear memory differently according to shock intensity.•A spaced CS facilitated extinction of a strong fear memory.•A spaced CS extinguished fear memory irrespective of context fear generalization.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38735136</pmid><doi>10.1016/j.bbrc.2024.150071</doi><orcidid>https://orcid.org/0000-0002-7211-9452</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 2024-07, Vol.718, p.150071, Article 150071 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Auditory cue Conditioning, Classical - physiology Conditioning, Psychological - physiology Exposure therapy Extinction learning Extinction, Psychological - physiology Fear - physiology Fear - psychology Generalization Male Memory - physiology Mice Mice, Inbred C57BL Post-traumatic disorder Stress Disorders, Post-Traumatic - physiopathology Stress Disorders, Post-Traumatic - psychology Trace fear conditioning |
| title | Spaced conditioned stimulus presentation facilitates the extinction of strong fear memory in mice |
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