Current Place of SGLT2i in the Management of Heart Failure: An Expert Opinion from India
Heart failure (HF) is a global health concern that is prevalent in India as well. HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new...
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| Veröffentlicht in: | Journal of the Association of Physicians of India 2024-01, Vol.72 (1), p.63 |
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| creator | Chopra, H K Nair, Tiny Wander, G S Ponde, C K Ray, Saumitra Khullar, Dinesh Nanda, Navin C Narula, Jagat Kasliwal, Ravi R Rana, D S Kirpalani, Ashok Sawhney, J P S Chandra, Praveen Mehta, Yatin Kumar, Viveka Tewari, S Pancholia, A K Kher, Vijay Bansal, Sandeep Mittal, Sanjay Kerkar, Praful Sahoo, P K Hotchandani, Ramesh Prakash, Sunil Chauhan, Nagendra Rastogi, Vishal Jabir, A Shanmugasundaram, S Tiwaskar, Mangesh Sinha, Ajay Gupta, Vittul Mishra, S S Routray, S N Omar, A K Swami, Onkar C Jaswal, Aparna Alam, Shamsad Passey, Rajeev Rajput, Rajeeve Paul, Justin Kapoor, Aditya Prabhakar, D Chandra, Subhash Malhotra, Poonam Singh, Vivudh Pratap Bansal, Manish Shah, Priyank Jain, Sanjay Bhargava, Mohan Vijayalakshmi, I B Varghaese, Kiron Jain, Dharmender Goel, Anupam Mehmood, Kiran Gaur, Namrata Tandon, Rohit Moorthy, Asha George, Sheeba Katyal, V K Mantri, R R Mehrotra, Rahul Bhalla, Dilip Mittal, Vinod Rao, Sarita Jagia, Manish Singh, Harmeet Awasthi, Surabhi Sattur, Ameet Mishra, Rekha Pandey, Anand Chawla, Rajeev Jaggi, Shalini Sehgal, Blessy Sehgal, Alok Goel, Naresh Gupta, Ripen Kubba, Samir Chhabra, Abhinav Bagga, Saurabh Shastry, N R |
| description | Heart failure (HF) is a global health concern that is prevalent in India as well. HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new guideline-recommended and approved treatment strategies for HF. Extensive evidence highlights that SGLT2i exhibits profound cardiovascular (CV) benefits beyond glycemic control. SGLT2i, in conjunction with other guideline-directed medical therapies (GMDT), has additive effects in improving heart function and reducing adverse HF outcomes. The benefits of SGLT2i are across a spectrum of patients, with and without diabetes, suggesting their potential place in broader HF populations irrespective of ejection fraction (EF). This consensus builds on the updated evidence of the efficacy and safety of SGLT2i in HF and recommends its place in therapy with a focus on Indian patients with HF. |
| doi_str_mv | 10.59556/japi.71.0440 |
| format | Article |
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HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new guideline-recommended and approved treatment strategies for HF. Extensive evidence highlights that SGLT2i exhibits profound cardiovascular (CV) benefits beyond glycemic control. SGLT2i, in conjunction with other guideline-directed medical therapies (GMDT), has additive effects in improving heart function and reducing adverse HF outcomes. The benefits of SGLT2i are across a spectrum of patients, with and without diabetes, suggesting their potential place in broader HF populations irrespective of ejection fraction (EF). This consensus builds on the updated evidence of the efficacy and safety of SGLT2i in HF and recommends its place in therapy with a focus on Indian patients with HF.</description><identifier>ISSN: 0004-5772</identifier><identifier>DOI: 10.59556/japi.71.0440</identifier><identifier>PMID: 38736076</identifier><language>eng</language><publisher>India</publisher><subject>Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - drug therapy ; Heart Failure - drug therapy ; Humans ; India ; Sodium-Glucose Transporter 2 Inhibitors - therapeutic use</subject><ispartof>Journal of the Association of Physicians of India, 2024-01, Vol.72 (1), p.63</ispartof><rights>Journal of the Association of Physicians of India 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HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new guideline-recommended and approved treatment strategies for HF. Extensive evidence highlights that SGLT2i exhibits profound cardiovascular (CV) benefits beyond glycemic control. SGLT2i, in conjunction with other guideline-directed medical therapies (GMDT), has additive effects in improving heart function and reducing adverse HF outcomes. The benefits of SGLT2i are across a spectrum of patients, with and without diabetes, suggesting their potential place in broader HF populations irrespective of ejection fraction (EF). 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Rajeev</creatorcontrib><creatorcontrib>Jaggi, Shalini</creatorcontrib><creatorcontrib>Sehgal, Blessy</creatorcontrib><creatorcontrib>Sehgal, Alok</creatorcontrib><creatorcontrib>Goel, Naresh</creatorcontrib><creatorcontrib>Gupta, Ripen</creatorcontrib><creatorcontrib>Kubba, Samir</creatorcontrib><creatorcontrib>Chhabra, Abhinav</creatorcontrib><creatorcontrib>Bagga, Saurabh</creatorcontrib><creatorcontrib>Shastry, N R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the Association of Physicians of India</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chopra, H K</au><au>Nair, Tiny</au><au>Wander, G S</au><au>Ponde, C K</au><au>Ray, Saumitra</au><au>Khullar, Dinesh</au><au>Nanda, Navin C</au><au>Narula, Jagat</au><au>Kasliwal, Ravi R</au><au>Rana, D S</au><au>Kirpalani, Ashok</au><au>Sawhney, J P S</au><au>Chandra, Praveen</au><au>Mehta, Yatin</au><au>Kumar, Viveka</au><au>Tewari, S</au><au>Pancholia, A K</au><au>Kher, Vijay</au><au>Bansal, Sandeep</au><au>Mittal, Sanjay</au><au>Kerkar, Praful</au><au>Sahoo, P K</au><au>Hotchandani, Ramesh</au><au>Prakash, Sunil</au><au>Chauhan, Nagendra</au><au>Rastogi, Vishal</au><au>Jabir, A</au><au>Shanmugasundaram, S</au><au>Tiwaskar, Mangesh</au><au>Sinha, Ajay</au><au>Gupta, Vittul</au><au>Mishra, S S</au><au>Routray, S N</au><au>Omar, A K</au><au>Swami, Onkar C</au><au>Jaswal, Aparna</au><au>Alam, Shamsad</au><au>Passey, Rajeev</au><au>Rajput, Rajeeve</au><au>Paul, Justin</au><au>Kapoor, Aditya</au><au>Prabhakar, D</au><au>Chandra, Subhash</au><au>Malhotra, Poonam</au><au>Singh, Vivudh Pratap</au><au>Bansal, Manish</au><au>Shah, Priyank</au><au>Jain, Sanjay</au><au>Bhargava, Mohan</au><au>Vijayalakshmi, I B</au><au>Varghaese, Kiron</au><au>Jain, Dharmender</au><au>Goel, Anupam</au><au>Mehmood, Kiran</au><au>Gaur, Namrata</au><au>Tandon, Rohit</au><au>Moorthy, Asha</au><au>George, Sheeba</au><au>Katyal, V K</au><au>Mantri, R R</au><au>Mehrotra, Rahul</au><au>Bhalla, Dilip</au><au>Mittal, Vinod</au><au>Rao, Sarita</au><au>Jagia, Manish</au><au>Singh, Harmeet</au><au>Awasthi, Surabhi</au><au>Sattur, Ameet</au><au>Mishra, Rekha</au><au>Pandey, Anand</au><au>Chawla, Rajeev</au><au>Jaggi, Shalini</au><au>Sehgal, Blessy</au><au>Sehgal, Alok</au><au>Goel, Naresh</au><au>Gupta, Ripen</au><au>Kubba, Samir</au><au>Chhabra, Abhinav</au><au>Bagga, Saurabh</au><au>Shastry, N R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current Place of SGLT2i in the Management of Heart Failure: An Expert Opinion from India</atitle><jtitle>Journal of the Association of Physicians of India</jtitle><addtitle>J Assoc Physicians India</addtitle><date>2024-01</date><risdate>2024</risdate><volume>72</volume><issue>1</issue><spage>63</spage><pages>63-</pages><issn>0004-5772</issn><abstract>Heart failure (HF) is a global health concern that is prevalent in India as well. HF is reported at a younger age in Indian patients with comorbidity of type 2 diabetes (T2DM) in approximately 50% of patients. Sodium-glucose cotransporter-2 inhibitors (SGLT2i), originally approved for T2DM, are new guideline-recommended and approved treatment strategies for HF. Extensive evidence highlights that SGLT2i exhibits profound cardiovascular (CV) benefits beyond glycemic control. SGLT2i, in conjunction with other guideline-directed medical therapies (GMDT), has additive effects in improving heart function and reducing adverse HF outcomes. The benefits of SGLT2i are across a spectrum of patients, with and without diabetes, suggesting their potential place in broader HF populations irrespective of ejection fraction (EF). This consensus builds on the updated evidence of the efficacy and safety of SGLT2i in HF and recommends its place in therapy with a focus on Indian patients with HF.</abstract><cop>India</cop><pmid>38736076</pmid><doi>10.59556/japi.71.0440</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0004-5772 |
| ispartof | Journal of the Association of Physicians of India, 2024-01, Vol.72 (1), p.63 |
| issn | 0004-5772 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3054433137 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - drug therapy Heart Failure - drug therapy Humans India Sodium-Glucose Transporter 2 Inhibitors - therapeutic use |
| title | Current Place of SGLT2i in the Management of Heart Failure: An Expert Opinion from India |
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