A Targeted Deep Sequencing Method to Quantify Endogenous Retrovirus Gag Sequence Variants and Open Reading Frames Expressed in Nonobese Diabetic Mice

Endogenous retroviruses (ERVs) are involved in autoimmune diseases such as type 1 diabetes (T1D). ERV gene products homologous to murine leukemia retroviruses are expressed in the pancreatic islets of NOD mice, a model of T1D. One ERV gene, Gag, with partial or complete open reading frames (ORFs), i...

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Veröffentlicht in:	The Journal of immunology (1950) 2024-07, Vol.213 (1), p.15-22
Hauptverfasser:	Dai, Yang D, Du, Wenge, Wang, Yaqin, Hu, Wen-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diabetes Mellitus, Type 1 - genetics Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - virology Endogenous Retroviruses - genetics Female Gene Products, gag - genetics High-Throughput Nucleotide Sequencing - methods Islets of Langerhans Mice Mice, Inbred NOD Open Reading Frames - genetics
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