ortho-Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes

ortho-Alkynyl Benzyl Alcohols as C6 Synthons in Regioselective Construction of Polysubstituted Naphthalenes

A straightforward methodology for the assembly of polysubstituted naphthalenes from ortho-alkynyl benzyl alcohols, enabled by using catalytic amounts of Tf2O, has been developed. This transformation not only features transition-metal free and without using other bases and additives but also provides...

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Veröffentlicht in:Journal of organic chemistry 2024-05, Vol.89 (11), p.7804-7811
Hauptverfasser: Wei, Xuemei, Cai, Tao, Zhang, Zhebing, Luo, Yanjuan, Shang, Tianbo, Shen, Hualiang, Xu, Huiting, Yu, Lemao, Luo, Xiang, Yu, Guoqi, Shen, Runpu
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Sprache:eng
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Zusammenfassung:A straightforward methodology for the assembly of polysubstituted naphthalenes from ortho-alkynyl benzyl alcohols, enabled by using catalytic amounts of Tf2O, has been developed. This transformation not only features transition-metal free and without using other bases and additives but also provides a new synthetic application for ortho-alkynyl benzyl alcohols, i.e., as C6 synthons for the construction of PAHs.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.4c00491