Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics
Purpose To characterize the dependence of Xe‐MRI gas transfer metrics upon age, sex, and lung volume in a group of healthy volunteers. Methods Sixty‐five subjects with no history of chronic lung disease were assessed with 129Xe‐MRI using a four‐echo 3D radial spectroscopic imaging sequence and a dos...
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| Veröffentlicht in: | Magnetic resonance in medicine 2024-10, Vol.92 (4), p.1471-1483 |
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| container_title | Magnetic resonance in medicine |
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| creator | Collier, Guilhem J. Smith, Laurie J. Saunders, Laura C. Swift, Andrew J. Marshall, Helen Stewart, Neil J. Norquay, Graham Hughes, Paul J. C. Thomspson, A. A. Roger Wild, Jim M. |
| description | Purpose
To characterize the dependence of Xe‐MRI gas transfer metrics upon age, sex, and lung volume in a group of healthy volunteers.
Methods
Sixty‐five subjects with no history of chronic lung disease were assessed with 129Xe‐MRI using a four‐echo 3D radial spectroscopic imaging sequence and a dose of xenon titrated according to subject height that was inhaled from a lung volume of functional residual capacity (FRC). Imaging was repeated in 34 subjects at total lung capacity (TLC). Regional maps of the fractions of dissolved xenon in red blood cells (RBC), membrane (M), and airspace (Gas) were acquired at an isotropic resolution of 2 cm, from which global averages of the ratios RBC:M, RBC:Gas, and M:Gas were computed.
Results
Data from 26 males and 36 females with a median age of 43 y (range: 20–69 y) were of sufficient quality to analyze. Age (p = 0.0006) and sex (p |
| doi_str_mv | 10.1002/mrm.30133 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3053981660</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3083077686</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3483-90abc579f7ac59a360042a5a799c6529ba99a33dc8d5c1af58d39a9f8cd9c99f3</originalsourceid><addsrcrecordid>eNp10MtKw0AUxvFBFFsvC19ABtwoGJ1LJpOzlOKl0CKIug3TmZOakkxqxmi78xF8Rp_EaNWF4Gpg-PHn8BGyx9kJZ0ycVk11IhmXco30uRIiEgriddJnOmaR5BD3yFYIM8YYgI43SU-mWiSxFn1yfzbFYxpwcUyNd7Rs_ZQ-12VbIXU4R-_QW6R1Tl0RQl0-o6ML9LV_f33jAuj4ZkinJlBc2Afjp0grfGoKG3bIRm7KgLvf7za5uzi_HVxFo-vL4eBsFFkZpzICZiZWaci1sQqMTBiLhVFGA9hECZgY6H6ls6lTlptcpU6CgTy1DixALrfJ4ao7b-rHFsNTVhXBYlkaj3UbMsmUhJQnCevowR86q9vGd9d1KpVM6yRNOnW0UrapQ2gwz-ZNUZlmmXGWfY6ddWNnX2N3dv-72E4qdL_yZ90OnK7AS1Hi8v9SNr4Zr5IfrT-Hug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3083077686</pqid></control><display><type>article</type><title>Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Collier, Guilhem J. ; Smith, Laurie J. ; Saunders, Laura C. ; Swift, Andrew J. ; Marshall, Helen ; Stewart, Neil J. ; Norquay, Graham ; Hughes, Paul J. C. ; Thomspson, A. A. Roger ; Wild, Jim M.</creator><creatorcontrib>Collier, Guilhem J. ; Smith, Laurie J. ; Saunders, Laura C. ; Swift, Andrew J. ; Marshall, Helen ; Stewart, Neil J. ; Norquay, Graham ; Hughes, Paul J. C. ; Thomspson, A. A. Roger ; Wild, Jim M.</creatorcontrib><description>Purpose
To characterize the dependence of Xe‐MRI gas transfer metrics upon age, sex, and lung volume in a group of healthy volunteers.
Methods
Sixty‐five subjects with no history of chronic lung disease were assessed with 129Xe‐MRI using a four‐echo 3D radial spectroscopic imaging sequence and a dose of xenon titrated according to subject height that was inhaled from a lung volume of functional residual capacity (FRC). Imaging was repeated in 34 subjects at total lung capacity (TLC). Regional maps of the fractions of dissolved xenon in red blood cells (RBC), membrane (M), and airspace (Gas) were acquired at an isotropic resolution of 2 cm, from which global averages of the ratios RBC:M, RBC:Gas, and M:Gas were computed.
Results
Data from 26 males and 36 females with a median age of 43 y (range: 20–69 y) were of sufficient quality to analyze. Age (p = 0.0006) and sex (p < 0.0001) were significant predictors for RBC:M, and a linear regression showed higher values and steeper decline in males: RBC:M(Males) = −0.00362 × Age + 0.60 (p = 0.01, R2 = 0.25); RBC:M(Females) = −0.00170 × Age + 0.44 (p = 0.02, R2 = 0.15). Similarly, age and sex were significant predictors for RBC:Gas but not for M:Gas. RBC:M, M:Gas and RBC:Gas were significantly lower at TLC than at FRC (plus inhaled volume), with an average 9%, 30% and 35% decrease, respectively.
Conclusion
Expected age and sex dependence of pulmonary function concurs with 129Xe RBC:M imaging results, demonstrating that these variables must be considered when reporting Xe‐MRI metrics. Xenon doses and breathing maneuvers should be controlled due to the strong dependence of Xe‐MRI metrics upon lung volume.</description><identifier>ISSN: 0740-3194</identifier><identifier>ISSN: 1522-2594</identifier><identifier>EISSN: 1522-2594</identifier><identifier>DOI: 10.1002/mrm.30133</identifier><identifier>PMID: 38726472</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age ; Age Factors ; Aged ; ageing ; Erythrocytes ; Female ; Females ; Functional magnetic resonance imaging ; Gas exchange ; Humans ; hyperpolarized 129Xe ; lung ; Lung - diagnostic imaging ; Lung diseases ; lung volume ; Lung Volume Measurements ; Magnetic Resonance Imaging - methods ; Male ; Males ; Medical imaging ; Middle Aged ; Pulmonary functions ; Pulmonary Gas Exchange ; Respiratory function ; Sex ; Sex Factors ; spectroscopic imaging ; Xenon ; Xenon 129 ; Xenon Isotopes ; Young Adult</subject><ispartof>Magnetic resonance in medicine, 2024-10, Vol.92 (4), p.1471-1483</ispartof><rights>2024 The Authors. published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2024 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3483-90abc579f7ac59a360042a5a799c6529ba99a33dc8d5c1af58d39a9f8cd9c99f3</cites><orcidid>0000-0002-1080-9861 ; 0000-0002-7979-5840 ; 0000-0002-1874-4775 ; 0000-0002-4108-9035 ; 0000-0001-8358-394X ; 0000-0002-0717-4551</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmrm.30133$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmrm.30133$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38726472$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collier, Guilhem J.</creatorcontrib><creatorcontrib>Smith, Laurie J.</creatorcontrib><creatorcontrib>Saunders, Laura C.</creatorcontrib><creatorcontrib>Swift, Andrew J.</creatorcontrib><creatorcontrib>Marshall, Helen</creatorcontrib><creatorcontrib>Stewart, Neil J.</creatorcontrib><creatorcontrib>Norquay, Graham</creatorcontrib><creatorcontrib>Hughes, Paul J. C.</creatorcontrib><creatorcontrib>Thomspson, A. A. Roger</creatorcontrib><creatorcontrib>Wild, Jim M.</creatorcontrib><title>Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics</title><title>Magnetic resonance in medicine</title><addtitle>Magn Reson Med</addtitle><description>Purpose
To characterize the dependence of Xe‐MRI gas transfer metrics upon age, sex, and lung volume in a group of healthy volunteers.
Methods
Sixty‐five subjects with no history of chronic lung disease were assessed with 129Xe‐MRI using a four‐echo 3D radial spectroscopic imaging sequence and a dose of xenon titrated according to subject height that was inhaled from a lung volume of functional residual capacity (FRC). Imaging was repeated in 34 subjects at total lung capacity (TLC). Regional maps of the fractions of dissolved xenon in red blood cells (RBC), membrane (M), and airspace (Gas) were acquired at an isotropic resolution of 2 cm, from which global averages of the ratios RBC:M, RBC:Gas, and M:Gas were computed.
Results
Data from 26 males and 36 females with a median age of 43 y (range: 20–69 y) were of sufficient quality to analyze. Age (p = 0.0006) and sex (p < 0.0001) were significant predictors for RBC:M, and a linear regression showed higher values and steeper decline in males: RBC:M(Males) = −0.00362 × Age + 0.60 (p = 0.01, R2 = 0.25); RBC:M(Females) = −0.00170 × Age + 0.44 (p = 0.02, R2 = 0.15). Similarly, age and sex were significant predictors for RBC:Gas but not for M:Gas. RBC:M, M:Gas and RBC:Gas were significantly lower at TLC than at FRC (plus inhaled volume), with an average 9%, 30% and 35% decrease, respectively.
Conclusion
Expected age and sex dependence of pulmonary function concurs with 129Xe RBC:M imaging results, demonstrating that these variables must be considered when reporting Xe‐MRI metrics. Xenon doses and breathing maneuvers should be controlled due to the strong dependence of Xe‐MRI metrics upon lung volume.</description><subject>Adult</subject><subject>Age</subject><subject>Age Factors</subject><subject>Aged</subject><subject>ageing</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Females</subject><subject>Functional magnetic resonance imaging</subject><subject>Gas exchange</subject><subject>Humans</subject><subject>hyperpolarized 129Xe</subject><subject>lung</subject><subject>Lung - diagnostic imaging</subject><subject>Lung diseases</subject><subject>lung volume</subject><subject>Lung Volume Measurements</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Males</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Pulmonary functions</subject><subject>Pulmonary Gas Exchange</subject><subject>Respiratory function</subject><subject>Sex</subject><subject>Sex Factors</subject><subject>spectroscopic imaging</subject><subject>Xenon</subject><subject>Xenon 129</subject><subject>Xenon Isotopes</subject><subject>Young Adult</subject><issn>0740-3194</issn><issn>1522-2594</issn><issn>1522-2594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp10MtKw0AUxvFBFFsvC19ABtwoGJ1LJpOzlOKl0CKIug3TmZOakkxqxmi78xF8Rp_EaNWF4Gpg-PHn8BGyx9kJZ0ycVk11IhmXco30uRIiEgriddJnOmaR5BD3yFYIM8YYgI43SU-mWiSxFn1yfzbFYxpwcUyNd7Rs_ZQ-12VbIXU4R-_QW6R1Tl0RQl0-o6ML9LV_f33jAuj4ZkinJlBc2Afjp0grfGoKG3bIRm7KgLvf7za5uzi_HVxFo-vL4eBsFFkZpzICZiZWaci1sQqMTBiLhVFGA9hECZgY6H6ls6lTlptcpU6CgTy1DixALrfJ4ao7b-rHFsNTVhXBYlkaj3UbMsmUhJQnCevowR86q9vGd9d1KpVM6yRNOnW0UrapQ2gwz-ZNUZlmmXGWfY6ddWNnX2N3dv-72E4qdL_yZ90OnK7AS1Hi8v9SNr4Zr5IfrT-Hug</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Collier, Guilhem J.</creator><creator>Smith, Laurie J.</creator><creator>Saunders, Laura C.</creator><creator>Swift, Andrew J.</creator><creator>Marshall, Helen</creator><creator>Stewart, Neil J.</creator><creator>Norquay, Graham</creator><creator>Hughes, Paul J. C.</creator><creator>Thomspson, A. A. Roger</creator><creator>Wild, Jim M.</creator><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1080-9861</orcidid><orcidid>https://orcid.org/0000-0002-7979-5840</orcidid><orcidid>https://orcid.org/0000-0002-1874-4775</orcidid><orcidid>https://orcid.org/0000-0002-4108-9035</orcidid><orcidid>https://orcid.org/0000-0001-8358-394X</orcidid><orcidid>https://orcid.org/0000-0002-0717-4551</orcidid></search><sort><creationdate>202410</creationdate><title>Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics</title><author>Collier, Guilhem J. ; Smith, Laurie J. ; Saunders, Laura C. ; Swift, Andrew J. ; Marshall, Helen ; Stewart, Neil J. ; Norquay, Graham ; Hughes, Paul J. C. ; Thomspson, A. A. Roger ; Wild, Jim M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3483-90abc579f7ac59a360042a5a799c6529ba99a33dc8d5c1af58d39a9f8cd9c99f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Age</topic><topic>Age Factors</topic><topic>Aged</topic><topic>ageing</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Females</topic><topic>Functional magnetic resonance imaging</topic><topic>Gas exchange</topic><topic>Humans</topic><topic>hyperpolarized 129Xe</topic><topic>lung</topic><topic>Lung - diagnostic imaging</topic><topic>Lung diseases</topic><topic>lung volume</topic><topic>Lung Volume Measurements</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Males</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Pulmonary functions</topic><topic>Pulmonary Gas Exchange</topic><topic>Respiratory function</topic><topic>Sex</topic><topic>Sex Factors</topic><topic>spectroscopic imaging</topic><topic>Xenon</topic><topic>Xenon 129</topic><topic>Xenon Isotopes</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collier, Guilhem J.</creatorcontrib><creatorcontrib>Smith, Laurie J.</creatorcontrib><creatorcontrib>Saunders, Laura C.</creatorcontrib><creatorcontrib>Swift, Andrew J.</creatorcontrib><creatorcontrib>Marshall, Helen</creatorcontrib><creatorcontrib>Stewart, Neil J.</creatorcontrib><creatorcontrib>Norquay, Graham</creatorcontrib><creatorcontrib>Hughes, Paul J. C.</creatorcontrib><creatorcontrib>Thomspson, A. A. Roger</creatorcontrib><creatorcontrib>Wild, Jim M.</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Magnetic resonance in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collier, Guilhem J.</au><au>Smith, Laurie J.</au><au>Saunders, Laura C.</au><au>Swift, Andrew J.</au><au>Marshall, Helen</au><au>Stewart, Neil J.</au><au>Norquay, Graham</au><au>Hughes, Paul J. C.</au><au>Thomspson, A. A. Roger</au><au>Wild, Jim M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics</atitle><jtitle>Magnetic resonance in medicine</jtitle><addtitle>Magn Reson Med</addtitle><date>2024-10</date><risdate>2024</risdate><volume>92</volume><issue>4</issue><spage>1471</spage><epage>1483</epage><pages>1471-1483</pages><issn>0740-3194</issn><issn>1522-2594</issn><eissn>1522-2594</eissn><abstract>Purpose
To characterize the dependence of Xe‐MRI gas transfer metrics upon age, sex, and lung volume in a group of healthy volunteers.
Methods
Sixty‐five subjects with no history of chronic lung disease were assessed with 129Xe‐MRI using a four‐echo 3D radial spectroscopic imaging sequence and a dose of xenon titrated according to subject height that was inhaled from a lung volume of functional residual capacity (FRC). Imaging was repeated in 34 subjects at total lung capacity (TLC). Regional maps of the fractions of dissolved xenon in red blood cells (RBC), membrane (M), and airspace (Gas) were acquired at an isotropic resolution of 2 cm, from which global averages of the ratios RBC:M, RBC:Gas, and M:Gas were computed.
Results
Data from 26 males and 36 females with a median age of 43 y (range: 20–69 y) were of sufficient quality to analyze. Age (p = 0.0006) and sex (p < 0.0001) were significant predictors for RBC:M, and a linear regression showed higher values and steeper decline in males: RBC:M(Males) = −0.00362 × Age + 0.60 (p = 0.01, R2 = 0.25); RBC:M(Females) = −0.00170 × Age + 0.44 (p = 0.02, R2 = 0.15). Similarly, age and sex were significant predictors for RBC:Gas but not for M:Gas. RBC:M, M:Gas and RBC:Gas were significantly lower at TLC than at FRC (plus inhaled volume), with an average 9%, 30% and 35% decrease, respectively.
Conclusion
Expected age and sex dependence of pulmonary function concurs with 129Xe RBC:M imaging results, demonstrating that these variables must be considered when reporting Xe‐MRI metrics. Xenon doses and breathing maneuvers should be controlled due to the strong dependence of Xe‐MRI metrics upon lung volume.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38726472</pmid><doi>10.1002/mrm.30133</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-1080-9861</orcidid><orcidid>https://orcid.org/0000-0002-7979-5840</orcidid><orcidid>https://orcid.org/0000-0002-1874-4775</orcidid><orcidid>https://orcid.org/0000-0002-4108-9035</orcidid><orcidid>https://orcid.org/0000-0001-8358-394X</orcidid><orcidid>https://orcid.org/0000-0002-0717-4551</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Age Factors Aged ageing Erythrocytes Female Females Functional magnetic resonance imaging Gas exchange Humans hyperpolarized 129Xe lung Lung - diagnostic imaging Lung diseases lung volume Lung Volume Measurements Magnetic Resonance Imaging - methods Male Males Medical imaging Middle Aged Pulmonary functions Pulmonary Gas Exchange Respiratory function Sex Sex Factors spectroscopic imaging Xenon Xenon 129 Xenon Isotopes Young Adult |
| title | Age, sex, and lung volume dependence of dissolved xenon‐129 MRI gas exchange metrics |
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