Upregulation of HAS2 promotes glioma cell proliferation and chemoresistance via c-myc

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant human brain tumor. Although comprehensive therapies, including chemotherapy and radiotherapy following surgery, have shown promise in prolonging survival, the prognosis for GBM patients remains poor, with an overall su...

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Veröffentlicht in:	Cellular signalling 2024-08, Vol.120, p.111218, Article 111218
Hauptverfasser:	Wang, Juling, Ruan, Shengming, Yu, Tengfei, Meng, Xiaoxiao, Ran, Juan, Cen, Chaozhu, Kong, Chuifang, Bao, Xunxia, Li, Zhenzhen, Wang, Yi, Ren, Mengfei, Guo, Pin, Teng, Yanbin, Zhang, Daoxiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology C-myc Cell Line, Tumor Cell Proliferation Chemoresistance Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Neoplastic Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioma Glioma - genetics Glioma - metabolism Glioma - pathology Has2 Humans Hyaluronan Synthases - genetics Hyaluronan Synthases - metabolism Hyaluronic Acid - metabolism Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Mice Mice, Nude Proto-Oncogene Proteins c-myc - metabolism Up-Regulation
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