A new G3BP1-GFP reporter system for assessing skin toxicity by real-time monitoring of stress granules in vitro

The skin, the organ with the largest surface area in the body, is the most susceptible to chemical exposure from the external environment. In this study, we aimed to establish an in vitro skin toxicity monitoring system that utilizes the mechanism of stress granule (SG) formation induced by various...

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Veröffentlicht in:	Toxicology letters 2024-06, Vol.397, p.48-54
Hauptverfasser:	Kwon, Eunhye, Jung, Da-Min, Kim, Eun-Mi, Kim, Kee K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arsenites - toxicity Benzalkonium chloride Benzhydryl Compounds - toxicity Bisphenol-A Cytoplasmic Granules - drug effects Cytoplasmic Granules - metabolism DNA Helicases - genetics DNA Helicases - metabolism Eukaryotic Initiation Factor-2 - genetics Eukaryotic Initiation Factor-2 - metabolism G3BP1 Gene Knock-In Techniques Genes, Reporter - drug effects Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism HaCaT HaCaT Cells Humans Keratinocytes - drug effects Keratinocytes - metabolism Phenols - toxicity Phosphorylation Poly-ADP-Ribose Binding Proteins - genetics Poly-ADP-Ribose Binding Proteins - metabolism RNA Helicases - genetics RNA Helicases - metabolism RNA Recognition Motif Proteins - genetics RNA Recognition Motif Proteins - metabolism Skin - drug effects Skin - metabolism Skin toxicity Stress granules Toxicity Tests - methods
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