Utility of sulfachloropyridazine in the synthesis of novel anticancer agents as antiangiogenic and apoptotic inducers

[Display omitted] •Synthesis of thiourea and thiocarbamate derivatives bearing sulfachloropyridazine.•Compounds were screened for cytotoxicity against a panel of 60 cell lines.•VEGFR-2 inhibitory activity was evaluated for promising compounds.•Apoptotic study and cell cycle effect were conducted for...

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Veröffentlicht in:	Bioorganic chemistry 2024-07, Vol.148, p.107411-107411, Article 107411
Hauptverfasser:	Zahran, Sally S., Ragab, Fatma A., Soliman, Aiten M., El-Gazzar, Marwa G., Mahmoud, Walaa R., Ghorab, Mostafa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Angiogenesis Inhibitors - chemical synthesis Angiogenesis Inhibitors - chemistry Angiogenesis Inhibitors - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Apoptosis Apoptosis - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Humans Molecular Docking Simulation Molecular Structure Pyridazines - chemical synthesis Pyridazines - chemistry Pyridazines - pharmacology Structure-Activity Relationship Sulfachloropyridazine Thiocarbamates Thiourea Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGFR-2
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