Robotic-arm assisted versus manual total knee arthroplasty: Functional gait analysis from a randomised controlled trial

The primary aim of this study was to assess whether measures of functional gait assessment were improved with robotic total knee arthroplasty (rTKA) when compared to manual TKA (mTKA). Gait analysis was performed as part of a randomised controlled trial. Walking and relaxed standing assessments were...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of biomechanics 2024-05, Vol.169, p.112112-112112, Article 112112
Hauptverfasser: Ajekigbe, Bola, Ramaskandhan, Jayasree, Clement, Nick, Galloway, Steven, Gabrov, Natasha, Smith, Karen, Weir, David, Deehan, David
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 112112
container_issue
container_start_page 112112
container_title Journal of biomechanics
container_volume 169
creator Ajekigbe, Bola
Ramaskandhan, Jayasree
Clement, Nick
Galloway, Steven
Gabrov, Natasha
Smith, Karen
Weir, David
Deehan, David
description The primary aim of this study was to assess whether measures of functional gait assessment were improved with robotic total knee arthroplasty (rTKA) when compared to manual TKA (mTKA). Gait analysis was performed as part of a randomised controlled trial. Walking and relaxed standing assessments were performed using an instrumented mat system. Spatiotemporal variables included gait cycle parameters, anteroposterior and lateral sway, and plantar pressure ratios. Measurements were recorded at pre-operative baseline and 12 months post-operatively. 100 patients were randomised, 50 to each group. Complete gait cycle data were available for 26 rTKA and 23 mTKA patients. Cadence and walking velocity showed overall improvements following surgery, with no difference between the two groups. In the operated limb, overall step and stride times decreased, while step and stride lengths increased. Subgroup analysis showed reduced propulsion time with rTKA, and decreased foot flat and mid stance times with mTKA. Lateral sway was decreased in the rTKA group. Plantar pressure ratios showed an overall increase in hindfoot loading on the operated limb, with no difference between the two groups. No other significant differences were identified between rTKA and mTKA at 12 months, and limitations may include statistical error. A small sample of the study cohort was followed up; analysis may represent the results of satisfied patients with well-functioning TKA. Further study could incorporate proprioceptive and 3D gait analysis techniques to analyse knee kinetics and kinematics with robotic surgery. Pressure mapping could further subdivide the plantar surfaces to explore any nuances in differential loading.
doi_str_mv 10.1016/j.jbiomech.2024.112112
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3053979413</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0021929024001908</els_id><sourcerecordid>3053979413</sourcerecordid><originalsourceid>FETCH-LOGICAL-c343t-5f17c8ea6e744b12e1fb5f27e2a5b504510a276b7db2fe478f3bdbcb13c2e1553</originalsourceid><addsrcrecordid>eNqFkU9rFTEUxYNY7LP6FUrAjZt55u_LjCulWBUKQmnXIcncsRlnJs8kU3nf3ltf68KNEJIL-d1zk3MIOedsyxnfvRu3o49phnC3FUyoLecC1zOy4a2RjZAte042jAnedKJjp-RlKSNjzCjTvSCnsjVCKi435Nd18qnG0Lg8U1dKLBV6eg-5rIXOblndRGuquP9YAKjL9S6n_eRKPbynl-sSakwL3n53sVKH1QEl6JATqtHslj7NsaBiSEvNaZqwrDm66RU5GdxU4PXjeUZuLz_dXHxprr59_nrx8aoJUsna6IGb0ILbgVHKcwF88HoQBoTTXjOlOXPC7LzpvRhAmXaQvvfBcxmQ1VqekbdH3X1OP1co1eJ7AkyTWyCtxUqmZWc69ALRN_-gY1ozfukP1Qmt0GKkdkcq5FRKhsHuc5xdPljO7EM0drRP0diHaOwxGmw8f5Rf_Qz937anLBD4cAQA_biPkG0JEZYAfcwQqu1T_N-M33TUpL4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3059254211</pqid></control><display><type>article</type><title>Robotic-arm assisted versus manual total knee arthroplasty: Functional gait analysis from a randomised controlled trial</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Ajekigbe, Bola ; Ramaskandhan, Jayasree ; Clement, Nick ; Galloway, Steven ; Gabrov, Natasha ; Smith, Karen ; Weir, David ; Deehan, David</creator><creatorcontrib>Ajekigbe, Bola ; Ramaskandhan, Jayasree ; Clement, Nick ; Galloway, Steven ; Gabrov, Natasha ; Smith, Karen ; Weir, David ; Deehan, David</creatorcontrib><description>The primary aim of this study was to assess whether measures of functional gait assessment were improved with robotic total knee arthroplasty (rTKA) when compared to manual TKA (mTKA). Gait analysis was performed as part of a randomised controlled trial. Walking and relaxed standing assessments were performed using an instrumented mat system. Spatiotemporal variables included gait cycle parameters, anteroposterior and lateral sway, and plantar pressure ratios. Measurements were recorded at pre-operative baseline and 12 months post-operatively. 100 patients were randomised, 50 to each group. Complete gait cycle data were available for 26 rTKA and 23 mTKA patients. Cadence and walking velocity showed overall improvements following surgery, with no difference between the two groups. In the operated limb, overall step and stride times decreased, while step and stride lengths increased. Subgroup analysis showed reduced propulsion time with rTKA, and decreased foot flat and mid stance times with mTKA. Lateral sway was decreased in the rTKA group. Plantar pressure ratios showed an overall increase in hindfoot loading on the operated limb, with no difference between the two groups. No other significant differences were identified between rTKA and mTKA at 12 months, and limitations may include statistical error. A small sample of the study cohort was followed up; analysis may represent the results of satisfied patients with well-functioning TKA. Further study could incorporate proprioceptive and 3D gait analysis techniques to analyse knee kinetics and kinematics with robotic surgery. Pressure mapping could further subdivide the plantar surfaces to explore any nuances in differential loading.</description><identifier>ISSN: 0021-9290</identifier><identifier>EISSN: 1873-2380</identifier><identifier>DOI: 10.1016/j.jbiomech.2024.112112</identifier><identifier>PMID: 38723413</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Aged ; Arthritis ; Arthroplasty ; Arthroplasty (knee) ; Arthroplasty, Replacement, Knee - methods ; Biomechanical Phenomena ; Contingency tables ; Data analysis ; Error analysis ; Female ; Gait ; Gait - physiology ; Gait analysis ; Gait Analysis - methods ; Humans ; Joint replacement surgery ; Kinematics ; Knee ; Knee Joint - physiopathology ; Knee Joint - surgery ; Male ; Medical imaging ; Middle Aged ; Orthopaedic implants ; Osteoarthritis ; Pandemics ; Patients ; Plantar pressure ; Proprioception ; Robotic ; Robotic surgery ; Robotic Surgical Procedures - methods ; Robotics ; Subgroups ; Surgeons ; Velocity ; Walking</subject><ispartof>Journal of biomechanics, 2024-05, Vol.169, p.112112-112112, Article 112112</ispartof><rights>2024</rights><rights>Crown Copyright © 2024. Published by Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited May 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c343t-5f17c8ea6e744b12e1fb5f27e2a5b504510a276b7db2fe478f3bdbcb13c2e1553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0021929024001908$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38723413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ajekigbe, Bola</creatorcontrib><creatorcontrib>Ramaskandhan, Jayasree</creatorcontrib><creatorcontrib>Clement, Nick</creatorcontrib><creatorcontrib>Galloway, Steven</creatorcontrib><creatorcontrib>Gabrov, Natasha</creatorcontrib><creatorcontrib>Smith, Karen</creatorcontrib><creatorcontrib>Weir, David</creatorcontrib><creatorcontrib>Deehan, David</creatorcontrib><title>Robotic-arm assisted versus manual total knee arthroplasty: Functional gait analysis from a randomised controlled trial</title><title>Journal of biomechanics</title><addtitle>J Biomech</addtitle><description>The primary aim of this study was to assess whether measures of functional gait assessment were improved with robotic total knee arthroplasty (rTKA) when compared to manual TKA (mTKA). Gait analysis was performed as part of a randomised controlled trial. Walking and relaxed standing assessments were performed using an instrumented mat system. Spatiotemporal variables included gait cycle parameters, anteroposterior and lateral sway, and plantar pressure ratios. Measurements were recorded at pre-operative baseline and 12 months post-operatively. 100 patients were randomised, 50 to each group. Complete gait cycle data were available for 26 rTKA and 23 mTKA patients. Cadence and walking velocity showed overall improvements following surgery, with no difference between the two groups. In the operated limb, overall step and stride times decreased, while step and stride lengths increased. Subgroup analysis showed reduced propulsion time with rTKA, and decreased foot flat and mid stance times with mTKA. Lateral sway was decreased in the rTKA group. Plantar pressure ratios showed an overall increase in hindfoot loading on the operated limb, with no difference between the two groups. No other significant differences were identified between rTKA and mTKA at 12 months, and limitations may include statistical error. A small sample of the study cohort was followed up; analysis may represent the results of satisfied patients with well-functioning TKA. Further study could incorporate proprioceptive and 3D gait analysis techniques to analyse knee kinetics and kinematics with robotic surgery. Pressure mapping could further subdivide the plantar surfaces to explore any nuances in differential loading.</description><subject>Aged</subject><subject>Arthritis</subject><subject>Arthroplasty</subject><subject>Arthroplasty (knee)</subject><subject>Arthroplasty, Replacement, Knee - methods</subject><subject>Biomechanical Phenomena</subject><subject>Contingency tables</subject><subject>Data analysis</subject><subject>Error analysis</subject><subject>Female</subject><subject>Gait</subject><subject>Gait - physiology</subject><subject>Gait analysis</subject><subject>Gait Analysis - methods</subject><subject>Humans</subject><subject>Joint replacement surgery</subject><subject>Kinematics</subject><subject>Knee</subject><subject>Knee Joint - physiopathology</subject><subject>Knee Joint - surgery</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Orthopaedic implants</subject><subject>Osteoarthritis</subject><subject>Pandemics</subject><subject>Patients</subject><subject>Plantar pressure</subject><subject>Proprioception</subject><subject>Robotic</subject><subject>Robotic surgery</subject><subject>Robotic Surgical Procedures - methods</subject><subject>Robotics</subject><subject>Subgroups</subject><subject>Surgeons</subject><subject>Velocity</subject><subject>Walking</subject><issn>0021-9290</issn><issn>1873-2380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU9rFTEUxYNY7LP6FUrAjZt55u_LjCulWBUKQmnXIcncsRlnJs8kU3nf3ltf68KNEJIL-d1zk3MIOedsyxnfvRu3o49phnC3FUyoLecC1zOy4a2RjZAte042jAnedKJjp-RlKSNjzCjTvSCnsjVCKi435Nd18qnG0Lg8U1dKLBV6eg-5rIXOblndRGuquP9YAKjL9S6n_eRKPbynl-sSakwL3n53sVKH1QEl6JATqtHslj7NsaBiSEvNaZqwrDm66RU5GdxU4PXjeUZuLz_dXHxprr59_nrx8aoJUsna6IGb0ILbgVHKcwF88HoQBoTTXjOlOXPC7LzpvRhAmXaQvvfBcxmQ1VqekbdH3X1OP1co1eJ7AkyTWyCtxUqmZWc69ALRN_-gY1ozfukP1Qmt0GKkdkcq5FRKhsHuc5xdPljO7EM0drRP0diHaOwxGmw8f5Rf_Qz937anLBD4cAQA_biPkG0JEZYAfcwQqu1T_N-M33TUpL4</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Ajekigbe, Bola</creator><creator>Ramaskandhan, Jayasree</creator><creator>Clement, Nick</creator><creator>Galloway, Steven</creator><creator>Gabrov, Natasha</creator><creator>Smith, Karen</creator><creator>Weir, David</creator><creator>Deehan, David</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7TB</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>202405</creationdate><title>Robotic-arm assisted versus manual total knee arthroplasty: Functional gait analysis from a randomised controlled trial</title><author>Ajekigbe, Bola ; Ramaskandhan, Jayasree ; Clement, Nick ; Galloway, Steven ; Gabrov, Natasha ; Smith, Karen ; Weir, David ; Deehan, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c343t-5f17c8ea6e744b12e1fb5f27e2a5b504510a276b7db2fe478f3bdbcb13c2e1553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Arthritis</topic><topic>Arthroplasty</topic><topic>Arthroplasty (knee)</topic><topic>Arthroplasty, Replacement, Knee - methods</topic><topic>Biomechanical Phenomena</topic><topic>Contingency tables</topic><topic>Data analysis</topic><topic>Error analysis</topic><topic>Female</topic><topic>Gait</topic><topic>Gait - physiology</topic><topic>Gait analysis</topic><topic>Gait Analysis - methods</topic><topic>Humans</topic><topic>Joint replacement surgery</topic><topic>Kinematics</topic><topic>Knee</topic><topic>Knee Joint - physiopathology</topic><topic>Knee Joint - surgery</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Orthopaedic implants</topic><topic>Osteoarthritis</topic><topic>Pandemics</topic><topic>Patients</topic><topic>Plantar pressure</topic><topic>Proprioception</topic><topic>Robotic</topic><topic>Robotic surgery</topic><topic>Robotic Surgical Procedures - methods</topic><topic>Robotics</topic><topic>Subgroups</topic><topic>Surgeons</topic><topic>Velocity</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ajekigbe, Bola</creatorcontrib><creatorcontrib>Ramaskandhan, Jayasree</creatorcontrib><creatorcontrib>Clement, Nick</creatorcontrib><creatorcontrib>Galloway, Steven</creatorcontrib><creatorcontrib>Gabrov, Natasha</creatorcontrib><creatorcontrib>Smith, Karen</creatorcontrib><creatorcontrib>Weir, David</creatorcontrib><creatorcontrib>Deehan, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium &amp; Calcified Tissue Abstracts</collection><collection>Mechanical &amp; Transportation Engineering Abstracts</collection><collection>Physical Education Index</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of biomechanics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ajekigbe, Bola</au><au>Ramaskandhan, Jayasree</au><au>Clement, Nick</au><au>Galloway, Steven</au><au>Gabrov, Natasha</au><au>Smith, Karen</au><au>Weir, David</au><au>Deehan, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Robotic-arm assisted versus manual total knee arthroplasty: Functional gait analysis from a randomised controlled trial</atitle><jtitle>Journal of biomechanics</jtitle><addtitle>J Biomech</addtitle><date>2024-05</date><risdate>2024</risdate><volume>169</volume><spage>112112</spage><epage>112112</epage><pages>112112-112112</pages><artnum>112112</artnum><issn>0021-9290</issn><eissn>1873-2380</eissn><abstract>The primary aim of this study was to assess whether measures of functional gait assessment were improved with robotic total knee arthroplasty (rTKA) when compared to manual TKA (mTKA). Gait analysis was performed as part of a randomised controlled trial. Walking and relaxed standing assessments were performed using an instrumented mat system. Spatiotemporal variables included gait cycle parameters, anteroposterior and lateral sway, and plantar pressure ratios. Measurements were recorded at pre-operative baseline and 12 months post-operatively. 100 patients were randomised, 50 to each group. Complete gait cycle data were available for 26 rTKA and 23 mTKA patients. Cadence and walking velocity showed overall improvements following surgery, with no difference between the two groups. In the operated limb, overall step and stride times decreased, while step and stride lengths increased. Subgroup analysis showed reduced propulsion time with rTKA, and decreased foot flat and mid stance times with mTKA. Lateral sway was decreased in the rTKA group. Plantar pressure ratios showed an overall increase in hindfoot loading on the operated limb, with no difference between the two groups. No other significant differences were identified between rTKA and mTKA at 12 months, and limitations may include statistical error. A small sample of the study cohort was followed up; analysis may represent the results of satisfied patients with well-functioning TKA. Further study could incorporate proprioceptive and 3D gait analysis techniques to analyse knee kinetics and kinematics with robotic surgery. Pressure mapping could further subdivide the plantar surfaces to explore any nuances in differential loading.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>38723413</pmid><doi>10.1016/j.jbiomech.2024.112112</doi><tpages>1</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0021-9290
ispartof Journal of biomechanics, 2024-05, Vol.169, p.112112-112112, Article 112112
issn 0021-9290
1873-2380
language eng
recordid cdi_proquest_miscellaneous_3053979413
source MEDLINE; Elsevier ScienceDirect Journals
subjects Aged
Arthritis
Arthroplasty
Arthroplasty (knee)
Arthroplasty, Replacement, Knee - methods
Biomechanical Phenomena
Contingency tables
Data analysis
Error analysis
Female
Gait
Gait - physiology
Gait analysis
Gait Analysis - methods
Humans
Joint replacement surgery
Kinematics
Knee
Knee Joint - physiopathology
Knee Joint - surgery
Male
Medical imaging
Middle Aged
Orthopaedic implants
Osteoarthritis
Pandemics
Patients
Plantar pressure
Proprioception
Robotic
Robotic surgery
Robotic Surgical Procedures - methods
Robotics
Subgroups
Surgeons
Velocity
Walking
title Robotic-arm assisted versus manual total knee arthroplasty: Functional gait analysis from a randomised controlled trial
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A32%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Robotic-arm%20assisted%20versus%20manual%20total%20knee%20arthroplasty:%20Functional%20gait%20analysis%20from%20a%20randomised%20controlled%20trial&rft.jtitle=Journal%20of%20biomechanics&rft.au=Ajekigbe,%20Bola&rft.date=2024-05&rft.volume=169&rft.spage=112112&rft.epage=112112&rft.pages=112112-112112&rft.artnum=112112&rft.issn=0021-9290&rft.eissn=1873-2380&rft_id=info:doi/10.1016/j.jbiomech.2024.112112&rft_dat=%3Cproquest_cross%3E3053979413%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3059254211&rft_id=info:pmid/38723413&rft_els_id=S0021929024001908&rfr_iscdi=true