The effects of L-DOPA on gait abnormalities in a unilateral 6-OHDA rat model of Parkinson's disease

•Unilateral 6-OHDA lesion of the medial forebrain bundle induced stepping and gait deficits.•L-DOPA did not rescue gait deficits, but dose-dependently induced dyskinesia.•Post-mortem deficits in striatal dopamine and prefrontal cortex norepinephrine were associated with gait deficits. Parkinson'...

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Veröffentlicht in:	Physiology & behavior 2024-07, Vol.281, p.114563-114563, Article 114563
Hauptverfasser:	Holden, Hannah, Venkatesh, Shruti, Budrow, Carla, Nezaria, Sareen, Coyle, Michael, Centner, Ashley, Lipari, Natalie, McManus, Grace, Bishop, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiparkinson Agents - pharmacology CatWalk Disease Models, Animal Dopamine Dopamine - metabolism Dose-Response Relationship, Drug Dyskinesia, Drug-Induced Female Functional Laterality - drug effects Gait Gait - drug effects Gait Disorders, Neurologic - chemically induced Gait Disorders, Neurologic - drug therapy Gait Disorders, Neurologic - etiology L-DOPA-induced dyskinesia Levodopa - adverse effects Levodopa - pharmacology Male Medial Forebrain Bundle - drug effects Norepinephrine Oxidopamine Parkinson Disease - drug therapy Parkinson Disease - pathology Parkinson Disease - physiopathology Parkinson's disease Parkinsonian Disorders - chemically induced Parkinsonian Disorders - drug therapy Parkinsonian Disorders - pathology Parkinsonian Disorders - physiopathology Rats Rats, Sprague-Dawley
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