3D-Volumetric Shunt Measurement for Detection of High-Risk Esophageal Varices in Liver Cirrhosis
Esophageal varices (EV) and variceal hemorrhages are major causes of mortality in liver cirrhosis patients. Detecting EVs early is crucial for effective management. Computed tomography (CT) scans, commonly performed for various liver-related indications, provide an opportunity for non-invasive EV as...
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| Veröffentlicht in: | Journal of clinical medicine 2024-05, Vol.13 (9), p.2678 |
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| creator | Glückert, Kathleen Decker, Alexandra Meier, Jörn Arne Nowak, Sebastian Sanoubara, Feras Gödiker, Juliana Reinartz Groba, Sara Noemi Kimmann, Markus Luetkens, Julian A Chang, Johannes Sprinkart, Alois M Praktiknjo, Michael |
| description | Esophageal varices (EV) and variceal hemorrhages are major causes of mortality in liver cirrhosis patients. Detecting EVs early is crucial for effective management. Computed tomography (CT) scans, commonly performed for various liver-related indications, provide an opportunity for non-invasive EV assessment. However, previous CT studies focused on variceal diameter, neglecting the three-dimensional (3D) nature of varices and shunt vessels. This study aims to evaluate the potential of 3D volumetric shunt-vessel measurements from routine CT scans for detecting high-risk esophageal varices in portal hypertension.
3D volumetric measurements of esophageal varices were conducted using routine CT scans and compared to endoscopic variceal grading. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff value for identifying high-risk varices based on shunt volume. The study included 142 patients who underwent both esophagogastroduodenoscopy (EGD) and contrast-enhanced CT within six months.
The study established a cutoff value for identifying high-risk varices. The CT measurements exhibited a significant correlation with endoscopic EV grading (correlation coefficient r = 0.417,
< 0.001). A CT cutoff value of 2060 mm
for variceal volume showed a sensitivity of 72.1% and a specificity of 65.5% for detecting high-risk varices during endoscopy.
This study demonstrates the feasibility of opportunistically measuring variceal volumes from routine CT scans. CT volumetry for assessing EVs may have prognostic value, especially in cirrhosis patients who are not suitable candidates for endoscopy. |
| doi_str_mv | 10.3390/jcm13092678 |
| format | Article |
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3D volumetric measurements of esophageal varices were conducted using routine CT scans and compared to endoscopic variceal grading. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff value for identifying high-risk varices based on shunt volume. The study included 142 patients who underwent both esophagogastroduodenoscopy (EGD) and contrast-enhanced CT within six months.
The study established a cutoff value for identifying high-risk varices. The CT measurements exhibited a significant correlation with endoscopic EV grading (correlation coefficient r = 0.417,
< 0.001). A CT cutoff value of 2060 mm
for variceal volume showed a sensitivity of 72.1% and a specificity of 65.5% for detecting high-risk varices during endoscopy.
This study demonstrates the feasibility of opportunistically measuring variceal volumes from routine CT scans. CT volumetry for assessing EVs may have prognostic value, especially in cirrhosis patients who are not suitable candidates for endoscopy.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm13092678</identifier><identifier>PMID: 38731206</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Ascites ; Chronic diseases ; Chronic illnesses ; Complications and side effects ; CT imaging ; Development and progression ; Diagnosis ; Disease prevention ; Endoscopy ; Esophageal varices ; Esophagus ; Gastroenterology ; Health aspects ; Hospitals ; Hypertension ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Liver transplants ; Measurement ; Medical imaging ; Risk factors ; Tomography ; Ultrasonic imaging ; Varicose veins ; Volumetric analysis</subject><ispartof>Journal of clinical medicine, 2024-05, Vol.13 (9), p.2678</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c379t-86d3d094b8d1004ad2ba19d0bd7cacb3b9761d44036ef9df60da231bb362aaa23</cites><orcidid>0000-0002-1435-9562 ; 0000-0001-7033-9956 ; 0000-0002-7715-4636</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38731206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Glückert, Kathleen</creatorcontrib><creatorcontrib>Decker, Alexandra</creatorcontrib><creatorcontrib>Meier, Jörn Arne</creatorcontrib><creatorcontrib>Nowak, Sebastian</creatorcontrib><creatorcontrib>Sanoubara, Feras</creatorcontrib><creatorcontrib>Gödiker, Juliana</creatorcontrib><creatorcontrib>Reinartz Groba, Sara Noemi</creatorcontrib><creatorcontrib>Kimmann, Markus</creatorcontrib><creatorcontrib>Luetkens, Julian A</creatorcontrib><creatorcontrib>Chang, Johannes</creatorcontrib><creatorcontrib>Sprinkart, Alois M</creatorcontrib><creatorcontrib>Praktiknjo, Michael</creatorcontrib><title>3D-Volumetric Shunt Measurement for Detection of High-Risk Esophageal Varices in Liver Cirrhosis</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Esophageal varices (EV) and variceal hemorrhages are major causes of mortality in liver cirrhosis patients. Detecting EVs early is crucial for effective management. Computed tomography (CT) scans, commonly performed for various liver-related indications, provide an opportunity for non-invasive EV assessment. However, previous CT studies focused on variceal diameter, neglecting the three-dimensional (3D) nature of varices and shunt vessels. This study aims to evaluate the potential of 3D volumetric shunt-vessel measurements from routine CT scans for detecting high-risk esophageal varices in portal hypertension.
3D volumetric measurements of esophageal varices were conducted using routine CT scans and compared to endoscopic variceal grading. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff value for identifying high-risk varices based on shunt volume. The study included 142 patients who underwent both esophagogastroduodenoscopy (EGD) and contrast-enhanced CT within six months.
The study established a cutoff value for identifying high-risk varices. The CT measurements exhibited a significant correlation with endoscopic EV grading (correlation coefficient r = 0.417,
< 0.001). A CT cutoff value of 2060 mm
for variceal volume showed a sensitivity of 72.1% and a specificity of 65.5% for detecting high-risk varices during endoscopy.
This study demonstrates the feasibility of opportunistically measuring variceal volumes from routine CT scans. CT volumetry for assessing EVs may have prognostic value, especially in cirrhosis patients who are not suitable candidates for endoscopy.</description><subject>Ascites</subject><subject>Chronic diseases</subject><subject>Chronic illnesses</subject><subject>Complications and side effects</subject><subject>CT imaging</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Disease prevention</subject><subject>Endoscopy</subject><subject>Esophageal varices</subject><subject>Esophagus</subject><subject>Gastroenterology</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Liver transplants</subject><subject>Measurement</subject><subject>Medical imaging</subject><subject>Risk factors</subject><subject>Tomography</subject><subject>Ultrasonic imaging</subject><subject>Varicose veins</subject><subject>Volumetric analysis</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkdFLHDEQxkOpVFGffC-BvhRkNdnZSzaPcqe1cCK06uuaTWbvct3dnMmu4H9vrl7LtTh5mI_w-2YGPkJOODsDUOx8ZToOTOVClh_IQc6kzBiU8HFH75PjGFcsVVkWOZefyD6UEnjOxAF5hFn24NuxwyE4Q38ux36gN6jjGLDDpBsf6AwHNIPzPfUNvXaLZfbDxV_0Mvr1Ui9Qt_RBJzdG6no6d88Y6NSFsPTRxSOy1-g24vG2H5L7q8u76XU2v_32fXoxzwxINWSlsGCZKurScsYKbfNac2VZbaXRpoZaScFtUTAQ2CjbCGZ1DryuQeRaJ3lIvr7NXQf_NGIcqs5Fg22re_RjrIBNQElZ5iKhX_5DV34MfbruN8ULwXaphW6xcn3jh6DNZmh1IRVMxCTtT9TZO1R6FjtnfI-NS___GE7fDCb4GAM21Tq4ToeXirNqE2m1E2miP29PHesO7V_2T4DwCgHAmXs</recordid><startdate>20240501</startdate><enddate>20240501</enddate><creator>Glückert, Kathleen</creator><creator>Decker, Alexandra</creator><creator>Meier, Jörn Arne</creator><creator>Nowak, Sebastian</creator><creator>Sanoubara, Feras</creator><creator>Gödiker, Juliana</creator><creator>Reinartz Groba, Sara Noemi</creator><creator>Kimmann, Markus</creator><creator>Luetkens, Julian A</creator><creator>Chang, Johannes</creator><creator>Sprinkart, Alois M</creator><creator>Praktiknjo, Michael</creator><general>MDPI AG</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1435-9562</orcidid><orcidid>https://orcid.org/0000-0001-7033-9956</orcidid><orcidid>https://orcid.org/0000-0002-7715-4636</orcidid></search><sort><creationdate>20240501</creationdate><title>3D-Volumetric Shunt Measurement for Detection of High-Risk Esophageal Varices in Liver Cirrhosis</title><author>Glückert, Kathleen ; Decker, Alexandra ; Meier, Jörn Arne ; Nowak, Sebastian ; Sanoubara, Feras ; Gödiker, Juliana ; Reinartz Groba, Sara Noemi ; Kimmann, Markus ; Luetkens, Julian A ; Chang, Johannes ; Sprinkart, Alois M ; Praktiknjo, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c379t-86d3d094b8d1004ad2ba19d0bd7cacb3b9761d44036ef9df60da231bb362aaa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ascites</topic><topic>Chronic diseases</topic><topic>Chronic illnesses</topic><topic>Complications and side effects</topic><topic>CT imaging</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Disease prevention</topic><topic>Endoscopy</topic><topic>Esophageal varices</topic><topic>Esophagus</topic><topic>Gastroenterology</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>Liver transplants</topic><topic>Measurement</topic><topic>Medical imaging</topic><topic>Risk factors</topic><topic>Tomography</topic><topic>Ultrasonic imaging</topic><topic>Varicose veins</topic><topic>Volumetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Glückert, Kathleen</creatorcontrib><creatorcontrib>Decker, Alexandra</creatorcontrib><creatorcontrib>Meier, Jörn Arne</creatorcontrib><creatorcontrib>Nowak, Sebastian</creatorcontrib><creatorcontrib>Sanoubara, Feras</creatorcontrib><creatorcontrib>Gödiker, Juliana</creatorcontrib><creatorcontrib>Reinartz Groba, Sara Noemi</creatorcontrib><creatorcontrib>Kimmann, Markus</creatorcontrib><creatorcontrib>Luetkens, Julian A</creatorcontrib><creatorcontrib>Chang, Johannes</creatorcontrib><creatorcontrib>Sprinkart, Alois M</creatorcontrib><creatorcontrib>Praktiknjo, Michael</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Glückert, Kathleen</au><au>Decker, Alexandra</au><au>Meier, Jörn Arne</au><au>Nowak, Sebastian</au><au>Sanoubara, Feras</au><au>Gödiker, Juliana</au><au>Reinartz Groba, Sara Noemi</au><au>Kimmann, Markus</au><au>Luetkens, Julian A</au><au>Chang, Johannes</au><au>Sprinkart, Alois M</au><au>Praktiknjo, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>3D-Volumetric Shunt Measurement for Detection of High-Risk Esophageal Varices in Liver Cirrhosis</atitle><jtitle>Journal of clinical medicine</jtitle><addtitle>J Clin Med</addtitle><date>2024-05-01</date><risdate>2024</risdate><volume>13</volume><issue>9</issue><spage>2678</spage><pages>2678-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Esophageal varices (EV) and variceal hemorrhages are major causes of mortality in liver cirrhosis patients. Detecting EVs early is crucial for effective management. Computed tomography (CT) scans, commonly performed for various liver-related indications, provide an opportunity for non-invasive EV assessment. However, previous CT studies focused on variceal diameter, neglecting the three-dimensional (3D) nature of varices and shunt vessels. This study aims to evaluate the potential of 3D volumetric shunt-vessel measurements from routine CT scans for detecting high-risk esophageal varices in portal hypertension.
3D volumetric measurements of esophageal varices were conducted using routine CT scans and compared to endoscopic variceal grading. Receiver operating characteristic (ROC) analyses were performed to determine the optimal cutoff value for identifying high-risk varices based on shunt volume. The study included 142 patients who underwent both esophagogastroduodenoscopy (EGD) and contrast-enhanced CT within six months.
The study established a cutoff value for identifying high-risk varices. The CT measurements exhibited a significant correlation with endoscopic EV grading (correlation coefficient r = 0.417,
< 0.001). A CT cutoff value of 2060 mm
for variceal volume showed a sensitivity of 72.1% and a specificity of 65.5% for detecting high-risk varices during endoscopy.
This study demonstrates the feasibility of opportunistically measuring variceal volumes from routine CT scans. CT volumetry for assessing EVs may have prognostic value, especially in cirrhosis patients who are not suitable candidates for endoscopy.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38731206</pmid><doi>10.3390/jcm13092678</doi><orcidid>https://orcid.org/0000-0002-1435-9562</orcidid><orcidid>https://orcid.org/0000-0001-7033-9956</orcidid><orcidid>https://orcid.org/0000-0002-7715-4636</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Ascites Chronic diseases Chronic illnesses Complications and side effects CT imaging Development and progression Diagnosis Disease prevention Endoscopy Esophageal varices Esophagus Gastroenterology Health aspects Hospitals Hypertension Liver cancer Liver cirrhosis Liver diseases Liver transplants Measurement Medical imaging Risk factors Tomography Ultrasonic imaging Varicose veins Volumetric analysis |
| title | 3D-Volumetric Shunt Measurement for Detection of High-Risk Esophageal Varices in Liver Cirrhosis |
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