Elucidating Gender-Specific Distribution of Imipramine, Chloroquine, and Their Metabolites in Mice Kidney Tissues through AP-MALDI-MSI

Knowledge of gender-specific drug distributions in different organs are of great importance for personalized medicine and reducing toxicity. However, such drug distributions have not been well studied. In this study, we investigated potential differences in the distribution of imipramine and chloroq...

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Veröffentlicht in:	International journal of molecular sciences 2024-05, Vol.25 (9), p.4840
Hauptverfasser:	Islam, Md Monirul, Rahman, Md Foyzur, Islam, Ariful, Afroz, Mst Sayela, Mamun, Md Al, Rahman, Md Muedur, Maniruzzaman, Md, Xu, Lili, Sakamoto, Takumi, Takahashi, Yutaka, Sato, Tomohito, Kahyo, Tomoaki, Setou, Mitsutoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioluminescence Body fat Chloroquine - metabolism Chloroquine - pharmacology Cytochrome Drugs Enzymes Female Females Gender Imipramine Imipramine - metabolism Ionization Kidney - metabolism Kidneys Male Males Mass spectrometry Metabolites Mice Pharmacokinetics Physiology Precision medicine Scientific imaging Sex Characteristics Sex Factors Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tissue Distribution Toxicity Womens health
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