Tigecycline Opposes Bortezomib Effect on Myeloma Cells Decreasing Mitochondrial Reactive Oxygen Species Production

Multiple myeloma is an incurable plasma cell malignancy. Most patients end up relapsing and developing resistance to antineoplastic drugs, like bortezomib. Antibiotic tigecycline has activity against myeloma. This study analyzed tigecycline and bortezomib combination on cell lines and plasma cells f...

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Veröffentlicht in:	International journal of molecular sciences 2024-05, Vol.25 (9), p.4887
Hauptverfasser:	Ramos-Acosta, Carlos, Huerta-Pantoja, Laura, Salazar-Hidalgo, Milton Eduardo, Mayol, Elsa, Jiménez-Vega, Selene, García-Peña, Pablo, Jordi-Cruz, Jenifeer, Baquero, Cristina, Porras, Almudena, Íñigo-Rodríguez, Belén, Benavente, Celina M, López-Pastor, Andrea R, Gómez-Delgado, Irene, Urcelay, Elena, Candel, Francisco Javier, Anguita, Eduardo
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents - pharmacology Antioxidants Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Bone marrow Bortezomib Bortezomib - pharmacology Cancer therapies Cell cycle Cell Cycle - drug effects Cell death Cell Line, Tumor Cytotoxicity Development and progression Drug resistance in microorganisms Drugs Electron transport Enzymes Homeostasis Humans Immunoglobulins Inhibitor drugs Medical prognosis Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Mitochondrial DNA Mitophagy - drug effects Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Multiple Myeloma - pathology Oxidative stress Pathogenesis Peroxides Physiological aspects Plasma Reactive oxygen species Reactive Oxygen Species - metabolism Respiration Scientific equipment and supplies industry Statistical significance Superoxide Targeted cancer therapy Tigecycline - pharmacology
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