The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis
There are conflicting findings about the relationships between depression, anxiety, and cognitive dysfunction in people with multiple sclerosis (MS), and a paucity of research has examined the cumulative influence on cognition of depression plus anxiety. This study aimed to determine whether elevate...
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| Veröffentlicht in: | Journal of neurology 2024-08, Vol.271 (8), p.4885-4896 |
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| creator | Freedman, David E. Oh, Jiwon Kiss, Alex Puopolo, Juliana Wishart, Margaret Meza, Cecilia Feinstein, Anthony |
| description | There are conflicting findings about the relationships between depression, anxiety, and cognitive dysfunction in people with multiple sclerosis (MS), and a paucity of research has examined the cumulative influence on cognition of depression plus anxiety. This study aimed to determine whether elevated symptoms of depression and anxiety alone or in combination are associated with worse cognition in people with MS. In this cross-sectional analysis, people with MS consecutively seen at a tertiary neuropsychiatry clinic completed the Hospital Anxiety and Depression Scale for symptoms of depression (HADS-D) and anxiety (HADS-A), and the Minimal Assessment of Cognitive Function in MS for cognitive indices. Accounting for covariates, regression models predicted cognitive indices from scores for HADS-D, HADS-A, and the interaction. Of 831 people with MS, 72% were female, mean age was 43.2 years, and median Expanded Disability Status Scale score was 2.0. Depressive symptoms were independently predictive of lower verbal fluency (Controlled Oral Word Association Test,
p
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| doi_str_mv | 10.1007/s00415-024-12409-x |
| format | Article |
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p
< 0.01), verbal learning (California Verbal Learning Test-II (CVLT-II) total learning,
p
= 0.02), verbal delayed recall (CVLT-II delayed recall,
p
< 0.01), and processing speed (Symbol Digit Modalities Test,
p
< 0.01; three-second Paced Auditory Serial Addition Test (PASAT),
p
= 0.05; two-second PASAT,
p
= 0.01). Anxiety in people with depression predicted decreased visuospatial function (Judgment of Line Orientation,
p
= 0.05), verbal learning (
p
< 0.01), verbal delayed recall (
p
< 0.01), visuospatial recall (Brief Visuospatial Memory Test-Revised,
p
= 0.02), and executive function (Delis-Kaplan Executive Function System,
p
< 0.01). Anxiety alone was not independently predictive of cognition. In conclusion, depression, especially with comorbid anxiety, is associated with cognitive dysfunction in people with MS.]]></description><identifier>ISSN: 0340-5354</identifier><identifier>ISSN: 1432-1459</identifier><identifier>EISSN: 1432-1459</identifier><identifier>DOI: 10.1007/s00415-024-12409-x</identifier><identifier>PMID: 38730098</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Anxiety ; Anxiety - etiology ; Cognition & reasoning ; Cognitive ability ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; Cross-Sectional Studies ; Depression - etiology ; Executive function ; Female ; Humans ; Learning ; Male ; Medicine ; Medicine & Public Health ; Mental depression ; Middle Aged ; Multiple sclerosis ; Multiple Sclerosis - complications ; Multiple Sclerosis - psychology ; Neurology ; Neuropsychological Tests ; Neuroradiology ; Neurosciences ; Orientation behavior ; Original Communication ; Regression analysis ; Spatial memory ; Verbal learning</subject><ispartof>Journal of neurology, 2024-08, Vol.271 (8), p.4885-4896</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-54345d7a1cd9b1dd0891ab5f007332d6b9f42f27757b6ff9209064a0da9409423</citedby><cites>FETCH-LOGICAL-c375t-54345d7a1cd9b1dd0891ab5f007332d6b9f42f27757b6ff9209064a0da9409423</cites><orcidid>0000-0003-4340-3232</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00415-024-12409-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00415-024-12409-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38730098$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freedman, David E.</creatorcontrib><creatorcontrib>Oh, Jiwon</creatorcontrib><creatorcontrib>Kiss, Alex</creatorcontrib><creatorcontrib>Puopolo, Juliana</creatorcontrib><creatorcontrib>Wishart, Margaret</creatorcontrib><creatorcontrib>Meza, Cecilia</creatorcontrib><creatorcontrib>Feinstein, Anthony</creatorcontrib><title>The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis</title><title>Journal of neurology</title><addtitle>J Neurol</addtitle><addtitle>J Neurol</addtitle><description><![CDATA[There are conflicting findings about the relationships between depression, anxiety, and cognitive dysfunction in people with multiple sclerosis (MS), and a paucity of research has examined the cumulative influence on cognition of depression plus anxiety. This study aimed to determine whether elevated symptoms of depression and anxiety alone or in combination are associated with worse cognition in people with MS. In this cross-sectional analysis, people with MS consecutively seen at a tertiary neuropsychiatry clinic completed the Hospital Anxiety and Depression Scale for symptoms of depression (HADS-D) and anxiety (HADS-A), and the Minimal Assessment of Cognitive Function in MS for cognitive indices. Accounting for covariates, regression models predicted cognitive indices from scores for HADS-D, HADS-A, and the interaction. Of 831 people with MS, 72% were female, mean age was 43.2 years, and median Expanded Disability Status Scale score was 2.0. Depressive symptoms were independently predictive of lower verbal fluency (Controlled Oral Word Association Test,
p
< 0.01), verbal learning (California Verbal Learning Test-II (CVLT-II) total learning,
p
= 0.02), verbal delayed recall (CVLT-II delayed recall,
p
< 0.01), and processing speed (Symbol Digit Modalities Test,
p
< 0.01; three-second Paced Auditory Serial Addition Test (PASAT),
p
= 0.05; two-second PASAT,
p
= 0.01). Anxiety in people with depression predicted decreased visuospatial function (Judgment of Line Orientation,
p
= 0.05), verbal learning (
p
< 0.01), verbal delayed recall (
p
< 0.01), visuospatial recall (Brief Visuospatial Memory Test-Revised,
p
= 0.02), and executive function (Delis-Kaplan Executive Function System,
p
< 0.01). Anxiety alone was not independently predictive of cognition. In conclusion, depression, especially with comorbid anxiety, is associated with cognitive dysfunction in people with MS.]]></description><subject>Adult</subject><subject>Anxiety</subject><subject>Anxiety - etiology</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Depression - etiology</subject><subject>Executive function</subject><subject>Female</subject><subject>Humans</subject><subject>Learning</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - complications</subject><subject>Multiple Sclerosis - psychology</subject><subject>Neurology</subject><subject>Neuropsychological Tests</subject><subject>Neuroradiology</subject><subject>Neurosciences</subject><subject>Orientation behavior</subject><subject>Original Communication</subject><subject>Regression analysis</subject><subject>Spatial memory</subject><subject>Verbal learning</subject><issn>0340-5354</issn><issn>1432-1459</issn><issn>1432-1459</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1PHSEUhklTU6-2f6CLhqSbbrCHr8vgrjH1IzHpRteEGUAx3JkRZtJ7_72MV23ShQsCJ-9zXji8CH2lcEIB1M8CIKgkwAShTIAm2w9oRQVnhAqpP6IVcAFEcikO0VEpDwDQVOETOuSN4gC6WaF8c-9x7EOafd95PATs_Jh9KXHose1dXdvopx2uZTfc9XFahNjj0Q9j8vhvnO7xZk5TXKrSJZ-HEssptrirp0KK75YWm6qTTbuqfUYHwabiv7zsx-j2_PfN2SW5_nNxdfbrmnRcyYlIwYV0ytLO6ZY6B42mtpWhTs45c-tWB8ECU0qqdh2CZqBhLSw4q-tfCMaP0Y-975iHx9mXyWxi6XxKtvfDXAwHybXiuqEV_f4f-jDMub53oTSj0Ci6UGxPPU-WfTBjjhubd4aCWRIx-0RMTcQ8J2K2tenbi_Xcbrx7a3mNoAJ8D5Qq9Xc-_7v7HdsnagyXXg</recordid><startdate>20240801</startdate><enddate>20240801</enddate><creator>Freedman, David E.</creator><creator>Oh, Jiwon</creator><creator>Kiss, Alex</creator><creator>Puopolo, Juliana</creator><creator>Wishart, Margaret</creator><creator>Meza, Cecilia</creator><creator>Feinstein, Anthony</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4340-3232</orcidid></search><sort><creationdate>20240801</creationdate><title>The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis</title><author>Freedman, David E. ; Oh, Jiwon ; Kiss, Alex ; Puopolo, Juliana ; Wishart, Margaret ; Meza, Cecilia ; Feinstein, Anthony</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-54345d7a1cd9b1dd0891ab5f007332d6b9f42f27757b6ff9209064a0da9409423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Anxiety</topic><topic>Anxiety - etiology</topic><topic>Cognition & reasoning</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Depression - etiology</topic><topic>Executive function</topic><topic>Female</topic><topic>Humans</topic><topic>Learning</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - complications</topic><topic>Multiple Sclerosis - psychology</topic><topic>Neurology</topic><topic>Neuropsychological Tests</topic><topic>Neuroradiology</topic><topic>Neurosciences</topic><topic>Orientation behavior</topic><topic>Original Communication</topic><topic>Regression analysis</topic><topic>Spatial memory</topic><topic>Verbal learning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freedman, David E.</creatorcontrib><creatorcontrib>Oh, Jiwon</creatorcontrib><creatorcontrib>Kiss, Alex</creatorcontrib><creatorcontrib>Puopolo, Juliana</creatorcontrib><creatorcontrib>Wishart, Margaret</creatorcontrib><creatorcontrib>Meza, Cecilia</creatorcontrib><creatorcontrib>Feinstein, Anthony</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freedman, David E.</au><au>Oh, Jiwon</au><au>Kiss, Alex</au><au>Puopolo, Juliana</au><au>Wishart, Margaret</au><au>Meza, Cecilia</au><au>Feinstein, Anthony</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis</atitle><jtitle>Journal of neurology</jtitle><stitle>J Neurol</stitle><addtitle>J Neurol</addtitle><date>2024-08-01</date><risdate>2024</risdate><volume>271</volume><issue>8</issue><spage>4885</spage><epage>4896</epage><pages>4885-4896</pages><issn>0340-5354</issn><issn>1432-1459</issn><eissn>1432-1459</eissn><abstract><![CDATA[There are conflicting findings about the relationships between depression, anxiety, and cognitive dysfunction in people with multiple sclerosis (MS), and a paucity of research has examined the cumulative influence on cognition of depression plus anxiety. This study aimed to determine whether elevated symptoms of depression and anxiety alone or in combination are associated with worse cognition in people with MS. In this cross-sectional analysis, people with MS consecutively seen at a tertiary neuropsychiatry clinic completed the Hospital Anxiety and Depression Scale for symptoms of depression (HADS-D) and anxiety (HADS-A), and the Minimal Assessment of Cognitive Function in MS for cognitive indices. Accounting for covariates, regression models predicted cognitive indices from scores for HADS-D, HADS-A, and the interaction. Of 831 people with MS, 72% were female, mean age was 43.2 years, and median Expanded Disability Status Scale score was 2.0. Depressive symptoms were independently predictive of lower verbal fluency (Controlled Oral Word Association Test,
p
< 0.01), verbal learning (California Verbal Learning Test-II (CVLT-II) total learning,
p
= 0.02), verbal delayed recall (CVLT-II delayed recall,
p
< 0.01), and processing speed (Symbol Digit Modalities Test,
p
< 0.01; three-second Paced Auditory Serial Addition Test (PASAT),
p
= 0.05; two-second PASAT,
p
= 0.01). Anxiety in people with depression predicted decreased visuospatial function (Judgment of Line Orientation,
p
= 0.05), verbal learning (
p
< 0.01), verbal delayed recall (
p
< 0.01), visuospatial recall (Brief Visuospatial Memory Test-Revised,
p
= 0.02), and executive function (Delis-Kaplan Executive Function System,
p
< 0.01). Anxiety alone was not independently predictive of cognition. In conclusion, depression, especially with comorbid anxiety, is associated with cognitive dysfunction in people with MS.]]></abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38730098</pmid><doi>10.1007/s00415-024-12409-x</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-4340-3232</orcidid></addata></record> |
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| subjects | Adult Anxiety Anxiety - etiology Cognition & reasoning Cognitive ability Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Cross-Sectional Studies Depression - etiology Executive function Female Humans Learning Male Medicine Medicine & Public Health Mental depression Middle Aged Multiple sclerosis Multiple Sclerosis - complications Multiple Sclerosis - psychology Neurology Neuropsychological Tests Neuroradiology Neurosciences Orientation behavior Original Communication Regression analysis Spatial memory Verbal learning |
| title | The influence of depression and anxiety on cognition in people with multiple sclerosis: a cross-sectional analysis |
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