Matrine induces cardiotoxicity by promoting ferroptosis through the Nrf2 antioxidant system in H9c2 cells

Matrine (MT) has shown promising efficacy in various cancers and chronic hepatitis; however, its clinical application is limited because of its side effects. Our previous studies have indicated that MT can induce severe hepatotoxicity and nephrotoxicity. The current study aimed to investigate its ca...

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Veröffentlicht in:	Toxicology letters 2024-06, Vol.397, p.11-22
Hauptverfasser:	Wang, Xi, Lin, Zixiong, Tang, Xinyi, Xie, Minjuan, Li, Ting, Zhou, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Antioxidants - pharmacology Cardiotoxicity Cell Line Ferroptosis Ferroptosis - drug effects Glutathione - metabolism GPX4 Lipid Peroxidation - drug effects Matrine Matrines Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology NF-E2-Related Factor 2 - metabolism Nrf2 Oxidative stress Oxidative Stress - drug effects Quinolizines - pharmacology Rats Reactive Oxygen Species - metabolism Signal Transduction - drug effects
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