Comparison of feline and human immunodeficiency virus reverse transcriptase enzymes through chemical screening and computational analysis

Feline immunodeficiency virus (FIV) is a common infection found in domesticated and wild cats worldwide. Despite the wealth of therapeutic understanding of the disease in humans, considerably less information exists regarding the treatment of the disease in felines. Current treatment relies on drugs...

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Veröffentlicht in:	Chemical biology & drug design 2024-05, Vol.103 (5), p.e14530-n/a
Hauptverfasser:	Thammajong, Phanicha, Aiebchun, Thitinan, Boonyarattanakalin, Kanokthip, Gleeson, Duangkamol, Pobsuk, Nattakarn, Hannongbua, Supa, Choowongkomon, Kiattawee, Gleeson, M. Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Alkynes - pharmacology Animals Benzoxazines - chemistry Benzoxazines - pharmacology biochemical screening Cats cheminformatics Cyclopropanes - chemistry Cyclopropanes - pharmacology FIV HIV Reverse Transcriptase - antagonists & inhibitors HIV Reverse Transcriptase - metabolism HIV-1 - drug effects HIV-1 - enzymology HIV‐1 RT Humans Immunodeficiency Virus, Feline - drug effects Molecular Docking Simulation Pyrimidines - chemistry Pyrimidines - pharmacology Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - pharmacology Structure-Activity Relationship synthesis
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