Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus
We studied the relationship between the HSPA5 gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the HSPA5 gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes rs55736103-T/T , rs12009-G/...
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| Veröffentlicht in: | Bulletin of experimental biology and medicine 2024-03, Vol.176 (5), p.599-602 |
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| container_title | Bulletin of experimental biology and medicine |
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| creator | Klyosova, E. Yu Azarova, Yu. E. Ilyina, E. A. Goryainova, N. V. Polonikov, A. V. |
| description | We studied the relationship between the
HSPA5
gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the
HSPA5
gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes
rs55736103-T/T
,
rs12009-G/G
, and
rs391957-T/C-T/T
are associated with increased risk of type 2 diabetes in females. A rare haplotype,
rs55736103C-rs12009A-rs391957T HSPA5
, associated with a reduced risk of type 2 diabetes in females was found. Associations between polymorphisms of the
HSPA5
gene encoding heat shock protein and the risk of type 2 diabetes mellitus were established for the first time. |
| doi_str_mv | 10.1007/s10517-024-06075-2 |
| format | Article |
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HSPA5
gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the
HSPA5
gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes
rs55736103-T/T
,
rs12009-G/G
, and
rs391957-T/C-T/T
are associated with increased risk of type 2 diabetes in females. A rare haplotype,
rs55736103C-rs12009A-rs391957T HSPA5
, associated with a reduced risk of type 2 diabetes in females was found. Associations between polymorphisms of the
HSPA5
gene encoding heat shock protein and the risk of type 2 diabetes mellitus were established for the first time.</description><identifier>ISSN: 0007-4888</identifier><identifier>EISSN: 1573-8221</identifier><identifier>DOI: 10.1007/s10517-024-06075-2</identifier><identifier>PMID: 38724812</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adult ; Aged ; Biomedical and Life Sciences ; Biomedicine ; Case-Control Studies ; Cell Biology ; Diabetes ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - genetics ; Endoplasmic reticulum ; Endoplasmic Reticulum Chaperone BiP ; Female ; Females ; Gene Frequency - genetics ; Gene polymorphism ; Genetic Predisposition to Disease - genetics ; Genotype ; Genotype & phenotype ; Genotyping ; GRP78 protein ; Haplotypes ; Haplotypes - genetics ; Heat shock proteins ; Heat-Shock Proteins - genetics ; Humans ; Internal Medicine ; Kinases ; Laboratory Medicine ; Male ; Middle Aged ; Pathology ; Polymorphism, Single Nucleotide - genetics ; Protein folding ; Risk Factors ; Single-nucleotide polymorphism</subject><ispartof>Bulletin of experimental biology and medicine, 2024-03, Vol.176 (5), p.599-602</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-16396a58d37d6813a6175fe955c1668d473c441508158927eee4522dd1a848d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10517-024-06075-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10517-024-06075-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38724812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Klyosova, E. Yu</creatorcontrib><creatorcontrib>Azarova, Yu. E.</creatorcontrib><creatorcontrib>Ilyina, E. A.</creatorcontrib><creatorcontrib>Goryainova, N. V.</creatorcontrib><creatorcontrib>Polonikov, A. V.</creatorcontrib><title>Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus</title><title>Bulletin of experimental biology and medicine</title><addtitle>Bull Exp Biol Med</addtitle><addtitle>Bull Exp Biol Med</addtitle><description>We studied the relationship between the
HSPA5
gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the
HSPA5
gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes
rs55736103-T/T
,
rs12009-G/G
, and
rs391957-T/C-T/T
are associated with increased risk of type 2 diabetes in females. A rare haplotype,
rs55736103C-rs12009A-rs391957T HSPA5
, associated with a reduced risk of type 2 diabetes in females was found. Associations between polymorphisms of the
HSPA5
gene encoding heat shock protein and the risk of type 2 diabetes mellitus were established for the first time.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Case-Control Studies</subject><subject>Cell Biology</subject><subject>Diabetes</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Endoplasmic reticulum</subject><subject>Endoplasmic Reticulum Chaperone BiP</subject><subject>Female</subject><subject>Females</subject><subject>Gene Frequency - genetics</subject><subject>Gene polymorphism</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genotype</subject><subject>Genotype & phenotype</subject><subject>Genotyping</subject><subject>GRP78 protein</subject><subject>Haplotypes</subject><subject>Haplotypes - genetics</subject><subject>Heat shock proteins</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Kinases</subject><subject>Laboratory Medicine</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pathology</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Protein folding</subject><subject>Risk Factors</subject><subject>Single-nucleotide polymorphism</subject><issn>0007-4888</issn><issn>1573-8221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1vEzEQhi1ERUPhD3BAlrhwWerxd45R-QhSKyJazpazO6Fus-vg2RXKv8chBaQeOI1G87zvjOZl7BWIdyCEOycQBlwjpG6EFc408gmbgXGq8VLCUzYTlWq09_6UPSe6O7TCwjN2qryT2oOcsfWCKLcpjikPfI3jT8SBr_J23-eyu03UE88bvsQ48uvb3N7zVckjpoEvr1cLw-PQ8a-J7g_QzX6HXPL3KVYfJH6F220aJ3rBTjZxS_jyoZ6xbx8_3Fwsm8svnz5fLC6bVkk7NmDV3EbjO-U660FFC85scG5MC9b6TjvVag1GeDB-Lh0iaiNl10H0uqrUGXt79N2V_GNCGkOfqK1HxAHzREEJo-YOvNAVffMIvctTGep1B8qKusbZSskj1ZZMVHATdiX1sewDiHBIIBwTCDWB8DuBIKvo9YP1tO6x-yv58_IKqCNAdTR8x_Jv939sfwFcHI3n</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Klyosova, E. Yu</creator><creator>Azarova, Yu. E.</creator><creator>Ilyina, E. A.</creator><creator>Goryainova, N. V.</creator><creator>Polonikov, A. V.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20240301</creationdate><title>Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus</title><author>Klyosova, E. Yu ; Azarova, Yu. E. ; Ilyina, E. A. ; Goryainova, N. V. ; Polonikov, A. V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-16396a58d37d6813a6175fe955c1668d473c441508158927eee4522dd1a848d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Case-Control Studies</topic><topic>Cell Biology</topic><topic>Diabetes</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Endoplasmic reticulum</topic><topic>Endoplasmic Reticulum Chaperone BiP</topic><topic>Female</topic><topic>Females</topic><topic>Gene Frequency - genetics</topic><topic>Gene polymorphism</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genotype</topic><topic>Genotype & phenotype</topic><topic>Genotyping</topic><topic>GRP78 protein</topic><topic>Haplotypes</topic><topic>Haplotypes - genetics</topic><topic>Heat shock proteins</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Kinases</topic><topic>Laboratory Medicine</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pathology</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Protein folding</topic><topic>Risk Factors</topic><topic>Single-nucleotide polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Klyosova, E. Yu</creatorcontrib><creatorcontrib>Azarova, Yu. E.</creatorcontrib><creatorcontrib>Ilyina, E. A.</creatorcontrib><creatorcontrib>Goryainova, N. V.</creatorcontrib><creatorcontrib>Polonikov, A. V.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Bulletin of experimental biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Klyosova, E. Yu</au><au>Azarova, Yu. E.</au><au>Ilyina, E. A.</au><au>Goryainova, N. V.</au><au>Polonikov, A. V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus</atitle><jtitle>Bulletin of experimental biology and medicine</jtitle><stitle>Bull Exp Biol Med</stitle><addtitle>Bull Exp Biol Med</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>176</volume><issue>5</issue><spage>599</spage><epage>602</epage><pages>599-602</pages><issn>0007-4888</issn><eissn>1573-8221</eissn><abstract>We studied the relationship between the
HSPA5
gene polymorphisms and the risk of type 2 diabetes mellitus. Genotyping of three SNPs of the
HSPA5
gene was performed in 1579 patients with type 2 diabetes mellitus and 1650 healthy individuals. It was found that the genotypes
rs55736103-T/T
,
rs12009-G/G
, and
rs391957-T/C-T/T
are associated with increased risk of type 2 diabetes in females. A rare haplotype,
rs55736103C-rs12009A-rs391957T HSPA5
, associated with a reduced risk of type 2 diabetes in females was found. Associations between polymorphisms of the
HSPA5
gene encoding heat shock protein and the risk of type 2 diabetes mellitus were established for the first time.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38724812</pmid><doi>10.1007/s10517-024-06075-2</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Aged Biomedical and Life Sciences Biomedicine Case-Control Studies Cell Biology Diabetes Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - genetics Endoplasmic reticulum Endoplasmic Reticulum Chaperone BiP Female Females Gene Frequency - genetics Gene polymorphism Genetic Predisposition to Disease - genetics Genotype Genotype & phenotype Genotyping GRP78 protein Haplotypes Haplotypes - genetics Heat shock proteins Heat-Shock Proteins - genetics Humans Internal Medicine Kinases Laboratory Medicine Male Middle Aged Pathology Polymorphism, Single Nucleotide - genetics Protein folding Risk Factors Single-nucleotide polymorphism |
| title | Association between Polymorphisms of Heat Shock Protein HSPA5 and Risk of Type 2 Diabetes Mellitus |
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