Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy
Vaccination against coronavirus disease-19 (COVID-19) is highly effective in preventing severe disease and mortality. Adenoviral vector and mRNA vaccines were effective against intensive care unit (ICU) admission, but the effectiveness of inactivated vaccine on ICU admission was unclear. We aimed to...
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| Veröffentlicht in: | Journal of infection in developing countries 2024-04, Vol.18 (4), p.513-519 |
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| creator | Yıldırım, Süleyman Kirakli, Cenk Özdemir, Yeliz Tosun, Selma Ermin, Sinem Polat, Gülru Yılmaz, Celalettin Bilaçeroğlu, Semra Salık, Bilge Kömürcüoğlu, Berna Ödemiş, İlker Köse, Şükran Uzun, Uğur Aydın, Gaye İlhan, Enver |
| description | Vaccination against coronavirus disease-19 (COVID-19) is highly effective in preventing severe disease and mortality. Adenoviral vector and mRNA vaccines were effective against intensive care unit (ICU) admission, but the effectiveness of inactivated vaccine on ICU admission was unclear. We aimed to evaluate the effect of vaccination status on ICU admission in hospitalized COVID-19 patients in a country with heterologous vaccination policy.
This is a retrospective multicenter study conducted in three hospitals in Izmir, Turkey between 1 January 2021 and 31 March 2022. Patients aged ≥ 18 years and hospitalized due to COVID-19 were included in the study. Patients who had never been vaccinated and patients who had been vaccinated with a single dose were considered unvaccinated. A logistic regression analysis was performed for evaluating risk factors for ICU admission.
A total of 2,110 patients were included in the final analysis. The median age was 66 years (IQR, 53-76 years) and 54% of the patients were vaccinated. During the study period, 407 patients (19.3%) were transferred to the ICU due to disease severity. Patients who were admitted to the ICU were older (median age 68 vs. 65 years, p < 0.001); and the number of unvaccinated individuals was higher among ICU patients (57% vs. 45%, p < 0.001). In multivariate regression analysis, being unvaccinated was found to be the most important independent risk factor for ICU admission with an OR of 2.06 (95% CI, 1.64-2.59).
Vaccination against COVID-19 is effective against ICU admission and hospital mortality. |
| doi_str_mv | 10.3855/jidc.18342 |
| format | Article |
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This is a retrospective multicenter study conducted in three hospitals in Izmir, Turkey between 1 January 2021 and 31 March 2022. Patients aged ≥ 18 years and hospitalized due to COVID-19 were included in the study. Patients who had never been vaccinated and patients who had been vaccinated with a single dose were considered unvaccinated. A logistic regression analysis was performed for evaluating risk factors for ICU admission.
A total of 2,110 patients were included in the final analysis. The median age was 66 years (IQR, 53-76 years) and 54% of the patients were vaccinated. During the study period, 407 patients (19.3%) were transferred to the ICU due to disease severity. Patients who were admitted to the ICU were older (median age 68 vs. 65 years, p < 0.001); and the number of unvaccinated individuals was higher among ICU patients (57% vs. 45%, p < 0.001). In multivariate regression analysis, being unvaccinated was found to be the most important independent risk factor for ICU admission with an OR of 2.06 (95% CI, 1.64-2.59).
Vaccination against COVID-19 is effective against ICU admission and hospital mortality.</description><identifier>ISSN: 1972-2680</identifier><identifier>ISSN: 2036-6590</identifier><identifier>EISSN: 1972-2680</identifier><identifier>DOI: 10.3855/jidc.18342</identifier><identifier>PMID: 38728641</identifier><language>eng</language><publisher>Italy: Journal of Infection in Developing Countries</publisher><subject>Aged ; Coronaviruses ; COVID-19 - prevention & control ; COVID-19 vaccines ; COVID-19 Vaccines - administration & dosage ; COVID-19 Vaccines - immunology ; Female ; Hospitalization ; Hospitalization - statistics & numerical data ; Humans ; Immunization ; Intensive Care Units ; Male ; Middle Aged ; Mortality ; Regression analysis ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 - immunology ; Turkey ; Vaccination - statistics & numerical data</subject><ispartof>Journal of infection in developing countries, 2024-04, Vol.18 (4), p.513-519</ispartof><rights>Copyright (c) 2024 Süleyman Yıldırım, Cenk Kirakli, Yeliz Özdemir, Selma Tosun, Sinem Ermin, Gülru Polat, Celalettin Yılmaz, Semra Bilaçeroğlu, Bilge Salık, Berna Kömürcüoğlu, İlker Ödemiş, Şükran Köse, Uğur Uzun, Gaye Aydın, Enver İlhan.</rights><rights>2024. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-0400-9403 ; 0000-0001-9844-9399 ; 0000-0002-9703-9598 ; 0000-0003-2638-0163 ; 0000-0001-9856-3431</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38728641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yıldırım, Süleyman</creatorcontrib><creatorcontrib>Kirakli, Cenk</creatorcontrib><creatorcontrib>Özdemir, Yeliz</creatorcontrib><creatorcontrib>Tosun, Selma</creatorcontrib><creatorcontrib>Ermin, Sinem</creatorcontrib><creatorcontrib>Polat, Gülru</creatorcontrib><creatorcontrib>Yılmaz, Celalettin</creatorcontrib><creatorcontrib>Bilaçeroğlu, Semra</creatorcontrib><creatorcontrib>Salık, Bilge</creatorcontrib><creatorcontrib>Kömürcüoğlu, Berna</creatorcontrib><creatorcontrib>Ödemiş, İlker</creatorcontrib><creatorcontrib>Köse, Şükran</creatorcontrib><creatorcontrib>Uzun, Uğur</creatorcontrib><creatorcontrib>Aydın, Gaye</creatorcontrib><creatorcontrib>İlhan, Enver</creatorcontrib><title>Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy</title><title>Journal of infection in developing countries</title><addtitle>J Infect Dev Ctries</addtitle><description>Vaccination against coronavirus disease-19 (COVID-19) is highly effective in preventing severe disease and mortality. Adenoviral vector and mRNA vaccines were effective against intensive care unit (ICU) admission, but the effectiveness of inactivated vaccine on ICU admission was unclear. We aimed to evaluate the effect of vaccination status on ICU admission in hospitalized COVID-19 patients in a country with heterologous vaccination policy.
This is a retrospective multicenter study conducted in three hospitals in Izmir, Turkey between 1 January 2021 and 31 March 2022. Patients aged ≥ 18 years and hospitalized due to COVID-19 were included in the study. Patients who had never been vaccinated and patients who had been vaccinated with a single dose were considered unvaccinated. A logistic regression analysis was performed for evaluating risk factors for ICU admission.
A total of 2,110 patients were included in the final analysis. The median age was 66 years (IQR, 53-76 years) and 54% of the patients were vaccinated. During the study period, 407 patients (19.3%) were transferred to the ICU due to disease severity. Patients who were admitted to the ICU were older (median age 68 vs. 65 years, p < 0.001); and the number of unvaccinated individuals was higher among ICU patients (57% vs. 45%, p < 0.001). In multivariate regression analysis, being unvaccinated was found to be the most important independent risk factor for ICU admission with an OR of 2.06 (95% CI, 1.64-2.59).
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Adenoviral vector and mRNA vaccines were effective against intensive care unit (ICU) admission, but the effectiveness of inactivated vaccine on ICU admission was unclear. We aimed to evaluate the effect of vaccination status on ICU admission in hospitalized COVID-19 patients in a country with heterologous vaccination policy.
This is a retrospective multicenter study conducted in three hospitals in Izmir, Turkey between 1 January 2021 and 31 March 2022. Patients aged ≥ 18 years and hospitalized due to COVID-19 were included in the study. Patients who had never been vaccinated and patients who had been vaccinated with a single dose were considered unvaccinated. A logistic regression analysis was performed for evaluating risk factors for ICU admission.
A total of 2,110 patients were included in the final analysis. The median age was 66 years (IQR, 53-76 years) and 54% of the patients were vaccinated. During the study period, 407 patients (19.3%) were transferred to the ICU due to disease severity. Patients who were admitted to the ICU were older (median age 68 vs. 65 years, p < 0.001); and the number of unvaccinated individuals was higher among ICU patients (57% vs. 45%, p < 0.001). In multivariate regression analysis, being unvaccinated was found to be the most important independent risk factor for ICU admission with an OR of 2.06 (95% CI, 1.64-2.59).
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| subjects | Aged Coronaviruses COVID-19 - prevention & control COVID-19 vaccines COVID-19 Vaccines - administration & dosage COVID-19 Vaccines - immunology Female Hospitalization Hospitalization - statistics & numerical data Humans Immunization Intensive Care Units Male Middle Aged Mortality Regression analysis Retrospective Studies Risk Factors SARS-CoV-2 - immunology Turkey Vaccination - statistics & numerical data |
| title | Impact of vaccination on ICU admissions of hospitalized COVID-19 patients in a country with a heterologous vaccine policy |
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