Synthesis of New Chroman‐4‐one Based 1,2,3‐Triazole Analogues as Antioxidant and Anti‐Inflammatory Agents

A library of new chroman‐4‐one based 1,2,3‐triazole analogues were synthesized involving a series of condensation, cyclization, Suzuki coupling and copper catalysed click chemistry protocols. The newly synthesized compounds 8a–l were screened for their invitro antioxidant and anti‐inflammatory activ...

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Veröffentlicht in:Chemistry & biodiversity 2024-07, Vol.21 (7), p.e202400587-n/a
Hauptverfasser: Ambala, Shankaraiah, Thumma, Vishnu, Mallikanti, Veerabhadraiah, Bathini, Vineesha, K, Jyothi, Pochampally, Jalapathi
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container_issue 7
container_start_page e202400587
container_title Chemistry & biodiversity
container_volume 21
creator Ambala, Shankaraiah
Thumma, Vishnu
Mallikanti, Veerabhadraiah
Bathini, Vineesha
K, Jyothi
Pochampally, Jalapathi
description A library of new chroman‐4‐one based 1,2,3‐triazole analogues were synthesized involving a series of condensation, cyclization, Suzuki coupling and copper catalysed click chemistry protocols. The newly synthesized compounds 8a–l were screened for their invitro antioxidant and anti‐inflammatory activities by employing Ascorbic acid and Diclofenac as reference drugs respectively. The compound without any substituent on benzyl ring (8a), compound with ‐Cl substituent in para position of benzyl ring (8i), and compound with ethoxy substituent in para position of benzyl ring (8k) exhibited potent antioxidant and anti‐inflammatory activities with higher percentage of inhibition. To understand their binding affinities, molecular docking study of these three compounds performed against NADPH oxidase with presented outstanding docking scores and promising binding interactions like H‐bond and hydrophobic.
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subjects anti-inflammatory
antioxidant
Antioxidants
Ascorbic acid
Binding
Chemical bonds
Chemical synthesis
Chroman-4-one
Diclofenac
Hydrophobicity
Inflammation
Molecular docking
NAD(P)H oxidase
NADPH oxidase
Triazoles
title Synthesis of New Chroman‐4‐one Based 1,2,3‐Triazole Analogues as Antioxidant and Anti‐Inflammatory Agents
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